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BMC women's health
Jun 01, 2024;24 (1): 316.

Association between serum vitamin E and bacterial vaginitis in women: a cross-sectional study.

En-Hui Liu, Wan-Zhe Liao, Hao-Kai Chen, Xiao-Ye Huang, Rui-Xuan Li, Hao-Wen Liang, Xu-Guang Guo
Author Information
  1. En-Hui Liu: Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
  2. Wan-Zhe Liao: Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
  3. Hao-Kai Chen: Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
  4. Xiao-Ye Huang: Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
  5. Rui-Xuan Li: Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
  6. Hao-Wen Liang: Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
  7. Xu-Guang Guo: Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China. gysygxg@gmail.com.
PMID: 38824532 DOI: 10.1186/s12905-024-03065-4

Abstract

INTRODUCTION: Bacterial vaginitis (BV) is a common vaginal disease. vitamin E has been shown to reduce BV by enhancing immune function, but no studies have analyzed the relationship between vitamin E and BV at different BMIs and ages.
METHOD: This study used 2242 participants from four cycles of NHANES 1999-2006 in American. Participants' vitamin E levels were divided into four groups, and analyses such as study population description, stratified analysis, multiple logistic regression analysis, and curve fitting were performed. To perform data processing, the researchers used the statistical package R (The R Foundation; http://www.r-project.org ; version 3.6.3) and Empower Stats software ( www.empowerstats.net , X&Y solutions, Inc. Boston, Massachusetts).
RESULT: The concentrations of serum vitamin E were negatively correlated with the risk of BV, especially when vitamin E were at 1198-5459ug/dL with (OR���=���-0.443, 95%CI���=���0.447-0.923, P���=���0.032) or without (OR���=���-0.521, 95%CI���=���0.421-0.837, P���=���0.006) adjustment for variables. At the same time, at lower levels, there was no significant association. vitamin E supplementation may significantly reduce the risk of BV (p���<���0.001). In addition, the risk of having BV decreased and then increased with increasing vitamin E concentrations at high BMI levels (p���<���0.01).
CONCLUSION: vitamin E at moderate to high concentrations may significantly reduce BV risk, says the study, providing clinical evidence for the prevention and the treatment of BV.

Keywords

Bacterial vaginitis Cross-sectional study Female diseases National Health and Nutrition Examination Survey Vitamin E

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MeSH Term

Humans
Female
Vitamin E
Cross-Sectional Studies
Adult
Vaginosis, Bacterial
Middle Aged
Body Mass Index
Nutrition Surveys
Young Adult
United States
Risk Factors

Chemicals

Vitamin E
Journal Article

Word Cloud

Created with Highcharts 10.0.0EBVvitaminstudyVitaminriskvaginitisreducelevelsconcentrationsBacterialusedfouranalysisR3serumOR���=���-095%CI���=���0P���=���0maysignificantlyp���<���0highINTRODUCTION:commonvaginaldiseaseshownenhancingimmunefunctionstudiesanalyzedrelationshipdifferentBMIsagesMETHOD:2242participantscyclesNHANES1999-2006AmericanParticipants'dividedgroupsanalysespopulationdescriptionstratifiedmultiplelogisticregressioncurvefittingperformedperformdataprocessingresearchersstatisticalpackageFoundationhttp://wwwr-projectorgversion6EmpowerStatssoftwarewwwempowerstatsnetX&YsolutionsIncBostonMassachusettsRESULT:negativelycorrelatedespecially1198-5459ug/dL443447-0923032without521421-0837006adjustmentvariablestimelowersignificantassociationsupplementation001additiondecreasedincreasedincreasingBMI01CONCLUSION:moderatesaysprovidingclinicalevidencepreventiontreatmentAssociationbacterialwomen:cross-sectionalCross-sectionalFemalediseasesNationalHealthNutritionExaminationSurvey

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