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Aug 15, 2024;351 122783.

The rat as an animal model in chronic wound research: An update.

Mahboubeh Ghanbari, Yury Salkovskiy, Mark A Carlson
Author Information
  1. Mahboubeh Ghanbari: Department of Biomechanics, University of Nebraska at Omaha, Omaha, NE, USA. Electronic address: mghanbari@unomaha.edu.
  2. Yury Salkovskiy: Department of Biomechanics, University of Nebraska at Omaha, Omaha, NE, USA. Electronic address: ysalkovskiy@unomaha.edu.
  3. Mark A Carlson: Department of Surgery, Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: macarlson@unmc.edu.
PMID: 38848945 DOI: 10.1016/j.lfs.2024.122783

Abstract

The increasing global prevalence of chronic wounds underscores the growing importance of developing effective animal models for their study. This review offers a critical evaluation of the strengths and limitations of rat models frequently employed in chronic wound research and proposes potential improvements. It explores these models in the context of key comorbidities, including diabetes, venous and arterial insufficiency, pressure-induced blood flow obstruction, and infections. Additionally, the review examines important wound factors including age, sex, smoking, and the impact of anesthetic and analgesic drugs, acknowledging their substantial effects on research outcomes. A thorough understanding of these variables is crucial for refining animal models and can provide valuable insights for future research endeavors.

Keywords

Chronic wound Diabetic ulcer Peripheral arterial disease Pressure ulcer Rat model Venous ulcer

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Grants

  1. P20 GM109090/NIGMS NIH HHS
  2. P20 GM152301/NIGMS NIH HHS
  3. R01 HL125736/NHLBI NIH HHS

MeSH Term

Animals
Rats
Disease Models, Animal
Wound Healing
Chronic Disease
Wounds and Injuries
Humans
Journal Article Review

Word Cloud

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