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Brain imaging and behavior
Aug, 2024;18 (4): 710-719.

Structural and functional changes following brain surgery in pediatric patients with intracranial space-occupying lesions.

Xueyi Guan, Wenjian Zheng, Kaiyu Fan, Xu Han, Bohan Hu, Xiang Li, Zihan Yan, Zheng Lu, Jian Gong
Author Information
  1. Xueyi Guan: Department of Pediatric Neurosurgery Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. ORCID
  2. Wenjian Zheng: Department of Pediatric Neurosurgery Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  3. Kaiyu Fan: Department of Pediatric Neurosurgery Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  4. Xu Han: Department of Pediatric Neurosurgery Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  5. Bohan Hu: Department of Pediatric Neurosurgery Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  6. Xiang Li: Department of Pediatric Neurosurgery Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  7. Zihan Yan: Department of Pediatric Neurosurgery Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  8. Zheng Lu: Department of Pediatric Neurosurgery Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  9. Jian Gong: Department of Pediatric Neurosurgery Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. gongjian88@tom.com. ORCID
PMID: 38376714 DOI: 10.1007/s11682-023-00799-x

Abstract

We explored the structural and functional changes of the healthy hemisphere of the brain after surgery in children with intracranial space-occupying lesions. We enrolled 32 patients with unilateral intracranial space-occupying lesions for brain imaging and cognitive assessment. Voxel-based morphometry and surface-based morphometry analyses were used to investigate the structural images of the healthy hemisphere. Functional images were analyzed using regional homogeneity, amplitude of low-frequency fluctuations, and fractional-amplitude of low-frequency fluctuations. Voxel-based morphometry and surface-based morphometry analysis used the statistical model built into the CAT 12 toolbox. Paired t-tests were used for functional image and cognitive test scores. For structural image analysis, we used family-wise error correction of peak level (p < 0.05), and for functional image analysis, we use Gaussian random-field theory correction (voxel p < 0.001, cluster p < 0.05). We found an increase in gray matter volume in the healthy hemisphere within six months postoperatively, mainly in the frontal lobe. Regional homogeneity and fractional-amplitude of low-frequency fluctuations also showed greater functional activity in the frontal lobe. The results of cognitive tests showed that psychomotor speed and motor speed decreased significantly after surgery, and reasoning increased significantly after surgery. We concluded that in children with intracranial space-occupying lesions, the healthy hemisphere exhibits compensatory structural and functional effects within six months after surgery. This effect occurs mainly in the frontal lobe and is responsible for some higher cognitive compensation. This may provide some guidance for the rehabilitation of children after brain surgery.

Keywords

Brain imaging Brain tumors Cognitive assessment Frontal lobe Intracranial space-occupying lesions

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Grants

  1. 81870834/National Natural Science Foundation of China
  2. XTYB201817/Special project of peadiatrics of collaborative development centre of Beijing hospital administration

MeSH Term

Humans
Male
Child
Female
Magnetic Resonance Imaging
Brain
Adolescent
Gray Matter
Neuropsychological Tests
Brain Neoplasms
Neurosurgical Procedures
Brain Mapping
Cognition
Image Processing, Computer-Assisted
Child, Preschool
Journal Article

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