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Frontiers in aging neuroscience
2024;16 1371745.

Targeting shared pathways in tauopathies and age-related macular degeneration: implications for novel therapies.

Michele Rinaldi, Antonio Pezone, Gaia Italia Quadrini, Gianmarco Abbadessa, Maria Paola Laezza, Maria Laura Passaro, Antonio Porcellini, Ciro Costagliola
Author Information
  1. Michele Rinaldi: Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
  2. Antonio Pezone: Department of Biology, University of Naples Federico II, Naples, Italy.
  3. Gaia Italia Quadrini: Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
  4. Gianmarco Abbadessa: Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.
  5. Maria Paola Laezza: Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
  6. Maria Laura Passaro: Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
  7. Antonio Porcellini: Department of Biology, University of Naples Federico II, Naples, Italy.
  8. Ciro Costagliola: Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
PMID: 38633983 DOI: 10.3389/fnagi.2024.1371745

Abstract

The intricate parallels in structure and function between the human retina and the central nervous system designate the retina as a prospective avenue for understanding brain-related processes. This review extensively explores the shared physiopathological mechanisms connecting age-related macular degeneration (AMD) and proteinopathies, with a specific focus on tauopathies. The pivotal involvement of oxidative stress and cellular senescence emerges as key drivers of pathogenesis in both conditions. Uncovering these shared elements not only has the potential to enhance our understanding of intricate neurodegenerative diseases but also sets the stage for pioneering therapeutic approaches in AMD.

Keywords

Alzheimer’s disease age-related macular degeneration amyloid-β drusen oxidative stress tauopathies

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