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Journal of clinical medicine
Jan 18, 2024;13 (2):

Post-Irradiation Breast Angiosarcoma: All the Possible Treatments and Electrochemotherapy. Case Report and Literature Review.

Simona Parisi, Claudio Gambardella, Francesco Iovino, Roberto Ruggiero, Francesco Saverio Lucido, Giusiana Nesta, Salvatore Tolone, Luigi Brusciano, Francesca Fisone, Federico Maria Mongardini, Giovanni Cozzolino, Carminia Maria Della Corte, Stefania Napolitano, Michele Orditura, Rosetta Esposito, Ludovico Docimo
Author Information
  1. Simona Parisi: Department of Advanced Medical and Surgical Sciences, School of Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy. ORCID
  2. Claudio Gambardella: Department of Advanced Medical and Surgical Sciences, School of Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy. ORCID
  3. Francesco Iovino: Division of General, Oncological, Mini-Invasive and Obesity Surgery, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
  4. Roberto Ruggiero: Department of Advanced Medical and Surgical Sciences, School of Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
  5. Francesco Saverio Lucido: Department of Advanced Medical and Surgical Sciences, School of Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
  6. Giusiana Nesta: Division of General, Oncological, Mini-Invasive and Obesity Surgery, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
  7. Salvatore Tolone: Department of Advanced Medical and Surgical Sciences, School of Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
  8. Luigi Brusciano: Department of Advanced Medical and Surgical Sciences, School of Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
  9. Francesca Fisone: Division of General, Oncological, Mini-Invasive and Obesity Surgery, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy. ORCID
  10. Federico Maria Mongardini: Division of General, Oncological, Mini-Invasive and Obesity Surgery, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
  11. Giovanni Cozzolino: Division of General, Oncological, Mini-Invasive and Obesity Surgery, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
  12. Carminia Maria Della Corte: Medical Oncology, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via S. Pansini 5, 80131 Naples, Italy.
  13. Stefania Napolitano: Medical Oncology, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via S. Pansini 5, 80131 Naples, Italy.
  14. Michele Orditura: Medical Oncology, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via S. Pansini 5, 80131 Naples, Italy.
  15. Rosetta Esposito: Division of General, Oncological, Mini-Invasive and Obesity Surgery, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
  16. Ludovico Docimo: Department of Advanced Medical and Surgical Sciences, School of Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
PMID: 38256700 DOI: 10.3390/jcm13020567

Abstract

Breast angiosarcoma is a rare malignancy, accounting for less than 1% of all soft tissue cancers. It comprises primitive and secondary subtypes, such as radiogenic Breast angiosarcoma (RAS). Despite multimodal treatment, angiosarcomas represent an incurable disease for many patients and a significant cause of deterioration in their quality of life. Surgery is a cornerstone in management, but high recurrence rates are reported. Electrochemotherapy (ECT) is a practicable locoregional treatment for patients with advanced angiosarcoma as part of a multimodal therapeutic strategy. The palliative benefits of ECT include optimal patient compliance, good local hemostasis control, and positive local responses. Since only 22 cases are described in the literature, we reported a rare case of RAS treated with ECT after a multidisciplinary approach, including Next Generation Sequencing (NGS). A literature review on the feasibility of ECT in RAS management was also performed.

Keywords

breast angiosarcoma electrochemotherapy post-irradiation angiosarcoma

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Journal Article Review

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