Preparation of a novel antibacterial magnesium carbonate coating on a titanium surface and its biocompatibility.
Shougang Xiang, Chengdong Zhang, Zhenju Guan, Xingping Li, Yumei Liu, Gang Feng, Xuwei Luo, Bo Zhang, Jie Weng, Dongqin Xiao
Author Information
Shougang Xiang: Department of Orthopaedics, Research Institute of Tissue Engineering and Stem Cells, Nanchong Central Hospital (Beijing Anzhen Hospital Nanchong Hospital), The Second Clinical College of North Sichuan Medical College Nanchong Sichuan 637000 China xiaodongqin@nsmc.edu.cn 1138340730@qq.com. ORCID
Chengdong Zhang: Key Laboratory of Advanced Technologies of Materials (MOE), School of Materials Science and Engineering, Southwest Jiaotong University Chengdu Sichuan 610031 China.
Zhenju Guan: Department of Orthopaedics, Research Institute of Tissue Engineering and Stem Cells, Nanchong Central Hospital (Beijing Anzhen Hospital Nanchong Hospital), The Second Clinical College of North Sichuan Medical College Nanchong Sichuan 637000 China xiaodongqin@nsmc.edu.cn 1138340730@qq.com.
Xingping Li: Department of Orthopaedics, Chengfei Hospital Chengdu Sichuan 610091 China.
Yumei Liu: Collaboration Innovation Center for Tissue Repair Material Engineering Technology, China West Normal University Nanchong Sichuan 637002 China liuyumei@cwnu.edu.cn.
Gang Feng: Department of Orthopaedics, Research Institute of Tissue Engineering and Stem Cells, Nanchong Central Hospital (Beijing Anzhen Hospital Nanchong Hospital), The Second Clinical College of North Sichuan Medical College Nanchong Sichuan 637000 China xiaodongqin@nsmc.edu.cn 1138340730@qq.com.
Xuwei Luo: Department of Orthopaedics, Research Institute of Tissue Engineering and Stem Cells, Nanchong Central Hospital (Beijing Anzhen Hospital Nanchong Hospital), The Second Clinical College of North Sichuan Medical College Nanchong Sichuan 637000 China xiaodongqin@nsmc.edu.cn 1138340730@qq.com.
Bo Zhang: Department of Orthopaedics, Research Institute of Tissue Engineering and Stem Cells, Nanchong Central Hospital (Beijing Anzhen Hospital Nanchong Hospital), The Second Clinical College of North Sichuan Medical College Nanchong Sichuan 637000 China xiaodongqin@nsmc.edu.cn 1138340730@qq.com.
Jie Weng: Key Laboratory of Advanced Technologies of Materials (MOE), School of Materials Science and Engineering, Southwest Jiaotong University Chengdu Sichuan 610031 China.
Dongqin Xiao: Department of Orthopaedics, Research Institute of Tissue Engineering and Stem Cells, Nanchong Central Hospital (Beijing Anzhen Hospital Nanchong Hospital), The Second Clinical College of North Sichuan Medical College Nanchong Sichuan 637000 China xiaodongqin@nsmc.edu.cn 1138340730@qq.com.
Magnesium-based coatings have attracted great attention in surface modification of titanium implants due to their superior angiogenic and osteogenic properties. However, their biological effects as a carbonate-based constituent remain unrevealed. In this study, magnesium carbonate coatings were prepared on titanium surfaces under hydrothermal conditions and subsequently treated with hydrogen peroxide. Also, their antibacterial activity and cell biocompatibility were evaluated. The obtained coatings consisted of nanoparticles without cracks and exhibited excellent adhesion to the substrate. X-ray diffraction (XRD) results indicated pure magnesium carbonate coatings formed on the Ti surface after hydrothermal treatment. After hydrogen peroxide treatment, the phase composition of the coatings had no obvious change. Compared to the untreated coatings, the hydrogen peroxide-treated coatings showed increased surface roughness and hydrophilicity. Co-culture with () demonstrated that the obtained coatings had good antibacterial activity. cell culture results showed that the hydrogen peroxide-treated coatings enhanced the viability, proliferation, and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). These findings suggest that this MgCO-based coating exhibits excellent antibacterial performance and osteogenic potential. Based on the above, this study provides a simple method for preparing titanium implants with dual antibacterial and osteogenic capabilities, holding great promise in clinical applications.
