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GE Portuguese journal of gastroenterology
Apr, 2024;31 (2): 129-135.

Persistent Fever after COVID-19 Vaccination in a Patient with Ulcerative Colitis: A Call for Attention.

Cláudio Melo Rodrigues, Ana Catarina Carvalho, Sofia Ventura, Ângela Pinto Domingues, Américo Silva, Paula Ministro
Author Information
  1. Cláudio Melo Rodrigues: Department of Gastroenterology, Centro Hospitalar Tondela-Viseu, Viseu, Portugal.
  2. Ana Catarina Carvalho: Department of Gastroenterology, Centro Hospitalar Tondela-Viseu, Viseu, Portugal.
  3. Sofia Ventura: Department of Gastroenterology, Centro Hospitalar Tondela-Viseu, Viseu, Portugal.
  4. Ângela Pinto Domingues: Department of Gastroenterology, Centro Hospitalar Tondela-Viseu, Viseu, Portugal.
  5. Américo Silva: Department of Gastroenterology, Centro Hospitalar Tondela-Viseu, Viseu, Portugal.
  6. Paula Ministro: Department of Gastroenterology, Centro Hospitalar Tondela-Viseu, Viseu, Portugal.
PMID: 38572438 DOI: 10.1159/000530834

Abstract

The development of vaccinations has been game-changing in the ongoing effort to combat the COVID-19 pandemic. Until now, adverse effects are being reported at low frequency, including thrombocytopenia and myocarditis. Careful monitoring for any suspicious symptoms and signs following vaccination is necessary. We report a case of hemophagocytic lymphohistiocytosis (HLH) after mRNA COVID-19 vaccine in a 23-year-old female with ulcerative colitis. Diagnosis was made according to HLH-2004 criteria and the patient was treated with dexamethasone with response. Our report aimed to draw attention to the potential relation between COVID-19 vaccines and HLH and the necessity of continued surveillance, especially in at-risk populations such as those with underlying immune dysregulation.

Keywords

COVID-19 vaccination Hemophagocytic lymphohistiocytosis Ulcerative colitis

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Journal Article

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