The effect of biopolymer gel derived from sugarcane on healing of traumatic oral ulcers: an experimental study.
Lívia Mirelle Barbosa, Lívia Maria Lopes de Oliveira, Camylla Pinheiro Verissimo Queiroz, Bruna Andrade Santos Freitas, Tarciana Maria Pereira de Lima, José Lamartine de Andrade Aguiar, Martinho Dinoá Medeiros Júnior, Danyel Elias da Cruz Perez, Gustavo Pina Godoy
Author Information
Lívia Mirelle Barbosa: Universidade Federal de Pernambuco - Recife (PE) - Brazil. ORCID
Lívia Maria Lopes de Oliveira: Universidade Federal de Pernambuco - Recife (PE) - Brazil. ORCID
Camylla Pinheiro Verissimo Queiroz: Universidade Federal de Pernambuco - Recife (PE) - Brazil. ORCID
Bruna Andrade Santos Freitas: Universidade Federal de Pernambuco - Recife (PE) - Brazil. ORCID
Tarciana Maria Pereira de Lima: Universidade Federal de Pernambuco - Recife (PE) - Brazil. ORCID
José Lamartine de Andrade Aguiar: Universidade Federal de Pernambuco - Recife (PE) - Brazil. ORCID
Martinho Dinoá Medeiros Júnior: Universidade Federal de Pernambuco - Recife (PE) - Brazil. ORCID
Danyel Elias da Cruz Perez: Universidade Federal de Pernambuco - Recife (PE) - Brazil. ORCID
Gustavo Pina Godoy: Universidade Federal de Pernambuco - Recife (PE) - Brazil. ORCID
PURPOSE: The extracellular polysaccharide (EPS) is produced by the bacterium Zoogloea sp. and plays a positive role in tissue repair. The purpose of this study was to clinically and histologically compare the effects of EPS in the healing of traumatic oral ulcers in rats with the effects of triamcinolone. METHODS: Ulcers were induced in the oral mucous of 45 male Wistar rats, divided into three groups: control group, treated with triamcinolone, and treated with biopolymer gel. In the clinical evaluation, we considered the weight variation of the animals and the size of the lesion area, at baseline and on treatment days 1, 3 and 7. The histological parameters evaluated were the type and intensity of the inflammatory infiltration, the presence of necrosis and foreign body granuloma and the degree of re-epithelialization of the lesion. RESULTS: The reduction of the lesion area was greater in the animals treated with EPS, with no difference in the intensity of the inflammatory infiltration between the groups on days 3 and 7 of treatment. CONCLUSIONS: The results suggest that topical application of EPS in traumatic oral ulcers of rats promotes faster repair than triamcinolone ointment, without increasing the intensity of inflammatory infiltration under the lesion.
