Radiation-induced glymphatic dysfunction in patients with nasopharyngeal carcinoma: a study using diffusion tensor image analysis along the perivascular space.
Xingyou Zheng, Jianchun Peng, Qing Zhao, Li Li, Jian-Ming Gao, Keyang Zhou, Bei Tan, Lingling Deng, Youming Zhang
Author Information
Xingyou Zheng: Department of Medical Imaging, The Fourth Hospital of Changsha, Changsha, Hunan, China.
Jianchun Peng: Department of Radiology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Qing Zhao: Department of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Li Li: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Jian-Ming Gao: Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Keyang Zhou: Department of Radiology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Bei Tan: Department of Radiology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Lingling Deng: Department of Radiology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Youming Zhang: Department of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Radiation encephalopathy (RE) refers to radiation-induced brain necrosis and is a life-threatening complication in patients with nasopharyngeal carcinoma (NPC) after radiotherapy (RT), and radiation-induced pre-symptomatic glymphatic alterations have not yet been investigated. We used diffusion tensor image analysis along the perivascular space (DTI-ALPS) index to examine the pre-symptomatic glymphatic alterations in NPC patients following RT. A total of 109 patients with NPC consisted of Pre-RT ( = 35) and Post-RT ( = 74) cohorts were included. The post-RT NPC patients, with normal-appearing brain structure at the time of MRI, were further divided into Post-RT-RE- ( = 58) and Post-RT-RE+ ( = 16) subgroups based on the detection of RE in follow-up. We observed lower DTI-ALPS index, DTI-ALPS index and DTI-ALPS index in post-RT patients than that in pre-RT patients ( < 0.05). We further found that post-RT-RE+ patients demonstrated significantly lower DTI-ALPS ( = 0.013), DTI-ALPS ( = 0.011) and marginally lower DTI-ALPS ( = 0.07) than Post-RT patients. Significant negative correlations were observed between the maximum dosage of radiation-treatment (MDRT) and DTI-ALPS index ( = 0.003) as well as DTI-ALPS index ( = 0.004). Receiver operating characteristic (ROC) curve analysis showed that DTI-ALPS index exhibited good performance (AUC = 0.706) in identifying patients more likely developing RE. We concluded that glympathic function was impaired in NPC patients following RT and DTI-ALPS index may serve as a novel imaging biomarker for diagnosis of RE.
