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Analytical science advances
Apr, 2021;2 (3-4): 142-156.

Advances in high-resolution mass spectrometry applied to pharmaceuticals in 2020: A whole new age of information.

Caroline Géhin, Stephen W Holman
Author Information
  1. Caroline Géhin: Chemical Development Pharmaceutical Technology & Development Operations, AstraZeneca Macclesfield UK.
  2. Stephen W Holman: Chemical Development Pharmaceutical Technology & Development Operations, AstraZeneca Macclesfield UK. ORCID
PMID: 38716455 DOI: 10.1002/ansa.202000149

Abstract

Continuous improvements in mass spectrometry (MS) have resulted in the widespread availability and adoption of high-resolution mass spectrometry (HRMS) across laboratories worldwide. The capabilities and the associated advantages of HRMS make it an invaluable analytical tool for analyte characterization, screening, and quantification methodologies for a wide scope of applications across pharmaceutical development. These applications include drug discovery, product characterizations of both small molecules and novel drug modalities, and metabolism studies, post-approval quality control, and pharmacovigilance. This review gives an overview of the current capabilities of HRMS and its pharmaceutical applications in 2020, and provides a perspective on the future of HRMS within the pharmaceutical industry.

Keywords

HRMS MS high‐resolution mass spectrometry pharma pharmaceutical

References

  1. Int J Mol Sci. 2015 Dec 02;16(12):28566-81 [PMID: 26633379]
  2. Rapid Commun Mass Spectrom. 2020 Jun 30;34(12):e8799 [PMID: 32247289]
  3. Proteomics Clin Appl. 2013 Jan;7(1-2):171-80 [PMID: 23184895]
  4. Lancet. 2018 Feb 3;391(10119):462-512 [PMID: 29056410]
  5. Cell. 2020 Aug 6;182(3):685-712.e19 [PMID: 32645325]
  6. Anal Chem. 2014 Jun 3;86(11):5316-22 [PMID: 24841326]
  7. Annu Rev Anal Chem (Palo Alto Calif). 2011;4:1-22 [PMID: 21351881]
  8. Expert Rev Proteomics. 2012 Oct;9(5):505-17 [PMID: 23194268]
  9. J Chromatogr A. 2020 Oct 11;1629:461496 [PMID: 32846341]
  10. Neurosci Res. 2017 Feb;115:1-4 [PMID: 27876581]
  11. Angew Chem Int Ed Engl. 2017 Aug 21;56(35):10294-10323 [PMID: 28186380]
  12. Lancet. 2020 Oct 31;396(10260):e71-e72 [PMID: 33069277]
  13. PLoS One. 2020 Jul 9;15(7):e0235458 [PMID: 32645044]
  14. J Pharm Biomed Anal. 2020 Jan 5;177:112732 [PMID: 31568965]
  15. J Ethnopharmacol. 2020 May 10;253:112659 [PMID: 32058009]
  16. J Chromatogr A. 2020 May 10;1618:460850 [PMID: 31983414]
  17. J Pharm Biomed Anal. 2020 Jun 5;185:113199 [PMID: 32146287]
  18. Metabolites. 2020 Apr 18;10(4): [PMID: 32325648]
  19. Alzheimers Dement (N Y). 2017 Nov 11;3(4):651-657 [PMID: 29255791]
  20. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18132-8 [PMID: 18818311]
  21. J Anal Toxicol. 2020 Jul 31;44(6):541-548 [PMID: 31898746]
