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Frontiers in veterinary science
2024;11 1394055.

The use of platelet rich plasma in the treatment of degenerative joint disease in cats: an exploratory case series.

Janice Huntingford, Andrea Looney, James Johnson, Lisa Miller
Author Information
  1. Janice Huntingford: Essex Animal Hospital, Essex, ON, Canada.
  2. Andrea Looney: Central Hospital for Veterinary Medicine, North Haven, CT, United States.
  3. James Johnson: Companion Animal Health, New Castle, DE, United States.
  4. Lisa Miller: Companion Animal Health, New Castle, DE, United States.
PMID: 38863451 DOI: 10.3389/fvets.2024.1394055

Abstract

Objective: To evaluate the effectiveness of intra-articular autologous Platelet Rich Plasma (PRP) in managing Degenerative Joint Disease (DJD) in cats.
Design: Prospective pilot clinical trial.
Methods: Six domestic cats with clinically and radiographically diagnosed DJD received intra-articular injections of autologous PRP. Clinical assessments pre and post intra-articular injections were conducted using the Feline Musculoskeletal Pain Index (FMPI, owner assessed) and Visual Analog Scale (VAS, clinician assessed) at baseline, Day 14, Day 28, and Day 42-45.
Results: Significant improvements were noted in both FMPI and VAS scores at the end of the study period, indicating enhanced joint function and reduced pain.
Conclusion and clinical relevance: The study suggests the potential of PRP therapy as a safe and effective treatment for feline DJD, warranting further research with larger cohorts and longer follow-up to establish comprehensive treatment guidelines.

Keywords

degenerative joint disease (DJD) feline osteoarthritis platelet rich plasma (PRP) regenerative medicine

References

  1. Int J Mol Sci. 2019 Jul 16;20(14): [PMID: 31315202]
  2. Vet Surg. 2010 Jul;39(5):535-44 [PMID: 20561321]
  3. BMC Vet Res. 2021 Jun 5;17(1):207 [PMID: 34090433]
  4. J Orthop Surg Res. 2016 Jan 15;11:9 [PMID: 26768536]
  5. Orthop J Sports Med. 2017 Nov 13;5(11):2325967117738238 [PMID: 29164165]
  6. Tissue Eng Part B Rev. 2020 Dec;26(6):571-585 [PMID: 32380937]
  7. Thromb Haemost. 2004 Jan;91(1):4-15 [PMID: 14691563]
  8. J Cutan Aesthet Surg. 2014 Oct-Dec;7(4):189-97 [PMID: 25722595]
  9. J Am Vet Med Assoc. 2002 Mar 1;220(5):628-32 [PMID: 12418522]
  10. J Am Acad Orthop Surg. 2013 Dec;21(12):739-48 [PMID: 24292930]
  11. Implant Dent. 2001;10(4):225-8 [PMID: 11813662]
  12. Front Vet Sci. 2020 Jun 12;7:322 [PMID: 32596269]
  13. Animals (Basel). 2020 Jan 21;10(2): [PMID: 31972961]
  14. Front Vet Sci. 2016 Jan 05;2:73 [PMID: 26779493]
  15. Clin Exp Rheumatol. 2009 Mar-Apr;27(2):201-7 [PMID: 19473558]
  16. Orthop Nurs. 2011 Jul-Aug;30(4):260-3; quiz 264-5 [PMID: 21799382]
  17. Life (Basel). 2023 Dec 25;14(1): [PMID: 38255655]
  18. J Equine Vet Sci. 2020 Mar;86:102820 [PMID: 32067662]
  19. J Vet Intern Med. 2007 May-Jun;21(3):410-6 [PMID: 17552444]
  20. J Periodontal Implant Sci. 2018 Aug 31;48(4):224-235 [PMID: 30202606]
  21. Vet Surg. 2016 Aug;45(6):764-74 [PMID: 27391909]
  22. J Vet Intern Med. 2013 May-Jun;27(3):474-82 [PMID: 23551140]
  23. Front Vet Sci. 2020 Aug 11;7:512 [PMID: 32851053]
  24. Vet J. 2013 Jun;196(3):368-73 [PMID: 23369382]
  25. Osteoarthritis Cartilage. 2013 Jan;21(1):175-85 [PMID: 23041435]
  26. Am J Vet Res. 1984 Mar;45(3):518-22 [PMID: 6711980]
  27. Arthroscopy. 2012 Mar;28(3):429-39 [PMID: 22284405]
  28. BMC Vet Res. 2016 Jul 01;12(1):135 [PMID: 27369779]
  29. Am J Sports Med. 2018 Jan;46(1):171-180 [PMID: 29016185]
  30. Front Vet Sci. 2022 Apr 05;9:838481 [PMID: 35464390]
  31. Acta Orthop Traumatol Turc. 2020 Mar;54(2):186-195 [PMID: 32254035]
  32. J Feline Med Surg. 2008 Jul;10(3):235-41 [PMID: 18440263]
  33. Ann Anat. 2013 Oct;195(5):461-6 [PMID: 23722041]
  34. Biomedicines. 2023 Jul 06;11(7): [PMID: 37509560]
  35. Front Vet Sci. 2022 Feb 07;8:834546 [PMID: 35198621]
  36. Exp Cell Res. 2017 Mar 1;352(1):146-156 [PMID: 28202394]
  37. Mediators Inflamm. 2017;2017:1075975 [PMID: 28845088]
  38. J Feline Med Surg. 2017 Jul;19(7):747-757 [PMID: 28592222]
  39. PLoS One. 2015 Jul 10;10(7):e0131839 [PMID: 26162101]
  40. Vet Clin North Am Small Anim Pract. 2022 Jul;52(4):977-995 [PMID: 35562219]
  41. Exp Ther Med. 2017 Sep;14(3):1909-1918 [PMID: 28962103]
  42. Vet Surg. 2010 Jan;39(1):2-13 [PMID: 20210938]
  43. J Orthop Surg Res. 2022 Oct 8;17(1):446 [PMID: 36209223]
  44. Cell Prolif. 2009 Apr;42(2):162-70 [PMID: 19250293]
  45. Open Vet J. 2020 Aug;10(2):226-231 [PMID: 32821667]
  46. PLoS One. 2018 Mar 19;13(3):e0194752 [PMID: 29554150]
Journal Article

Word Cloud

Created with Highcharts 10.0.0PRPDJDintra-articularDayjointtreatmentautologouscatsclinicalinjectionsFMPIassessedVASstudyfelineplateletrichplasmadegenerativediseaseObjective:evaluateeffectivenessPlateletRichPlasmamanagingDegenerativeJointDiseaseDesign:ProspectivepilottrialMethods:SixdomesticclinicallyradiographicallydiagnosedreceivedClinicalassessmentsprepostconductedusingFelineMusculoskeletalPainIndexownerVisualAnalogScaleclinicianbaseline142842-45Results:SignificantimprovementsnotedscoresendperiodindicatingenhancedfunctionreducedpainConclusionrelevance:suggestspotentialtherapysafeeffectivewarrantingresearchlargercohortslongerfollow-upestablishcomprehensiveguidelinesusecats:exploratorycaseseriesosteoarthritisregenerativemedicine

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