Assessing feasibility of conducting medication review with follow-up among older adults at community pharmacy: a pilot randomised controlled trial.

Christina Malini Christopher, Ali Qais Blebil, K C Bhuvan, Deepa Alex, Mohamed Izham Mohamed Ibrahim, Norhasimah Ismail, Mark Wing Loong Cheong
Author Information
  1. Christina Malini Christopher: School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Subang Jaya, Selangor, Malaysia. christina.christopher@monash.edu. ORCID
  2. Ali Qais Blebil: School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Subang Jaya, Selangor, Malaysia.
  3. K C Bhuvan: School of Clinical Sciences, Queensland University of Technology, Brisbane, Australia.
  4. Deepa Alex: Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Subang Jaya, Selangor, Malaysia.
  5. Mohamed Izham Mohamed Ibrahim: Clinical Pharmacy and Practice Department, College of Pharmacy, QU Health, Qatar University, Doha, Qatar.
  6. Norhasimah Ismail: Bayan Lepas Health Clinic, Ministry of Health, Bayan Lepas, Penang, Malaysia.
  7. Mark Wing Loong Cheong: School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Subang Jaya, Selangor, Malaysia.

Abstract

BACKGROUND: Medication review with follow-up is essential for optimising medication utilisation among the older adult population in primary healthcare.
AIM: This study aimed to evaluate the feasibility of implementing medication reviews with follow-up for older adults in community pharmacies and examined potential outcomes on medication use.
METHOD: A pilot randomised controlled trial was conducted with 4 cluster-randomised community pharmacies to assess the feasibility of the intervention. Two community pharmacies served as intervention and control groups. Both groups recruited older adults over 60 who were followed over 6 months. The translated Medication use Questionnaire (MedUseQ) was administered at baseline and 6 months for both groups. The outcomes were to assess the feasibility of conducting medication review with follow-up and the probable medication use outcomes from the intervention.
RESULTS: The intervention and control groups comprised 14 and 13 older adults. A total of 35 recommendations were made by pharmacists in the intervention group and 8 in the control group. MedUseQ was easily administered, providing some evidence the feasibility of the intervention. However, there were feasibility challenges such as a lack of pharmacists, collaborative practice, difficulties with the tool language, time constraints, and limited funds. Questionnaire results provided a signal of improvement in medication administration, adherence, and polypharmacy among intervention participants. The incidence of drug related problems was significantly higher in the control group (median = 1) after 6 months, U = 15, z = - 2.98, p = 0.01.
CONCLUSION: Medication review with follow-up is potentialy practical in community pharmacies, but there are feasibility issues. While these challenges can be addressed, it is essential to study larger sample sizes to establish more robust evidence regarding outcomes.
CLINICAL TRIAL REGISTRY: ClinicalTrials.Gov NCT05297461.