  22. Biomed Chromatogr. 2020 Aug;34(8):e4855 [PMID: 32304111]
  23. Sci Rep. 2020 Apr 2;10(1):5808 [PMID: 32242073]
  24. ACS Cent Sci. 2020 Jul 22;6(7):1223-1230 [PMID: 32724856]
  25. Environ Sci Technol. 2014 Jul 15;48(14):7683-9 [PMID: 24915506]
  26. J Am Soc Mass Spectrom. 2019 Feb;30(2):203-212 [PMID: 30560541]
  27. J Pharm Biomed Anal. 2020 Jul 15;186:113271 [PMID: 32247161]
  28. Sci Total Environ. 2014 Mar 1;473-474:619-41 [PMID: 24394371]
  29. EBioMedicine. 2018 Oct;36:553-562 [PMID: 30224312]
  30. Metabolites. 2020 Mar 16;10(3): [PMID: 32188118]
  31. Environ Sci Technol. 2020 Jan 21;54(2):889-901 [PMID: 31887037]
  32. J Chromatogr A. 2020 Mar 15;1614:460716 [PMID: 31761437]
  33. Eur Respir J. 2020 Feb 27;55(2): [PMID: 31515400]
  34. J Am Soc Mass Spectrom. 2017 Jan 1;28(1):5-13 [PMID: 32020797]
  35. Proteomics Clin Appl. 2015 Apr;9(3-4):423-31 [PMID: 25504492]
  36. Anal Sci Adv. 2021 Jan 29;2(3-4):142-156 [PMID: 38716455]
  37. Biomed Chromatogr. 2000 Oct;14(6):373-83 [PMID: 11002275]
  38. Front Chem. 2020 Aug 26;8:626 [PMID: 33005598]
  39. J Pharm Biomed Anal. 2020 Nov 30;191:113591 [PMID: 32889346]
  40. Medicines (Basel). 2019 Jan 18;6(1): [PMID: 30669335]
  41. AAPS J. 2020 Jul 1;22(4):89 [PMID: 32613429]
  42. Eur J Pharm Sci. 2020 Dec 1;155:105544 [PMID: 32927068]
  43. Analyst. 2020 Feb 17;145(4):1129-1157 [PMID: 31971527]
  44. Anal Chim Acta. 2020 Aug 15;1125:279-287 [PMID: 32674774]
  45. Science. 2020 Jan 24;367(6476):392-396 [PMID: 31974245]
  46. ACS Med Chem Lett. 2020 Jan 14;11(3):228-231 [PMID: 32184948]
  47. J Pharm Biomed Anal. 2020 May 30;184:113169 [PMID: 32092629]
  48. J Hazard Mater. 2020 Apr 5;387:121712 [PMID: 31784138]
  49. Anal Bioanal Chem. 2020 Sep;412(23):5729-5741 [PMID: 32642835]
  50. J Mass Spectrom. 2020 Mar;55(3):e4497 [PMID: 31918453]
  51. J Pharm Anal. 2020 Jun;10(3):240-246 [PMID: 32612870]
  52. Mol Cell Proteomics. 2020 Apr;19(4):716-729 [PMID: 32051234]
  53. Sci Rep. 2020 Aug 12;10(1):13619 [PMID: 32788674]
  54. Anal Chim Acta. 2014 Feb 27;813:70-6 [PMID: 24528662]
  55. Talanta. 2020 Nov 1;219:121310 [PMID: 32887051]
  56. Clin Exp Immunol. 2004 Apr;136(1):95-103 [PMID: 15030519]
  57. J Chromatogr A. 2020 Jan 4;1609:460450 [PMID: 31443971]
  58. J Pharm Biomed Anal. 2020 Sep 10;189:113420 [PMID: 32593849]
  59. Rapid Commun Mass Spectrom. 2019 Jul;33 Suppl 3:90-95 [PMID: 30019507]
  60. Nature. 2020 Jul;583(7816):459-468 [PMID: 32353859]
  61. Sci Rep. 2019 Dec 11;9(1):18911 [PMID: 31827124]
  62. Mol Omics. 2021 Feb 1;17(1):29-42 [PMID: 33034323]
  63. J Pharm Biomed Anal. 2020 Jan 30;178:112908 [PMID: 31610393]
  64. Pharmacol Res. 2020 Jul;157:104820 [PMID: 32360484]
  65. Anal Chem. 2008 Aug 1;80(15):5678-83 [PMID: 18671338]
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