Efficacy of omadacycline in the treatment of : a case report.

Yao Wang, Shui-Min Yi, Si-Min Huang, Wei-Xin Xu, Yi-Wen Wei, Qiang Qu, Jian Qu
Author Information
  1. Yao Wang: Department of Pharmacy, The Second Xiangya Hospital, Central South University, Institute of Clinical Pharmacy, Central South University, Changsha, China.
  2. Shui-Min Yi: Department of Pharmacy, The Second Xiangya Hospital, Central South University, Institute of Clinical Pharmacy, Central South University, Changsha, China.
  3. Si-Min Huang: Department of Pharmacy, The Second Xiangya Hospital, Central South University, Institute of Clinical Pharmacy, Central South University, Changsha, China.
  4. Wei-Xin Xu: Department of Pharmacy, The Second Xiangya Hospital, Central South University, Institute of Clinical Pharmacy, Central South University, Changsha, China.
  5. Yi-Wen Wei: Department of Pharmacy, The Second Xiangya Hospital, Central South University, Institute of Clinical Pharmacy, Central South University, Changsha, China.
  6. Qiang Qu: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
  7. Jian Qu: Department of Pharmacy, The Second Xiangya Hospital, Central South University, Institute of Clinical Pharmacy, Central South University, Changsha, China.

Abstract

, one of the main pathogens that causes community-acquired pneumonia, can lead to , a condition characterized predominantly by severe pneumonia. This disease, caused by the bacterium , can quickly progress to critical pneumonia and is often associated with damage to multiple organs. As a result, it requires close attention in terms of clinical diagnosis and treatment. Omadacycline, a new type of tetracycline derivative belonging to the aminomethylcycline class of antibiotics, is a semi-synthetic compound derived from minocycline. Its key structural feature, the aminomethyl modification, allows omadacycline to overcome bacterial resistance and broadens its range of effectiveness against bacteria. Clinical studies have demonstrated that omadacycline is not metabolized in the body, and patients with hepatic and renal dysfunction do not need to adjust their dosage. This paper reports a case of successful treatment of with omadacycline in a patient who initially did not respond to empirical treatment with moxifloxacin. The patient also experienced electrolyte disturbance, as well as dysfunction in the liver and kidneys, delirium, and other related psychiatric symptoms.

Keywords

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MeSH Term

Humans
Tetracyclines
Anti-Bacterial Agents
Legionnaires' Disease
Legionella pneumophila
Treatment Outcome
Male
Community-Acquired Infections
Moxifloxacin
Middle Aged

Chemicals

omadacycline
Tetracyclines
Anti-Bacterial Agents
Moxifloxacin

Word Cloud

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