OpenLB
Open Library of Bioscience
Advanced Search
Archives of microbiology
Apr 28, 2024;206 (5): 237.

Current status and new experimental diagnostic methods of invasive fungal infections after hematopoietic stem cell transplantation.

Zhenhua Tang, HaiTao Wang, Yuankai Liu, Chen Wang, Xinye Li, Qiong Yang
Author Information
  1. Zhenhua Tang: Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, 830046, China.
  2. HaiTao Wang: Department of Hematology, The Fifth Medical Center of Chinese, PLA General Hospital, Beijing, 100071, China.
  3. Yuankai Liu: Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, 100875, China.
  4. Chen Wang: Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, 100875, China.
  5. Xinye Li: Lanzhou Petrochemical General Hospital (The Fourth Affiliated Hospital of Gansu University of Chinese Medicine), Gansu, 730060, China. 278997780@qq.com.
  6. Qiong Yang: Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, 100875, China. yangqiong@bnu.edu.cn.
PMID: 38678508 DOI: 10.1007/s00203-024-03905-9

Abstract

Invasive fungal infections (IFIs) are common and life-threatening complications in post-hematopoietic stem cell transplantation (post-HSCT) recipients, Severe IFIs can lead to systemic infection and organ damage, which results in high mortality in HSCT recipients. With the development of the field of fungal infection diagnosis, more and more advanced non-culture diagnostic tools have been developed, such as glip biosensors, metagenomic next-generation sequencing, Magnetic Nanoparticles and Identified Using SERS via AgNPs , and artificial intelligence-assisted diagnosis. The advanced diagnostic approaches contribute to the success of HSCT and improve the overall survival of post-HSCT leukemia patients by supporting therapeutical decisions. This review provides an overview of the characteristics of two high-incidence IFIs in post-HSCT recipients and discusses some of the recently developed IFI detection technologies. Additionally, it explores the potential application of cationic conjugated polymer fluorescence resonance energy transfer (CCP-FRET) technology for IFI detection. The aim is to offer insights into selecting appropriate IFI detection methods and gaining an understanding of novel fungal diagnostic approaches in laboratory settings.

Keywords

Cationic conjugated polymer-based fluorescence resonance energy transfer Fungal infection detection technology Hematopoietic stem cell transplantation Invasive fungal infection

