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08, 2024;397 (8): 5559-5569.

Immobilised antimicrobial peptides in downregulation of biofilm.

Moupriya Nag, Debasmita Bhattacharya, Sayantani Garai, Bandita Dutta, Sreejita Ghosh, Rina Rani Ray, Dibyajit Lahiri
Author Information
  1. Moupriya Nag: Department of Biotechnology, Institute of Engineering and Management, Kolkata, New Town, University of Engineering & Management, Kolkata, West Bengal, India.
  2. Debasmita Bhattacharya: Department of Basic Science and Humanities, Institute of Engineering and Management, Kolkata, Salt Lake, University of Engineering & Management, Kolkata, West Bengal, India.
  3. Sayantani Garai: Department of Biotechnology, Institute of Engineering and Management, Kolkata, New Town, University of Engineering & Management, Kolkata, West Bengal, India.
  4. Bandita Dutta: Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Haringhata, West Bengal, India.
  5. Sreejita Ghosh: Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Haringhata, West Bengal, India.
  6. Rina Rani Ray: Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Haringhata, West Bengal, India.
  7. Dibyajit Lahiri: Department of Biotechnology, Institute of Engineering and Management, Kolkata, New Town, University of Engineering & Management, Kolkata, West Bengal, India. dibyajit.lahiri@uem.edu.in.
PMID: 38536433 DOI: 10.1007/s00210-024-03056-0

Abstract

Colonisation of sessile bacterial species on biotic and abiotic surfaces is responsible for the development of various infections in humans. At present, biofilm-associated chronic infections have been a prime concern among the healthcare practitioners since they are impermeable to drugs, resulting in the development of antibiotic resistance or multi-drug resistance. For a few decades, a lot of research activity has been performed in the development of alternative therapeutics to combat biofilm-associated chronic infections. The presence of extracellular polymeric substance (EPS) prevents the permeation of most of the drugs rendering drug failures. The use of small molecules has been necessary to penetrate easily through the EPS and act on the targeted cells. In present days, the use of antimicrobial peptides (AMPs) has gained immense importance as alternative therapeutics since they exhibit a novel class of antibiotics exhibiting a wide spectrum of activity and possess a low rate of development of resistance. In the last few decades, a large number of AMPs have been identified from varied groups of organisms as effector molecules for innate immune system acting as an important line of defence. In this review, we will discuss the use of AMPs as effective agents to combat various biofilm-associated chronic infections.

Keywords

Antibiofilm Antimicrobial peptide Eradication Mechanism

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MeSH Term

Biofilms
Humans
Antimicrobial Peptides
Animals
Anti-Bacterial Agents
Down-Regulation

Chemicals

Antimicrobial Peptides
Anti-Bacterial Agents
Journal Article Review

Word Cloud

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