Phage Delivery Strategies for Biocontrolling Human, Animal, and Plant Bacterial Infections: State of the Art.

Marta M D C Vila, Liliane M N Balcão, Victor M Balcão
Author Information
  1. Marta M D C Vila: VBlab-Laboratory of Bacterial Viruses, University of Sorocaba, Sorocaba 18023-000, SP, Brazil.
  2. Liliane M N Balcão: VBlab-Laboratory of Bacterial Viruses, University of Sorocaba, Sorocaba 18023-000, SP, Brazil.
  3. Victor M Balcão: VBlab-Laboratory of Bacterial Viruses, University of Sorocaba, Sorocaba 18023-000, SP, Brazil. ORCID

Abstract

This review aims at presenting the main strategies that are currently available for the delivery of bacteriophages to combat bacterial infections in humans, animals, and plants. It can be seen that the main routes for phage delivery are topical, oral, systemic, and airways for humans. In animals, the topical and oral routes are the most used. To combat infections in plant species, spraying the plant's phyllosphere or drenching the soil are the most commonly used methods. In both phage therapy and biocontrol using phages, very promising results have been obtained so far. However, more experiments are needed to establish forms of treatment and phage doses, among other parameters. Furthermore, in general, there is a lack of specific standards for the use of phages to combat bacterial infections.

