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Journal of microbiology and biotechnology
Apr 28, 2024;34 (4): 911-919.

1-Kestose Blocks UVB-Induced Skin Inflammation and Promotes Type I Procollagen Synthesis via Regulating MAPK/AP-1, NF-��B and TGF-��/Smad Pathway.

Jihye Baek, Jong-Hwa Kim, Jiwon Park, Do Hyun Kim, Soonok Sa, Jung-Sook Han, Wonyong Kim
Author Information
  1. Jihye Baek: Department of Microbiology, Chung-Ang University College of Medicine, Seoul 06974, Republic of Korea.
  2. Jong-Hwa Kim: Department of Microbiology, Chung-Ang University College of Medicine, Seoul 06974, Republic of Korea.
  3. Jiwon Park: Food R&D Center, Samyang Corp., Seongnam 13488, Republic of Korea.
  4. Do Hyun Kim: Food R&D Center, Samyang Corp., Seongnam 13488, Republic of Korea.
  5. Soonok Sa: Food R&D Center, Samyang Corp., Seongnam 13488, Republic of Korea.
  6. Jung-Sook Han: Food R&D Center, Samyang Corp., Seongnam 13488, Republic of Korea.
  7. Wonyong Kim: Department of Microbiology, Chung-Ang University College of Medicine, Seoul 06974, Republic of Korea.
PMID: 38379292 DOI: 10.4014/jmb.2311.11020

Abstract

Solar UVB irradiation cause skin photoaging by inducing the high expression of matrix metalloproteinase (MMPs) to inhibit the expression of Type1 procollagen synthesis. 1-kestose, a natural trisaccharide, has been indicated to show a cytoprotective role in UVB radiation-induced-HaCaT cells. However, few studies have confirmed the anti-aging effects. In the present study, we evaluated the anti-photoaging and pathological mechanism of 1-kestose using Human keratinocytes (HaCaT) cells. The results found that 1-kestose pretreatment remarkably reduced UVB-generated reactive oxygen species (ROS) accumulation in HaCaT cells. 1-kestose suppressed UVB radiation-induced MMPs expressions by blocking MAPK/AP-1 and NF-��B p65 translocation. 1-kestose pretreatment increased Type 1 procollagen gene expression levels by activating TGF-��/Smad signaling pathway. Taken together, our results demonstrate that 1-kestose may serve as a potent natural trisaccharide for inflammation and photoaging prevention.

Keywords

1-Kestose HaCaT cells MAPK/AP-1 NF-��B TGF-��/Smad UVB anti-inflammatory anti-photoaging

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MeSH Term

Humans
Collagen Type I
HaCaT Cells
Inflammation
Keratinocytes
Matrix Metalloproteinases
NF-kappa B
Reactive Oxygen Species
Signal Transduction
Skin
Skin Aging
Smad Proteins
Transcription Factor AP-1
Transforming Growth Factor beta
Ultraviolet Rays
Trisaccharides

Chemicals

Collagen Type I
Matrix Metalloproteinases
NF-kappa B
Reactive Oxygen Species
Smad Proteins
Transcription Factor AP-1
Transforming Growth Factor beta
1-kestose
Trisaccharides
Journal Article

Word Cloud

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