References

  1. Arvanitis M, Anagnostou T, Fuchs BB, Caliendo AM, Mylonakis E (2014) Molecular and nonmolecular diagnostic methods for invasive fungal infections. Clin Microbiol Rev 27:490–526. https://doi.org/10.1128/cmr.00091-13 [DOI: 10.1128/cmr.00091-13]
  2. Bakken IM et al (2022) The use of in vivo confocal microscopy in fungal keratitis - Progress and challenges. Ocul Surf 24:103–118. https://doi.org/10.1016/j.jtos.2022.03.002 [DOI: 10.1016/j.jtos.2022.03.002]
  3. Benedict K, Jackson BR, Chiller T, Beer KD (2019) Estimation of Direct Healthcare Costs of Fungal Diseases in the United States. Clin Infect Dis 68:1791–1797. https://doi.org/10.1093/cid/ciy776 [DOI: 10.1093/cid/ciy776]
  4. Bhatnagar I, Mahato K, Ealla KKR, Asthana A, Chandra P (2018) Chitosan stabilized gold nanoparticle mediated self-assembled gliP nanobiosensor for diagnosis of Invasive Aspergillosis. Int J Biol Macromol 110:449–456. https://doi.org/10.1016/j.ijbiomac.2017.12.084 [DOI: 10.1016/j.ijbiomac.2017.12.084]
  5. Bojang E, Ghuman H, Kumwenda P, Hall RA (2021) Immune Sensing of Candida albicans. J Fungi (basel). https://doi.org/10.3390/jof7020119 [DOI: 10.3390/jof7020119]
  6. Busca A et al (2021) Management of Invasive Fungal Infections in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: The Turin Experience. Front Cell Infect Microbiol. https://doi.org/10.3389/fcimb.2021.805514 [DOI: 10.3389/fcimb.2021.805514]
  7. Chen XC, Xu J, Wu DP (2020) Clinical Characteristics and Outcomes of Breakthrough Candidemia in 71 Hematologic Malignancy Patients and/or Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Single-center Retrospective Study From China, 2011–2018. Clin Infect Dis 71:S394-s399. https://doi.org/10.1093/cid/ciaa1523 [DOI: 10.1093/cid/ciaa1523]
  8. Chen B et al (2021) Evaluation of Droplet Digital PCR Assay for the Diagnosis of Candidemia in Blood Samples. Front Microbiol. https://doi.org/10.3389/fmicb.2021.700008 [DOI: 10.3389/fmicb.2021.700008]
  9. Choi JK et al (2017) Epidemiology and Risk Factors for Invasive Fungal Diseases among Allogeneic Hematopoietic Stem Cell Transplant Recipients in Korea: Results of “RISK” Study. Biol Blood Marrow Transplant 23:1773–1779. https://doi.org/10.1016/j.bbmt.2017.06.012 [DOI: 10.1016/j.bbmt.2017.06.012]
  10. Corzo-León DE et al (2015) Epidemiology and outcomes of invasive fungal infections in allogeneic haematopoietic stem cell transplant recipients in the era of antifungal prophylaxis: a single-centre study with focus on emerging pathogens. Mycoses 58:325–336. https://doi.org/10.1111/myc.12318 [DOI: 10.1111/myc.12318]
  11. Cotten CM, McDonald S, Stoll B, Goldberg RN, Poole K, Benjamin DK Jr (2006) The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants. Pediatrics 118:717–722. https://doi.org/10.1542/peds.2005-2677 [DOI: 10.1542/peds.2005-2677]
  12. Duan X et al (2009) Single-nucleotide polymorphism (SNP) genotyping using cationic conjugated polymers in homogeneous solution. Nat Protoc 4:984–991. https://doi.org/10.1038/nprot.2009.70 [DOI: 10.1038/nprot.2009.70]
  13. Elfeky R, Lazareva A, Qasim W, Veys P (2019) Immune reconstitution following hematopoietic stem cell transplantation using different stem cell sources. Expert Rev Clin Immunol 15:735–751. https://doi.org/10.1080/1744666x.2019.1612746 [DOI: 10.1080/1744666x.2019.1612746]
  14. Feng F, Wang H, Han L, Wang S (2008) Fluorescent conjugated polyelectrolyte as an indicator for convenient detection of DNA methylation. J Am Chem Soc 130:11338–11343. https://doi.org/10.1021/ja8011963 [DOI: 10.1021/ja8011963]
  15. Feng F, Liu L, Wang S (2010) Fluorescent conjugated polymer-based FRET technique for detection of DNA methylation of cancer cells. Nat Protoc 5:1255–1264. https://doi.org/10.1038/nprot.2010.79 [DOI: 10.1038/nprot.2010.79]
  16. Gardiner DM, Howlett BJ (2005) Bioinformatic and expression analysis of the putative gliotoxin biosynthetic gene cluster of Aspergillus fumigatus. FEMS Microbiol Lett 248:241–248. https://doi.org/10.1016/j.femsle.2005.05.046 [DOI: 10.1016/j.femsle.2005.05.046]
  17. Glampedakis E et al (2021) Invasive Aspergillosis Due to Aspergillus Section Usti: A Multicenter Retrospective Study. Clin Infect Dis 72:1379–1385. https://doi.org/10.1093/cid/ciaa230 [DOI: 10.1093/cid/ciaa230]
  18. Gu W et al (2021) Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids. Nat Med 27:115–124. https://doi.org/10.1038/s41591-020-1105-z [DOI: 10.1038/s41591-020-1105-z]
  19. Guo J, Luo Y, Wu Y, Lai W, Mu X (2019) Clinical Characteristic and Pathogen Spectrum of Neonatal Sepsis in Guangzhou City from June 2011 to June 2017. Med Sci Monit 25:2296–2304. https://doi.org/10.12659/msm.912375 [DOI: 10.12659/msm.912375]
  20. Harrison N et al (2015) Incidence and characteristics of invasive fungal diseases in allogeneic hematopoietic stem cell transplant recipients: a retrospective cohort study. BMC Infect Dis 15:584. https://doi.org/10.1186/s12879-015-1329-6 [DOI: 10.1186/s12879-015-1329-6]
  21. Hu S et al (2021) Rapid Detection Method for Pathogenic Candida Captured by Magnetic Nanoparticles and Identified Using SERS via AgNPs(). Int J Nanomedicine 16:941–950. https://doi.org/10.2147/ijn.S285339 [DOI: 10.2147/ijn.S285339]
  22. Huang J, Liu C, Zheng X (2022) Clinical features of invasive fungal disease in children with no underlying disease. Sci Rep 12:208. https://doi.org/10.1038/s41598-021-03099-w [DOI: 10.1038/s41598-021-03099-w]
  23. Köhler JR, Hube B, Puccia R, Casadevall A, Perfect JR (2017) Fungi that Infect Humans. Microbiol Spectr. https://doi.org/10.1128/microbiolspec.FUNK-0014-2016 [DOI: 10.1128/microbiolspec.FUNK-0014-2016]
  24. Lu Y et al (2023) The clinical value of Aspergillus-specific IgG antibody test in the diagnosis of nonneutropenic invasive pulmonary aspergillosis. Clin Microbiol Infect 29:797.e791-797.e797. https://doi.org/10.1016/j.cmi.2023.02.002 [DOI: 10.1016/j.cmi.2023.02.002]
