A Systematic Review of Trajectories of Clinically Relevant Distress Amongst Adults with Cancer: Course and Predictors.

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Leah Curran, Alison Mahoney, Bradley Hastings

Author Information

Leah Curran: Health@Business Research Network, School of Management and Governance, University of New South Wales, High Street, Kensington, Australia. l.curran@unsw.edu.au. ORCID
Alison Mahoney: Clinical Research Unit for Anxiety and Depression, St Vincent's Hospital Network, 390 Victoria Street, Darlinghurst, Australia.
Bradley Hastings: Health@Business Research Network, School of Management and Governance, University of New South Wales, High Street, Kensington, Australia.

PMID: 38704756 DOI: 10.1007/s10880-024-10011-x

To improve interventions for people with cancer who experience clinically relevant distress, it is important to understand how distress evolves over time and why. This review synthesizes the literature on trajectories of distress in adult patients with cancer. Databases were searched for longitudinal studies using a validated clinical tool to group patients into distress trajectories. Twelve studies were identified reporting trajectories of depression, anxiety, adjustment disorder or post-traumatic stress disorder. Heterogeneity between studies was high, including the timing of baseline assessments and follow-up intervals. Up to 1 in 5 people experienced persistent depression or anxiety. Eight studies examined predictors of trajectories; the most consistent predictor was physical symptoms or functioning. Due to study methodology and heterogeneity, limited conclusions could be drawn about why distress is maintained or emerges for some patients. Future research should use valid clinical measures and assess theoretically driven predictors amendable to interventions.

Cancer Distress trajectory Predictors Systematic review

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