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Antibiotics (Basel, Switzerland)
Dec 20, 2023;13 (1):

Antibiofilm and Antivirulence Properties of 6-Polyaminosteroid Derivatives against Antibiotic-Resistant Bacteria.

Delphine Vergoz, Hung Le, Benoit Bernay, Annick Schaumann, Magalie Barreau, Flore Nilly, Florie Desriac, Ali Tahrioui, Jean-Christophe Giard, Olivier Lesouhaitier, Sylvie Chevalier, Jean Michel Brunel, C��cile Muller, Emmanuelle D��
Author Information
  1. Delphine Vergoz: Univ Rouen Normandie, INSA Rouen Normandie, CNRS, Normandie Univ, PBS UMR 6270, F-76000 Rouen, France. ORCID
  2. Hung Le: Univ Rouen Normandie, INSA Rouen Normandie, CNRS, Normandie Univ, PBS UMR 6270, F-76000 Rouen, France. ORCID
  3. Benoit Bernay: Univ Caen Normandie, Proteogen Platform, US EMERODE, F-14000 Caen, France.
  4. Annick Schaumann: Univ Rouen Normandie, INSA Rouen Normandie, CNRS, Normandie Univ, PBS UMR 6270, F-76000 Rouen, France.
  5. Magalie Barreau: Univ Rouen Normandie, Univ Caen Normandie, Normandie Univ, Communication Bact��rienne et Strat��gies Anti-Infectieuses, CBSA UR4312, F-76000 Rouen, France.
  6. Flore Nilly: Univ Rouen Normandie, Univ Caen Normandie, Normandie Univ, Communication Bact��rienne et Strat��gies Anti-Infectieuses, CBSA UR4312, F-76000 Rouen, France.
  7. Florie Desriac: Univ Rouen Normandie, Univ Caen Normandie, Normandie Univ, Communication Bact��rienne et Strat��gies Anti-Infectieuses, CBSA UR4312, F-76000 Rouen, France.
  8. Ali Tahrioui: Univ Rouen Normandie, Univ Caen Normandie, Normandie Univ, Communication Bact��rienne et Strat��gies Anti-Infectieuses, CBSA UR4312, F-76000 Rouen, France. ORCID
  9. Jean-Christophe Giard: UNICAEN, Univ Rouen Normandie, INSERM, DYNAMICURE UMR 1311, F-14000 Caen, France.
  10. Olivier Lesouhaitier: Univ Rouen Normandie, Univ Caen Normandie, Normandie Univ, Communication Bact��rienne et Strat��gies Anti-Infectieuses, CBSA UR4312, F-76000 Rouen, France. ORCID
  11. Sylvie Chevalier: Univ Rouen Normandie, Univ Caen Normandie, Normandie Univ, Communication Bact��rienne et Strat��gies Anti-Infectieuses, CBSA UR4312, F-76000 Rouen, France. ORCID
  12. Jean Michel Brunel: Aix Marseille Univ, INSERM, SSA, MCT, F-13385 Marseille, France. ORCID
  13. C��cile Muller: Univ Rouen Normandie, Univ Caen Normandie, Normandie Univ, Communication Bact��rienne et Strat��gies Anti-Infectieuses, CBSA UR4312, F-76000 Rouen, France. ORCID
  14. Emmanuelle D��: Univ Rouen Normandie, INSA Rouen Normandie, CNRS, Normandie Univ, PBS UMR 6270, F-76000 Rouen, France. ORCID
PMID: 38275318 DOI: 10.3390/antibiotics13010008

Abstract

The emergence of multi-drug resistant pathogens is a major public health problem, leading us to rethink and innovate our bacterial control strategies. Here, we explore the antibiofilm and antivirulence activities of nineteen 6-polyaminosterol derivatives (squalamine-based), presenting a modulation of their polyamine side chain on four major pathogens, i.e., carbapenem-resistant (CRAB) and (CRPA), methicillin-resistant (MRSA), and vancomycin-resistant (VRE) strains. We screened the effect of these derivatives on biofilm formation and eradication. Derivatives (for CRAB, VRE, and MRSA) and (for all the strains) were the most potent ones and displayed activities as good as those of conventional antibiotics. We also identified 11 compounds able to decrease by more than 40% the production of pyocyanin, a major virulence factor of . We demonstrated that treatment acts against bacterial infections in and significantly prolonged larvae survival (from 50% to 80%) after 24 h of CRAB, VRE, and MRSA infections. As shown by proteomic studies, triggered distinct cellular responses depending on the bacterial species but essentially linked to cell envelope. Its interesting antibiofilm and antivirulence properties make it a promising a candidate for use in therapeutics.

Keywords

6-aminosteroid derivatives antibiofilm antivirulence pyocyanin

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Grants

  1. RN-3A/R��gion Normandie
Journal Article
Article has an altmetric score of 1

Word Cloud

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