  25. Ma H et al (2021) Deep convolutional neural network: a novel approach for the detection of Aspergillus fungi via stereomicroscopy. J Microbiol 59:563–572. https://doi.org/10.1007/s12275-021-1013-z [DOI: 10.1007/s12275-021-1013-z]
  26. Mendonça A, Santos H, Franco-Duarte R, Sampaio P (2022) Fungal infections diagnosis - Past, present and future. Res Microbiol. https://doi.org/10.1016/j.resmic.2021.103915 [DOI: 10.1016/j.resmic.2021.103915]
  27. Menzin J et al (2009) Mortality, length of hospitalization, and costs associated with invasive fungal infections in high-risk patients. Am J Health Syst Pharm 66:1711–1717. https://doi.org/10.2146/ajhp080325 [DOI: 10.2146/ajhp080325]
  28. Mylonakis E et al (2015) T2 magnetic resonance assay for the rapid diagnosis of candidemia in whole blood: a clinical trial. Clin Infect Dis 60:892–899. https://doi.org/10.1093/cid/ciu959 [DOI: 10.1093/cid/ciu959]
  29. Omrani AS, Almaghrabi RS (2017) Complications of hematopoietic stem transplantation: Fungal infections. Hematol Oncol Stem Cell Ther 10:239–244. https://doi.org/10.1016/j.hemonc.2017.05.013 [DOI: 10.1016/j.hemonc.2017.05.013]
  30. Papon N, Bougnoux ME, d’Enfert C (2020) Tracing the Origin of Invasive Fungal Infections. Trends Microbiol 28:240–242. https://doi.org/10.1016/j.tim.2020.01.007 [DOI: 10.1016/j.tim.2020.01.007]
  31. Pappas PG, Lionakis MS, Arendrup MC, Ostrosky-Zeichner L, Kullberg BJ (2018) Invasive Candidiasis. Nat Rev Dis Primers 4:18026. https://doi.org/10.1038/nrdp.2018.26 [DOI: 10.1038/nrdp.2018.26]
  32. Puerta-Alcalde P, Champlin RE, Kontoyiannis DP (2020) How I perform hematopoietic stem cell transplantation on patients with a history of invasive fungal disease. Blood 136:2741–2753. https://doi.org/10.1182/blood.2020005884 [DOI: 10.1182/blood.2020005884]
  33. Revie NM, Iyer KR, Robbins N, Cowen LE (2018) Antifungal drug resistance: evolution, mechanisms and impact. Curr Opin Microbiol 45:70–76. https://doi.org/10.1016/j.mib.2018.02.005 [DOI: 10.1016/j.mib.2018.02.005]
  34. Song J, Yang Q, Lv F, Liu L, Wang S (2012) Visual detection of DNA mutation using multicolor fluorescent coding. ACS Appl Mater Interfaces 4:2885–2890. https://doi.org/10.1021/am300830r [DOI: 10.1021/am300830r]
  35. Song J et al (2013) Multiplex detection of DNA mutations by the fluorescence fingerprint spectrum technique. Angew Chem Int Ed Engl 52:13020–13023. https://doi.org/10.1002/anie.201305461 [DOI: 10.1002/anie.201305461]
  36. Souza L et al (2021) Epidemiology of invasive fungal disease in haematologic patients. Mycoses 64:252–256. https://doi.org/10.1111/myc.13205 [DOI: 10.1111/myc.13205]
  37. Steinbrink JM, Hong DK, Bergin SP, Al-Rohil RN, Perfect JR, Maziarz EK (2020) The robust and rapid role of molecular testing in precision fungal diagnostics: A case report. Med Mycol Case Rep 27:77–80. https://doi.org/10.1016/j.mmcr.2020.02.003 [DOI: 10.1016/j.mmcr.2020.02.003]
  38. Sun Y et al (2015) Epidemiology, management, and outcome of invasive fungal disease in patients undergoing hematopoietic stem cell transplantation in China: a multicenter prospective observational study. Biol Blood Marrow Transplant 21:1117–1126. https://doi.org/10.1016/j.bbmt.2015.03.018 [DOI: 10.1016/j.bbmt.2015.03.018]
  39. Terrero-Salcedo D, Powers-Fletcher MV (2020) Updates in Laboratory Diagnostics for Invasive Fungal Infections. J Clin Microbiol. https://doi.org/10.1128/jcm.01487-19 [DOI: 10.1128/jcm.01487-19]
  40. Thammasit P, Sripetchwandee J, Nosanchuk JD, Chattipakorn SC, Chattipakorn N, Youngchim S (2021) Cytokine and Chemokine Responses in Invasive Aspergillosis Following Hematopoietic Stem Cell Transplantation: Past Evidence for Future Therapy of Aspergillosis. J Fungi (basel). https://doi.org/10.3390/jof7090753 [DOI: 10.3390/jof7090753]
  41. Thomas SW 3rd, Joly GD, Swager TM (2007) Chemical sensors based on amplifying fluorescent conjugated polymers. Chem Rev 107:1339–1386. https://doi.org/10.1021/cr0501339 [DOI: 10.1021/cr0501339]
  42. Valentine JC et al (2019) A population-based analysis of invasive fungal disease in haematology-oncology patients using data linkage of state-wide registries and administrative databases: 2005–2016. BMC Infect Dis 19:274. https://doi.org/10.1186/s12879-019-3901-y [DOI: 10.1186/s12879-019-3901-y]
  43. Wang J, Zhou M, Xu JY, Zhou RF, Chen B, Wan Y (2020) Comparison of Antifungal Prophylaxis Drugs in Patients With Hematological Disease or Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review and Network Meta-analysis. JAMA Netw Open. https://doi.org/10.1001/jamanetworkopen.2020.17652 [DOI: 10.1001/jamanetworkopen.2020.17652]
  44. Wang W et al (2023) Prototype early diagnostic model for invasive pulmonary aspergillosis based on deep learning and big data training. Mycoses 66:118–127. https://doi.org/10.1111/myc.13540 [DOI: 10.1111/myc.13540]
  45. Yang Q et al (2011) Simple and sensitive method for detecting point mutations of epidermal growth factor receptor using cationic conjugated polymers. ACS Appl Mater Interfaces 3:4539–4545. https://doi.org/10.1021/am201248y [DOI: 10.1021/am201248y]
  46. Yang X et al (2021) A 20-Year Antifungal Susceptibility Surveillance (From 1999 to 2019) for Aspergillus spp. and Proposed Epidemiological Cutoff Values for Aspergillus fumigatus and Aspergillus flavus: A Study in a Tertiary Hospital in China. Front Microbiol. https://doi.org/10.3389/fmicb.2021.680884 [DOI: 10.3389/fmicb.2021.680884]
  47. Yang Q et al (2021) A Rapid, Visible, and Highly Sensitive Method for Recognizing and Distinguishing Invasive Fungal Infections via CCP-FRET Technology. ACS Infect Dis 7:2816–2825. https://doi.org/10.1021/acsinfecdis.1c00393 [DOI: 10.1021/acsinfecdis.1c00393]
  48. Zhi ZXYXZ (2023) [Chinese expert consensus for invasive fungal disease in patients after hematopoietic stem cell transplantation(2023)]. 44:92–97 doi: https://doi.org/10.3760/cma.j.issn.0253-2727.2023.02.002
  49. Zhu C, Liu L, Yang Q, Lv F, Wang S (2012) Water-soluble conjugated polymers for imaging, diagnosis, and therapy. Chem Rev 112:4687–4735. https://doi.org/10.1021/cr200263w [DOI: 10.1021/cr200263w]