Keywords

Associated Data

ClinicalTrials.gov | NCT05297461

References

  1. Int J Clin Pharm. 2017 Feb;39(1):33-36 [PMID: 27905074]
  2. Malays Fam Physician. 2008 Apr 30;3(1):7-13 [PMID: 25606105]
  3. J Patient Saf. 2021 Jun 1;17(4):290-298 [PMID: 30920431]
  4. Eur J Heart Fail. 2019 Aug;21(8):1012-1021 [PMID: 31129917]
  5. BMC Geriatr. 2019 Nov 27;19(1):332 [PMID: 31775650]
  6. J Am Pharm Assoc (2003). 2012 Sep-Oct;52(5):603-12 [PMID: 23023840]
  7. Stat Methods Med Res. 2016 Jun;25(3):1057-73 [PMID: 26092476]
  8. Int J Clin Pharm. 2018 Feb;40(1):109-118 [PMID: 29188412]
  9. Explor Res Clin Soc Pharm. 2021 May 03;2:100018 [PMID: 35481129]
  10. Int J Pharm Pract. 2015 Dec;23(6):379-80 [PMID: 26768826]
  11. Int J Clin Pharm. 2019 Aug;41(4):895-902 [PMID: 31073975]
  12. Res Social Adm Pharm. 2023 Apr;19(4):673-680 [PMID: 36529621]
  13. Int J Qual Health Care. 2003 Dec;15 Suppl 1:i49-59 [PMID: 14660523]
  14. Int J Pharm Pract. 2013 Feb;21(1):66-9 [PMID: 23301536]
  15. Front Pharmacol. 2013 May 29;4:69 [PMID: 23755014]
  16. Res Social Adm Pharm. 2017 Jul - Aug;13(4):661-685 [PMID: 27665364]
  17. BMC Health Serv Res. 2020 Jan 6;20(1):5 [PMID: 31902367]
  18. J Am Pharm Assoc (2003). 2016 Jan;56(1):22-8 [PMID: 26802916]
  19. J Prim Health Care. 2013 Sep 01;5(3):223-33 [PMID: 23998173]
  20. BMC Health Serv Res. 2021 Jul 4;21(1):649 [PMID: 34217293]
  21. BMJ. 2016 Oct 24;355:i5239 [PMID: 27777223]
  22. Res Social Adm Pharm. 2019 Dec;15(12):1383-1394 [PMID: 30733137]
  23. Res Social Adm Pharm. 2018 Feb;14(2):203-206 [PMID: 28236569]
  24. J Nutr Health Aging. 2014;18(2):199-203 [PMID: 24522474]
  25. Pharmacoeconomics. 2015 Jun;33(6):599-610 [PMID: 25774017]
  26. Int J Clin Pharm. 2019 Oct;41(5):1166-1173 [PMID: 31493209]
  27. BMJ Open. 2018 Jul 19;8(7):e019042 [PMID: 30030308]
  28. Int J Clin Pharm. 2016 Apr;38(2):208-12 [PMID: 26746903]
  29. Res Social Adm Pharm. 2012 May-Jun;8(3):258-62 [PMID: 21824823]
  30. CMAJ. 2003 Jul 8;169(1):17-22 [PMID: 12847034]
  31. SAGE Open Med. 2016 Jun 14;4:2050312116652568 [PMID: 27354917]
  32. Ther Adv Drug Saf. 2019 Oct 21;10:2042098619883156 [PMID: 31673327]
  33. Res Social Adm Pharm. 2022 Apr;18(4):2559-2568 [PMID: 33965357]
  34. Br J Clin Pharmacol. 2014 Jan;77(1):102-15 [PMID: 23594037]
  35. J Am Geriatr Soc. 2009 May;57(5):761-89 [PMID: 19484833]
  36. Pharm Pract (Granada). 2021 Jul-Sep;19(3):2397 [PMID: 34621450]
  37. Epidemiol Rev. 2013;35:75-83 [PMID: 23372025]
  38. Pharm Pract (Granada). 2017 Apr-Jun;15(2):933 [PMID: 28690697]
  39. J Public Health Afr. 2011 Sep 05;2(2):e23 [PMID: 28299064]
  40. J Pharm Policy Pract. 2023 Oct 9;16(1):118 [PMID: 37814349]
  41. Pharm Pract (Granada). 2020 Oct-Dec;18(4):1976 [PMID: 33224322]
  42. Br Med J (Clin Res Ed). 1981 Jun 27;282(6282):2114-7 [PMID: 6788226]
  43. Int J Clin Pharm. 2014 Feb;36(1):163-71 [PMID: 24293339]
  44. BMC Public Health. 2012 Mar 15;12:192 [PMID: 22420693]
  45. Value Health Reg Issues. 2023 May;35:34-41 [PMID: 36842337]
  46. Geriatr Nurs. 2022 Sep-Oct;47:71-80 [PMID: 35850034]

MeSH Term

Humans
Pilot Projects
Aged
Community Pharmacy Services
Feasibility Studies
Female
Male
Follow-Up Studies
Pharmacists
Aged, 80 and over
Middle Aged
Polypharmacy
Surveys and Questionnaires
Medication Reconciliation
Assessment of Medication Adherence

Word Cloud

Created with Highcharts 10.0.0medicationfeasibilityinterventionreviewfollow-upolderadultscommunityMedicationpharmaciesoutcomescontrolgroupsamonguse6monthsgroupessentialstudypilotrandomisedcontrolledtrialassessQuestionnaireMedUseQadministeredconductingpharmacistsevidencechallengesBACKGROUND:optimisingutilisationadultpopulationprimaryhealthcareAIM:aimedevaluateimplementingreviewsexaminedpotentialMETHOD:conducted4cluster-randomisedTwoservedrecruited60followedtranslatedbaselineprobableRESULTS:comprised1413total35recommendationsmade8easilyprovidingHoweverlackcollaborativepracticedifficultiestoollanguagetimeconstraintslimitedfundsresultsprovidedsignalimprovementadministrationadherencepolypharmacyparticipantsincidencedrugrelatedproblemssignificantlyhighermedian = 1U = 15 z = - 298 p =001CONCLUSION:potentialypracticalissuescanaddressedlargersamplesizesestablishrobustregardingCLINICALTRIALREGISTRY:ClinicalTrialsGovNCT05297461Assessingpharmacy:CommunitypharmacyFeasibilityOlderPilotRCT

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