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Nutrients
Jan 19, 2024;16 (2):

The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer's and Parkinson's Diseases.

Witold Czarnik, Piotr Fularski, Agata Gajewska, Paulina Jakubowska, Zofia Uszok, Ewelina Młynarska, Jacek Rysz, Beata Franczyk
Author Information
  1. Witold Czarnik: Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland. ORCID
  2. Piotr Fularski: Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland. ORCID
  3. Agata Gajewska: Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland. ORCID
  4. Paulina Jakubowska: Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland. ORCID
  5. Zofia Uszok: Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland. ORCID
  6. Ewelina Młynarska: Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland. ORCID
  7. Jacek Rysz: Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland.
  8. Beata Franczyk: Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland.
PMID: 38276546 DOI: 10.3390/nu16020308

Abstract

Many researchers propose manipulating microbiota to prevent and treat related diseases. The brain-gut axis is an object that remains the target of modern research, and it is not without reason that many researchers enrich it with microbiota and diet in its name. Numerous connections and mutual correlations have become the basis for seeking answers to many questions related to pathology as well as human physiology. Disorders of this homeostasis as well as dysbiosis itself accompany neurodegenerative diseases such as Alzheimer's and Parkinson's. Heavily dependent on external factors, modulation of the gut microbiome represents an opportunity to advance the treatment of neurodegenerative diseases. Probiotic interventions, synbiotic interventions, or fecal transplantation can undoubtedly support the biotherapeutic process. A special role is played by diet, which provides metabolites that directly affect the body and the microbiota. A holistic view of the human organism is therefore essential.

Keywords

gut-brain axis microbiota neurodegenerative diseases

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MeSH Term

Humans
Gastrointestinal Microbiome
Parkinson Disease
Alzheimer Disease
Diet
Microbiota
Dysbiosis
Brain
Journal Article Review
Article has an altmetric score of 24

Word Cloud

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