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02 23, 2024;14 (1): 4477.

Correlation between soluble klotho and chronic kidney disease-mineral and bone disorder in chronic kidney disease: a meta-analysis.

Zhongyu Fan, Xuejiao Wei, Xiaoyu Zhu, Kun Yang, Ling Tian, Yujun Du, Liming Yang
Author Information
  1. Zhongyu Fan: Department of Nephrology, The First Hospital of Jilin University, Changchun, China.
  2. Xuejiao Wei: Department of Nephrology, The First Hospital of Jilin University, Changchun, China.
  3. Xiaoyu Zhu: Department of Nephrology, The First Hospital of Jilin University, Changchun, China.
  4. Kun Yang: Department of Nephrology, The First Hospital of Jilin University, Changchun, China.
  5. Ling Tian: Department of Nephrology, The First Hospital of Jilin University, Changchun, China.
  6. Yujun Du: Department of Nephrology, The First Hospital of Jilin University, Changchun, China. duyj@jlu.edu.cn.
  7. Liming Yang: Department of Nephrology, The First Hospital of Jilin University, Changchun, China. yliming0815@163.com.
PMID: 38396063 DOI: 10.1038/s41598-024-54812-4

Abstract

We conducted a systematic search across medical databases, including PubMed, Web of Science, EMBASE, and Cochrane Library, up to March 2023. A total of 1944 subjects or individuals from 17 studies were included in our final analysis. The correlation coefficient (r) between sKlotho and calcium was [0.14, (0.02, 0.26)], and a moderate heterogeneity was observed (I = 66%, P < 0.05). The correlation coefficient (r) between Klotho and serum phosphate was [- 0.21, (- 0.37, - 0.04)], with apparent heterogeneity (I = 84%, P < 0.05). The correlation coefficient (r) between sKlotho and parathyroid hormone and vascular calcification was [- 0.23,(- 0.29, - 0.17); - 0.15, (- 0.23, - 0.08)], with no significant heterogeneity among the studies. (I = 40%, P < 0.05; I = 30%, P < 0.05). A significant correlation exists between low sKlotho levels and an increased risk of CKD-MBD in patients with CKD. According to the findings, sKlotho may play a role in alleviating CKD-MBD by lowering phosphorus and parathyroid hormone levels, regulating calcium levels, and suppressing vascular calcification. As analysis showed that sKlotho has an important impact on the pathogenesis and progression of CKD-MBD in CKD patients. Nonetheless, further comprehensive and high-quality studies are needed to validate our conclusions.

Keywords

Chronic kidney disease Chronic kidney disease–mineral and bone disorder Mineral metabolism Soluble Klotho Vascular calcification

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MeSH Term

Humans
Calcium
Chronic Kidney Disease-Mineral and Bone Disorder
Parathyroid Hormone
Renal Insufficiency, Chronic
Vascular Calcification

Chemicals

Calcium
Parathyroid Hormone
KL protein, human
Meta-Analysis Journal Article

Word Cloud

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