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Physiology (Bethesda, Md.)
09 01, 2024;39 (5): 0.

Unraveling the Enigma of Organismal Death: Insights, Implications, and Unexplored Frontiers.

Peter A Noble, Alexander Pozhitkov, Kanhaiya Singh, Erik Woods, Chunyu Liu, Michael Levin, Gulnaz Javan, Jun Wan, Ahmed Safwat Abouhashem, Shomita S Mathew-Steiner, Chandan K Sen
Author Information
  1. Peter A Noble: Department of Microbiology, University of Alabama Birmingham, Birmingham, Alabama, United States. ORCID
  2. Alexander Pozhitkov: Division of Research Informatics, Beckman Research Institute, City of Hope, Duarte, California, United States.
  3. Kanhaiya Singh: Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
  4. Erik Woods: Ossium Health, Indianapolis, Indiana, United States.
  5. Chunyu Liu: Institute for Human Performance, Upstate Medical University, Syracuse, New York, United States.
  6. Michael Levin: Department of Biology, Tufts University, Medford, Massachusetts, United States.
  7. Gulnaz Javan: Department of Physical and Forensic Sciences, Alabama State University, Montgomery, Alabama, United States. ORCID
  8. Jun Wan: Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
  9. Ahmed Safwat Abouhashem: Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States.
  10. Shomita S Mathew-Steiner: Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
  11. Chandan K Sen: Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
PMID: 38624244 DOI: 10.1152/physiol.00004.2024

Abstract

Significant knowledge gaps exist regarding the responses of cells, tissues, and organs to organismal death. Examining the survival mechanisms influenced by metabolism and environment, this research has the potential to transform regenerative medicine, redefine legal death, and provide insights into life's physiological limits, paralleling inquiries in embryogenesis.

Keywords

organismal death physiological limits survival mechanisms transformation transitions

References

  1. Adv Sci (Weinh). 2024 Jan;11(4):e2303575 [PMID: 38032125]
  2. Diabetes Care. 2022 Sep 1;45(9):2159-2162 [PMID: 35852358]
  3. Anim Cogn. 2023 Nov;26(6):1865-1891 [PMID: 37204591]
  4. Transplant Cell Ther. 2023 Feb;29(2):95.e1-95.e10 [PMID: 36402456]
  5. Ann N Y Acad Sci. 2022 May;1511(1):5-21 [PMID: 35181885]
  6. Nature. 2019 Apr;568(7752):336-343 [PMID: 30996318]
  7. Front Microbiol. 2020 Dec 08;11:569630 [PMID: 33363519]
  8. J Neural Transm. 1985;61(3-4):253-64 [PMID: 3989524]
  9. BMC Genomics. 2018 Sep 14;19(1):675 [PMID: 30217147]
  10. Front Microbiol. 2017 Oct 30;8:2096 [PMID: 29163394]
  11. Front Microbiol. 2016 Feb 24;7:225 [PMID: 26941736]
  12. J Clin Invest. 1985 Mar;75(3):1028-36 [PMID: 2984251]
  13. Cardiovasc Diabetol. 2010 Sep 14;9:51 [PMID: 20836897]
  14. Diabetes Metab Syndr Obes. 2014 Jun 23;7:211-23 [PMID: 25018643]
  15. Front Psychol. 2019 Dec 13;10:2688 [PMID: 31920779]
  16. Commun Integr Biol. 2017 Sep 6;10(4):e1329785 [PMID: 28919937]
  17. Forensic Sci Med Pathol. 2019 Mar;15(1):75-83 [PMID: 30519986]
  18. PLoS One. 2014 Mar 11;9(3):e91295 [PMID: 24618910]
  19. Cell Metab. 2015 Aug 4;22(2):239-52 [PMID: 26244933]
  20. Nat Commun. 2018 Feb 13;9(1):490 [PMID: 29440659]
  21. bioRxiv. 2023 May 15;: [PMID: 37292819]
  22. Sci Robot. 2021 Mar 31;6(52): [PMID: 34043553]
  23. J Clin Invest. 2016 Mar 1;126(3):837-53 [PMID: 26808499]
  24. Sci Rep. 2021 Mar 23;11(1):6078 [PMID: 33758256]
  25. Diabetes. 2010 Nov;59(11):2846-53 [PMID: 20699420]
  26. Int J Mol Sci. 2020 Sep 03;21(17): [PMID: 32899302]
  27. Sci Rep. 2016 Jul 14;6:29598 [PMID: 27412051]
  28. Nat Commun. 2021 Feb 17;12(1):1088 [PMID: 33597522]
  29. J Exp Biol. 2014 Apr 1;217(Pt 7):1024-39 [PMID: 24671961]
  30. Biopreserv Biobank. 2015 Oct;13(5):311-9 [PMID: 26484571]
  31. Resuscitation. 2023 Oct;191:109903 [PMID: 37423492]
  32. Bioessays. 2017 Sep;39(9): [PMID: 28787088]
  33. Biochem Biophys Res Commun. 2021 Jul 30;564:114-133 [PMID: 33162026]
  34. Open Biol. 2017 Jan;7(1): [PMID: 28123054]
  35. Proc Natl Acad Sci U S A. 2021 Dec 7;118(49): [PMID: 34845026]
  36. Nucleic Acids Res. 2013 Mar 1;41(5):2779-96 [PMID: 23307556]
  37. Front Neurosci. 2021 Mar 25;15:614142 [PMID: 33841074]
  38. J Microbiol Methods. 2014 Nov;106:1-7 [PMID: 25091187]
  39. Regeneration (Oxf). 2016 Apr 28;3(2):78-102 [PMID: 27499881]
  40. Sci Rep. 2021 Jun 21;11(1):13008 [PMID: 34155272]

Grants

  1. R16 GM149358/NIGMS NIH HHS
  2. 61742/Bill and Ann Templeton Foundation (The Bill & Ann Templeton Foundation, Inc.)
  3. R16GM149358/HHS | National Institutes of Health (NIH)
  4. EES 2011764/National Science Foundation (NSF)

MeSH Term

Humans
Animals
Death
Journal Article Review Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural
Article has an altmetric score of 991

Word Cloud

Created with Highcharts 10.0.0deathorganismalsurvivalmechanismsphysiologicallimitsSignificantknowledgegapsexistregardingresponsescellstissuesorgansExamininginfluencedmetabolismenvironmentresearchpotentialtransformregenerativemedicineredefinelegalprovideinsightslife'sparallelinginquiriesembryogenesisUnravelingEnigmaOrganismalDeath:InsightsImplicationsUnexploredFrontierstransformationtransitions

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