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Feb 09, 2024;

Sub-second and multi-second dopamine dynamics underlie variability in human time perception.

Renata Sadibolova, Emily K DiMarco, Angela Jiang, Benjamin Maas, Stephen B Tatter, Adrian Laxton, Kenneth T Kishida, Devin B Terhune
Author Information
  1. Renata Sadibolova: Department of Psychology, Goldsmiths, University of London; London SE14 6NW, UK. ORCID
  2. Emily K DiMarco: Neuroscience Graduate Program, Wake Forest School of Medicine; Winston-Salem, NC, 27157, USA. ORCID
  3. Angela Jiang: Department of Translational Neuroscience, Wake Forest School of Medicine; Winston-Salem, NC, 27157, USA. ORCID
  4. Benjamin Maas: Department of Translational Neuroscience, Wake Forest School of Medicine; Winston-Salem, NC, 27157, USA.
  5. Stephen B Tatter: Department of Neurosurgery, Wake Forest School of Medicine; Winston-Salem, NC, 27157, USA.
  6. Adrian Laxton: Department of Neurosurgery, Wake Forest School of Medicine; Winston-Salem, NC, 27157, USA.
  7. Kenneth T Kishida: Neuroscience Graduate Program, Wake Forest School of Medicine; Winston-Salem, NC, 27157, USA. ORCID
  8. Devin B Terhune: Department of Psychology, Goldsmiths, University of London; London SE14 6NW, UK. ORCID
PMID: 38370629 DOI: 10.1101/2024.02.09.24302276

Abstract

Timing behaviour and the perception of time are fundamental to cognitive and emotional processes in humans. In non-human model organisms, the neuromodulator dopamine has been associated with variations in timing behaviour, but the connection between variations in dopamine levels and the human experience of time has not been directly assessed. Here, we report how dopamine levels in human striatum, measured with sub-second temporal resolution during awake deep brain stimulation surgery, relate to participants' perceptual judgements of time intervals. Fast, phasic, dopaminergic signals were associated with underestimation of temporal intervals, whereas slower, tonic, decreases in dopamine were associated with poorer temporal precision. Our findings suggest a delicate and complex role for the dynamics and tone of dopaminergic signals in the conscious experience of time in humans.

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Grants

  1. R01 MH124115/NIMH NIH HHS
  2. R01 MH121099/NIMH NIH HHS
  3. UL1 TR001420/NCATS NIH HHS
  4. P50 DA006634/NIDA NIH HHS
  5. R01 DA048096/NIDA NIH HHS
Preprint Journal Article
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