Grants

  1. 22072005/National Natural Science Foundation of China
  2. 22072005/National Natural Science Foundation of China
  3. 22072005/National Natural Science Foundation of China
  4. 22072005/National Natural Science Foundation of China

MeSH Term

Humans
Hematopoietic Stem Cell Transplantation
Invasive Fungal Infections
Fluorescence Resonance Energy Transfer
High-Throughput Nucleotide Sequencing
Biosensing Techniques
Journal Article Review

Word Cloud

Created with Highcharts 10.0.0fungalinfectiondiagnosticdetectionIFIsstemcelltransplantationpost-HSCTrecipientsIFIInvasiveinfectionsHSCTdiagnosisadvanceddevelopedapproachesconjugatedfluorescenceresonanceenergytransfertechnologymethodscommonlife-threateningcomplicationspost-hematopoieticSeverecanleadsystemicorgandamageresultshighmortalitydevelopmentfieldnon-culturetoolsglipbiosensorsmetagenomicnext-generationsequencingMagneticNanoparticlesIdentifiedUsingSERSviaAgNPs artificialintelligence-assistedcontributesuccessimproveoverallsurvivalleukemiapatientssupportingtherapeuticaldecisionsreviewprovidesoverviewcharacteristicstwohigh-incidencediscussesrecentlytechnologiesAdditionallyexplorespotentialapplicationcationicpolymerCCP-FRETaimofferinsightsselectingappropriategainingunderstandingnovellaboratorysettingsCurrentstatusnewexperimentalinvasivehematopoieticCationicpolymer-basedFungalHematopoietic

Similar Articles

Cited By