Keywords

References

  1. Int J Antimicrob Agents. 2019 Jan;53(1):16-21 [PMID: 30236954]
  2. J Heart Lung Transplant. 2019 Apr;38(4):475-476 [PMID: 30661974]
  3. Viruses. 2021 Sep 25;13(10): [PMID: 34696362]
  4. Adv Colloid Interface Sci. 2017 Nov;249:100-133 [PMID: 28688779]
  5. PLoS One. 2016 Apr 26;11(4):e0153777 [PMID: 27115154]
  6. J Aerosol Med Pulm Drug Deliv. 2013 Dec;26(6):317-35 [PMID: 23597003]
  7. Future Microbiol. 2021 Feb;16(3):135-142 [PMID: 33538181]
  8. J Microbiol Biotechnol. 2012 Dec;22(12):1613-20 [PMID: 23221522]
  9. Microorganisms. 2023 Feb 28;11(3): [PMID: 36985194]
  10. Sovrem Tekhnologii Med. 2021;13(2):32-38 [PMID: 34513074]
  11. Antibiotics (Basel). 2020 Oct 29;9(11): [PMID: 33138253]
  12. Antibiotics (Basel). 2018 Jul 27;7(3): [PMID: 30060506]
  13. Microorganisms. 2016 Jan 05;4(1): [PMID: 27681898]
  14. Poult Sci. 2020 Feb;99(2):670-677 [PMID: 32029153]
  15. Front Microbiol. 2020 Apr 22;11:732 [PMID: 32390981]
  16. Colloids Surf B Biointerfaces. 2017 Oct 1;158:182-189 [PMID: 28692873]
  17. Viruses. 2022 Dec 02;14(12): [PMID: 36560706]
  18. Virol Sin. 2017 Dec;32(6):476-484 [PMID: 29168148]
  19. Open Forum Infect Dis. 2020 Aug 27;7(9):ofaa389 [PMID: 33005701]
  20. Antibiotics (Basel). 2021 Apr 11;10(4): [PMID: 33920369]
  21. Int J Mol Sci. 2022 Dec 25;24(1): [PMID: 36613768]
  22. Antimicrob Agents Chemother. 2019 Dec 20;64(1): [PMID: 31527029]
  23. J Anim Sci. 2021 Jul 1;99(7): [PMID: 34196704]
  24. EBioMedicine. 2016 Jan 05;4:124-37 [PMID: 26981577]
  25. Expert Opin Drug Deliv. 2015;12(9):1411-24 [PMID: 25937143]
  26. Clin Microbiol Rev. 2019 Jan 16;32(2): [PMID: 30651225]
  27. Int J Low Extrem Wounds. 2019 Jun;18(2):171-175 [PMID: 31081402]
  28. Pharmaceutics. 2022 Oct 30;14(11): [PMID: 36365162]
  29. Res Vet Sci. 2021 Mar;135:42-58 [PMID: 33440244]
  30. Plant Dis. 2003 Aug;87(8):949-954 [PMID: 30812801]
  31. Front Microbiol. 2020 Dec 21;11:591021 [PMID: 33408703]
  32. Animals (Basel). 2022 May 10;12(10): [PMID: 35625078]
  33. BMC Res Notes. 2021 Sep 27;14(1):381 [PMID: 34579784]
  34. Sci Rep. 2021 Aug 2;11(1):15603 [PMID: 34341399]
  35. Appl Microbiol Biotechnol. 2023 Jun;107(11):3801-3815 [PMID: 37074382]
  36. Front Microbiol. 2019 Apr 04;10:689 [PMID: 31019499]
  37. Antibiotics (Basel). 2023 Apr 13;12(4): [PMID: 37107113]
  38. Viruses. 2021 Sep 11;13(9): [PMID: 34578390]
  39. Polymers (Basel). 2021 Mar 16;13(6): [PMID: 33809719]
  40. J Control Release. 2023 Dec;364:159-173 [PMID: 37866403]
  41. Open Forum Infect Dis. 2018 Oct 24;5(11):ofy269 [PMID: 30474047]
  42. Microb Pathog. 2023 Aug;181:106199 [PMID: 37336428]
  43. Appl Environ Microbiol. 2020 Dec 11;87(5): [PMID: 33310718]
  44. J Control Release. 2022 Jul;347:414-424 [PMID: 35569589]
  45. Pathogens. 2019 Jul 12;8(3): [PMID: 31336985]
  46. FEMS Microbiol Rev. 2021 Sep 8;45(5): [PMID: 33784387]
  47. Res Microbiol. 2018 Nov;169(9):522-530 [PMID: 29886256]
  48. Animals (Basel). 2020 May 18;10(5): [PMID: 32443410]
  49. Antibiotics (Basel). 2020 May 09;9(5): [PMID: 32397354]
  50. Can J Microbiol. 2017 Nov;63(11):865-879 [PMID: 28863269]
  51. World J Gastrointest Pharmacol Ther. 2017 Aug 6;8(3):162-173 [PMID: 28828194]
  52. Infection. 2019 Aug;47(4):665-668 [PMID: 31102236]
  53. Pharmaceutics. 2022 Sep 13;14(9): [PMID: 36145682]
  54. Nanomedicine. 2020 Feb;24:102145 [PMID: 31857183]
  55. Vet Microbiol. 2010 Dec 15;146(3-4):309-13 [PMID: 20627620]
  56. Front Microbiol. 2018 Sep 12;9:2172 [PMID: 30258426]
