The Management of Gonorrhea in the Era of Emerging Antimicrobial Resistance: What Primary Care Clinicians Should Know.

Laura A S Quilter, Sancta B St Cyr, Lindley A Barbee
Author Information
  1. Laura A S Quilter: Division of STD Prevention, Centers of Disease Control and Prevention, 1600 Clifton Road Northeast, MS H24-4, Atlanta, GA 30329, USA. Electronic address: lquilter@cdc.gov.
  2. Sancta B St Cyr: Division of STD Prevention, Centers of Disease Control and Prevention, 1600 Clifton Road Northeast, MS H24-4, Atlanta, GA 30329, USA.
  3. Lindley A Barbee: Division of STD Prevention, Centers of Disease Control and Prevention, 1600 Clifton Road Northeast, MS H24-4, Atlanta, GA 30329, USA.

Abstract

Gonorrhea rates continue to rise in the United States and Neisseria gonorrhoeae's propensity to develop resistance to all therapies used for treatment has complicated the management of gonorrhea. Ceftriaxone is the only remaining highly effective recommended regimen for gonococcal treatment and few new anti-gonococcal antimicrobials are being developed. The 2021 CDC STI Treatment Guidelines increased the dose of ceftriaxone to 500 mg (1 g if ≥ 150 kg) for uncomplicated infections. It is recommended that all clinicians should be aware of antimicrobial resistant gonorrhea and be able to appropriately manage any suspected gonorrhea treatment failure case.

Keywords

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Grants

  1. CC999999/Intramural CDC HHS

MeSH Term

Humans
United States
Gonorrhea
Anti-Bacterial Agents
Ceftriaxone
Neisseria gonorrhoeae
Drug Resistance, Bacterial
Anti-Infective Agents
Primary Health Care
Microbial Sensitivity Tests

Chemicals

Anti-Bacterial Agents
Ceftriaxone
Anti-Infective Agents

Word Cloud

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