BACKGROUND AND AIMS: To evaluate the prognostic significance of preoperative creatine kinase (CK) levels in bladder cancer (BCa) patients who underwent radical cystectomy (RC). MATERIALS AND METHODS: 570 BCa patients with RC were identified between 2010 and 2020. 108.5 U/L of CK levels were defined as the cutoff value. Logistic regression analysis and Cox regression models were performed to evaluate the association between CK levels and oncologic outcomes. Subgroup analyses were performed to address cofounding factors. RESULTS: Preoperative low CK levels were associated with worse recurrence-free survival (RFS, log-rank P = 0.001) and overall survival (OS, log-rank P = 0.002). Multivariate analysis revealed that preoperative low CK levels were an independent predictor for worse RFS (hazard ratio [HR]: 1.683; P < 0.001) and OS (HR: 1.567; P = 0.002). CONCLUSIONS: The preoperative low CK level independently predicts worse survival outcomes in BCa after RC. Incorporating it into prediction models might be valuable to assist risk stratification.
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Grants
82070784/National Natural Science Foundation of China
81702536/National Natural Science Foundation of China
81974099/National Natural Science Foundation of China
82170785/National Natural Science Foundation of China
2022JDRC0040/Science & Technology Department of Sichuan Province, China
21GJHZ0246/Science and Technology Department of Sichuan Province
2017SCU04A17/Young Investigator Award of Sichuan University 2017
2020CDPZH-4/Sichuan University--Panzhihua science and technology cooperation special fund
2021M692306/China Postdoctoral Science Foundation
2021HXBH025/Post-Doctor Research Project of West China Hospital of Sichuan University