  57. FEMS Microbiol Lett. 2016 Feb;363(3): [PMID: 26691737]
  58. Future Microbiol. 2020 Jul;15:881-896 [PMID: 32716215]
  59. J Food Sci Technol. 2016 Mar;53(3):1355-62 [PMID: 27570260]
  60. Antibiotics (Basel). 2023 Jun 05;12(6): [PMID: 37370331]
  61. Viruses. 2018 Apr 19;10(4): [PMID: 29671810]
  62. Int J Mol Sci. 2022 Sep 18;23(18): [PMID: 36142829]
  63. Nat Rev Mater. 2016 Dec;1(12): [PMID: 29657852]
  64. Vet Dermatol. 2021 Dec;32(6):587-e158 [PMID: 33870572]
  65. Polymers (Basel). 2022 Feb 04;14(3): [PMID: 35160602]
  66. Plant Pathol J. 2020 Jun 1;36(3):204-217 [PMID: 32547337]
  67. PLoS Biol. 2023 May 23;21(5):e3002119 [PMID: 37220114]
  68. Front Cell Infect Microbiol. 2022 Jun 17;12:907314 [PMID: 35782148]
  69. Artif Cells Nanomed Biotechnol. 2017 Mar;45(2):357-363 [PMID: 27018340]
  70. Front Microbiol. 2017 Apr 04;8:449 [PMID: 28421038]
  71. ERJ Open Res. 2021 Nov 08;7(4): [PMID: 34760998]
  72. Microbiol Res. 2018 Jul - Aug;212-213:38-58 [PMID: 29853167]
  73. Curr Rev Clin Exp Pharmacol. 2021;16(1):17-29 [PMID: 32223736]
  74. Polymers (Basel). 2021 Aug 09;13(16): [PMID: 34451188]
  75. PLoS One. 2017 Oct 12;12(10):e0186239 [PMID: 29023522]
  76. Acta Biomed. 2020 Nov 09;91(13-S):e2020023 [PMID: 33170166]
  77. Animals (Basel). 2022 Nov 09;12(22): [PMID: 36428315]
  78. Pharmaceutics. 2022 Jul 07;14(7): [PMID: 35890320]
  79. Nanomedicine. 2017 Nov;13(8):2475-2484 [PMID: 28842374]
  80. Antibiotics (Basel). 2019 Aug 27;8(3): [PMID: 31461990]
  81. Front Microbiol. 2018 Aug 29;9:2021 [PMID: 30210484]
  82. J Infect. 2021 Sep;83(3):e1-e3 [PMID: 34058260]
  83. Viruses. 2022 Aug 28;14(9): [PMID: 36146712]
  84. Viruses. 2021 Nov 23;13(12): [PMID: 34960617]
  85. Adv Drug Deliv Rev. 2015 Oct 1;93:25-41 [PMID: 25312675]
  86. Appl Microbiol Biotechnol. 2020 Feb;104(3):1319-1330 [PMID: 31853568]
  87. Planta. 2021 Jan 27;253(2):49 [PMID: 33502587]
  88. Poult Sci. 2019 Oct 1;98(10):5054-5063 [PMID: 31073590]
  89. Front Microbiol. 2020 Sep 18;11:538060 [PMID: 33072008]
  90. AMB Express. 2019 Jun 17;9(1):87 [PMID: 31209685]
  91. Int J Pharm. 2019 Dec 15;572:118779 [PMID: 31740093]
  92. Microorganisms. 2022 Feb 22;10(3): [PMID: 35336061]
  93. Viruses. 2021 Feb 21;13(2): [PMID: 33670028]
  94. Transl Res. 2020 Jun;220:153-166 [PMID: 32268129]
  95. Viruses. 2021 Jun 21;13(6): [PMID: 34205687]
  96. Molecules. 2022 Mar 13;27(6): [PMID: 35335222]
  97. Sci Rep. 2017 Jan 25;7:41441 [PMID: 28120922]
  98. Curr Opin Biotechnol. 2021 Apr;68:60-71 [PMID: 33176252]
  99. Eur Rev Med Pharmacol Sci. 2021 Dec;25(1 Suppl):101-107 [PMID: 34890040]
  100. Curr Opin Infect Dis. 2020 Aug;33(4):298-303 [PMID: 32657966]
  101. Antibiotics (Basel). 2022 Aug 18;11(8): [PMID: 36009986]
  102. Viruses. 2018 Apr 25;10(5): [PMID: 29693561]
  103. Front Vet Sci. 2023 Jan 11;9:1101872 [PMID: 36713855]
  104. Front Microbiol. 2018 Mar 29;9:561 [PMID: 29651276]
  105. PLoS One. 2017 Jul 27;12(7):e0182121 [PMID: 28750102]
  106. Front Vet Sci. 2022 Dec 22;9:1058115 [PMID: 36619945]
  107. Front Cell Infect Microbiol. 2022 Aug 04;12:941867 [PMID: 35992162]
  108. Arch Virol. 2023 Aug 7;168(9):222 [PMID: 37548749]
  109. J Anim Sci Biotechnol. 2021 Apr 16;12(1):49 [PMID: 33858501]
  110. Adv Drug Deliv Rev. 2018 Aug;133:76-86 [PMID: 30096336]
  111. Int J Pharm. 2021 Aug 10;605:120850 [PMID: 34216771]
  112. Front Pharmacol. 2021 Oct 05;12:699054 [PMID: 34675801]
  113. Pharmaceuticals (Basel). 2021 Apr 13;14(4): [PMID: 33924739]
  114. Virol J. 2019 Dec 12;16(1):155 [PMID: 31831017]
