Biosurfactant complexed with arginine has antibiofilm activity against methicillin-resistant .
Fatima Daiana Dias Barroso, Lisandra Juvêncio da Silva, Helaine Almeida Queiroz, Lívia Gurgel do Amaral Valente Sá, Anderson Ramos da Silva, Cecília Rocha da Silva, João Batista de Andrade Neto, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes, Aurora Pinazo, Lourdes Pérez, Hélio Vitoriano Nobre Júnior
Author Information
Fatima Daiana Dias Barroso: Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
Lisandra Juvêncio da Silva: Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
Helaine Almeida Queiroz: Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
Lívia Gurgel do Amaral Valente Sá: Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil. ORCID
Anderson Ramos da Silva: Department of Surfactants & Nanobiotechnology, IQAC-CSIC, Barcelona, Spain.
Cecília Rocha da Silva: Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil. ORCID
João Batista de Andrade Neto: Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil. ORCID
Bruno Coêlho Cavalcanti: Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil. ORCID
Manoel Odorico de Moraes: Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
Aurora Pinazo: Department of Surfactants & Nanobiotechnology, IQAC-CSIC, Barcelona, Spain.
Lourdes Pérez: Department of Surfactants & Nanobiotechnology, IQAC-CSIC, Barcelona, Spain.
Hélio Vitoriano Nobre Júnior: Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil. ORCID
The present study investigated the antimicrobial effectiveness of a rhamnolipid complexed with arginine (RLMIX_Arg) against planktonic cells and biofilms of methicillin-resistant (MRSA). Susceptibility testing was performed using the Clinical & Laboratory Standards Institute protocol: M07-A10, checkerboard test, biofilm in plates and catheters and flow cytometry were used. RLMIX_Arg has bactericidal and synergistic activity with oxacillin. RLMIX_Arg inhibits the formation of MRSA biofilms on plates at sub-inhibitory concentrations and has antibiofilm action against MRSA in peripheral venous catheters. Catheters impregnated with RLMIX_Arg reduce the formation of MRSA biofilms. RLMIX_Arg exhibits potential for application in preventing infections related to methicillin-resistant biofilms.
