INTRODUCTION: This study was designed to investigate whether renal ��-klotho levels are associated with renal pathology. This is the first report on patients with chronic kidney disease (CKD). METHODS: We conducted a retrospective observational study. A total of 65 CKD patients were enrolled. Serum and renal biopsy samples were collected. Estimated glomerular filtration rate (eGFR) was examined by biochemical test. And ��-klotho expressions were assessed by RT-PCR and immunohistochemistry. In addition, detailed microscopic findings were reviewed. RESULTS: Renal ��-klotho levels are associated positively with eGFR, and negatively with renal pathology, including interstitial fibrosis, inflammatory cell infiltration, and tubular atrophy. CONCLUSIONS: The renal ��-klotho is related to renal pathology.
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Grants
LY15H050006/Natural Science Foundation of Zhejiang Province
20160533B62/Hangzhou Science and Technology Bureau
81803911/National Natural Science Foundation of China
