In this article we report a case of disseminated nocardiosis caused by Nocardia otitidiscaviarum in an immunocompetent patient with chronic obstructive pulmonary disease (COPD) who complained of a cough, followed by skin and intracranial lesions. On metagenomic next-generation sequencing (mNGS) technology of respiratory samples (bronchoalveolar lavage fluid, BALF) Nocardia otitidiscaviarum was identified. The patient was treated with therapy combined with a low dose of TMP-SMX and imipenem cilastatin sodium and had a favorable outcome. The timely diagnosis of Nocardia with the help of mNGS technology and early rational treatment of TMP-SMX can help improve the prognosis.
Humans
Nocardia Infections
Nocardia
Anti-Bacterial Agents
Bronchoalveolar Lavage Fluid
Male
High-Throughput Nucleotide Sequencing
Aged
Pulmonary Disease, Chronic Obstructive
Trimethoprim, Sulfamethoxazole Drug Combination
Cilastatin, Imipenem Drug Combination
Treatment Outcome
Metagenomics
Anti-Bacterial Agents
Trimethoprim, Sulfamethoxazole Drug Combination
Cilastatin, Imipenem Drug Combination