  115. Pharmaceuticals (Basel). 2021 Jan 05;14(1): [PMID: 33466546]
  116. Int J Microbiol. 2012;2012:326452 [PMID: 22934116]
  117. Animals (Basel). 2022 Jan 08;12(2): [PMID: 35049766]
  118. Cell. 2022 May 26;185(11):1860-1874.e12 [PMID: 35568033]
  119. Curr Microbiol. 2017 Feb;74(2):277-283 [PMID: 27896482]
  120. Nat Commun. 2022 Jul 22;13(1):4239 [PMID: 35869081]
  121. Infect Drug Resist. 2021 Jan 06;14:17-31 [PMID: 33442273]
  122. J Basic Microbiol. 2019 Feb;59(2):123-133 [PMID: 30485461]
  123. Viruses. 2019 Jun 27;11(7): [PMID: 31252683]
  124. Burns. 2017 Nov;43(7):1532-1543 [PMID: 28502784]
  125. Curr Pharm Biotechnol. 2010 Jan;11(1):2-14 [PMID: 20214604]
  126. Pharmaceuticals (Basel). 2022 Jan 31;15(2): [PMID: 35215290]
  127. Biodes Res. 2023 Jan 16;5:0004 [PMID: 37849463]
  128. Cell. 2023 Jan 5;186(1):17-31 [PMID: 36608652]
  129. Pharmaceuticals (Basel). 2021 May 02;14(5): [PMID: 34063218]
  130. Antimicrob Agents Chemother. 2017 Sep 22;61(10): [PMID: 28807909]
  131. Curr Issues Mol Biol. 2021;40:267-302 [PMID: 32644048]
  132. Viruses. 2020 Jul 10;12(7): [PMID: 32664206]
  133. Viruses. 2022 Nov 11;14(11): [PMID: 36423108]
  134. Colloids Surf B Biointerfaces. 2014 Nov 1;123:478-85 [PMID: 25311964]
  135. Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0082421 [PMID: 34662188]
  136. Antibiotics (Basel). 2023 May 31;12(6): [PMID: 37370307]
  137. Virol J. 2017 Sep 16;14(1):179 [PMID: 28915819]
  138. Viruses. 2021 Jan 05;13(1): [PMID: 33466377]
  139. Mater Adv. 2023 Jan 31;4(5):1249-1257 [PMID: 36895585]
  140. Front Microbiol. 2023 Mar 21;14:1136638 [PMID: 37025628]
  141. Plant Dis. 2017 May;101(5):761-765 [PMID: 30678580]
  142. Plant Dis. 2007 Jul;91(7):871-878 [PMID: 30780399]
  143. Vet Res. 2021 Sep 14;52(1):118 [PMID: 34521472]
  144. Can J Infect Dis Med Microbiol. 2007 Jan;18(1):15-8 [PMID: 18923688]
  145. Pharmaceutics. 2019 Sep 14;11(9): [PMID: 31540028]
  146. Pharmaceuticals (Basel). 2017 Apr 30;10(2): [PMID: 28468287]
  147. Microorganisms. 2020 Jun 29;8(7): [PMID: 32610695]
  148. Front Microbiol. 2017 Jan 20;8:34 [PMID: 28163700]
  149. Poult Sci. 2017 Feb 1;96(2):295-302 [PMID: 27702916]
  150. Enzyme Microb Technol. 2023 Dec;171:110325 [PMID: 37716050]
  151. Antibiotics (Basel). 2021 May 11;10(5): [PMID: 34064754]
  152. Viruses. 2022 Jan 18;14(2): [PMID: 35215763]
  153. Front Microbiol. 2022 Sep 15;13:979610 [PMID: 36188006]
  154. Antibiotics (Basel). 2021 Jul 27;10(8): [PMID: 34438964]
  155. Viruses. 2020 Feb 20;12(2): [PMID: 32093349]
  156. Methods Mol Biol. 2018;1734:113-127 [PMID: 29288451]
  157. Antibiotics (Basel). 2021 Jun 28;10(7): [PMID: 34203362]
  158. Poult Sci. 2016 Dec 1;95(12):2911-2920 [PMID: 27587723]
  159. Int J Biol Macromol. 2020 Dec 1;164:4466-4474 [PMID: 32890556]
  160. Bacteriophage. 2012 Oct 1;2(4):208-214 [PMID: 23531902]
  161. Appl Biochem Biotechnol. 2014 Nov;174(6):2031-47 [PMID: 25163882]
  162. Skin Health Dis. 2022 Jan 28;2(2):e93 [PMID: 35677920]
  163. Biology (Basel). 2023 Jul 28;12(8): [PMID: 37626946]
  164. Biologics. 2022 Oct 06;16:173-186 [PMID: 36225325]
  165. BMJ Open Respir Res. 2023 May;10(1): [PMID: 37160359]
  166. J Infect Dis. 2015 Jul 15;212(2):325-34 [PMID: 25605867]
  167. Nanomaterials (Basel). 2021 Apr 22;11(5): [PMID: 33922004]
  168. ACS Infect Dis. 2021 Aug 13;7(8):2093-2101 [PMID: 33818076]
  169. Pharmaceuticals (Basel). 2018 Feb 26;11(1): [PMID: 29495355]

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