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Epigenomics
2024;16 (10): 701-714.

Epigenetics and suicide: investigating altered H3K14ac unveiled differential expression in ,  and .

Iris Šalamon Arčan, Katarina Kouter, Tomaž Zupanc, Alja Videtič Paska
Author Information
  1. Iris Šalamon Arčan: Institute of Biochemistry & Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. ORCID
  2. Katarina Kouter: Institute of Biochemistry & Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. ORCID
  3. Tomaž Zupanc: Institute of Forensic Medicine, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. ORCID
  4. Alja Videtič Paska: Institute of Biochemistry & Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. ORCID
PMID: 38545853 DOI: 10.2217/epi-2023-0351

Abstract

Environmental factors make an important contribution to suicide. Histone tails are prone to different modifications, leading to changes of chromatin (de)condensation and consequently gene expression. Level of H3K14ac was studied with chromatin immunoprecipitation followed by high-throughput DNA sequencing. Genes were further validated with RT-qPCR; using hippocampal tissue. We showed lowered H3K14ac levels in individuals who died by suicide. The genes ,  and showed differential expression in individuals who died by suicide. Identified genetic and protein interactions among genes show interactions with suicide-related genes. Further investigations of histone modifications in association with DNA methylation and miRNA are needed to expand our knowledge of the genes that could significantly contribute to suicide.

Keywords

ADORA2A B4GALT2 ChIP-seq H3K14ac MMP14 chromatin immunoprecipitation epigenetics sequencing suicide

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Grants

  1. Research Programme P1-0390, Young Researcher grant/Javna Agencija za Raziskovalno Dejavnost RS

MeSH Term

Humans
Epigenesis, Genetic
Histones
Suicide
Male
Receptor, Adenosine A2A
Female
Acetylation
Adult
Middle Aged
Hippocampus

Chemicals

Histones
Receptor, Adenosine A2A
Journal Article
Article has an altmetric score of 2

Word Cloud

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