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Research in nursing & health
08, 2024;47 (4): 369-383.

The CARING study: Examining biological, behavioral, and genetic mechanisms in the intergenerational transmission of toxic stress.

Eileen M Condon, Hannah R Scheibner, Meredith Kuzel, Mackenzie Howard, Mouhamadou Cisse, Meghan O'Connell, Yvette Conley, Sangchoon Jeon, Lois S Sadler, Nancy S Redeker
Author Information
  1. Eileen M Condon: University of Connecticut School of Nursing, Storrs, Connecticut, USA. ORCID
  2. Hannah R Scheibner: University of Connecticut School of Nursing, Storrs, Connecticut, USA.
  3. Meredith Kuzel: University of Connecticut School of Nursing, Storrs, Connecticut, USA. ORCID
  4. Mackenzie Howard: University of Connecticut School of Nursing, Storrs, Connecticut, USA.
  5. Mouhamadou Cisse: Connecticut Children's Medical Center, Hartford, Connecticut, USA.
  6. Meghan O'Connell: University of Connecticut School of Nursing, Storrs, Connecticut, USA.
  7. Yvette Conley: University of Pittsburg School of Nursing, Pittsburg, Pennsylvania, USA.
  8. Sangchoon Jeon: Yale School of Nursing, Orange, Connecticut, USA.
  9. Lois S Sadler: Yale School of Nursing, Orange, Connecticut, USA.
  10. Nancy S Redeker: University of Connecticut School of Nursing, Storrs, Connecticut, USA.
PMID: 38804202 DOI: 10.1002/nur.22400

Abstract

When children experience extreme or persistent stressors (e.g., maltreatment, housing insecurity, intimate partner violence), prolonged elevation of the stress-response system can lead to disrupted development of multiple physiological systems. This response, known as toxic stress, is associated with poor physical and mental health across the life course. Emerging evidence suggests that the effects of toxic stress may be transmitted through generations, but the biological and behavioral mechanisms that link caregivers' childhood history with the health of the children they care for remain poorly understood. The purpose of this report is to describe the research protocol for The CARING (Childhood Adversity and Resilience In the Next Generation) Study, a cross-sectional study of caregivers with children aged 3-5 years designed to (1) examine the intergenerational transmission of toxic stress and protective factors; (2) explore three hypothesized pathways of transmission: parenting, daily routines, stressors, and supports; and (3) explore the extent to which genotypic variation in candidate genes related to caregiving and stress contribute to caregivers' and children's susceptibility to the effects of early childhood experiences (i.e., gene��������environment interactions). We expect that findings from this study will provide critical data needed to identify targets for precision health interventions, reduce health disparities related to toxic stress, and prevent cycles of adversity among families at risk.

Keywords

adverse childhood experiences family family relations mother���child relations protective factors

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Grants

  1. K99 NR018876/NINR NIH HHS
  2. R00 NR018876/NINR NIH HHS
  3. R00NR018876/National Institutes of Nursing Research
  4. R00NR018876-04S/Office of Research on Women's Health

MeSH Term

Humans
Female
Cross-Sectional Studies
Male
Stress, Psychological
Child, Preschool
Caregivers
Adult
Intergenerational Relations
Adverse Childhood Experiences
Parenting
Gene-Environment Interaction
Journal Article
Article has an altmetric score of 1

Word Cloud

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