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Acta psychiatrica Scandinavica
Mar, 2025;151 (3): 412-425.

Sleep-wake variations of electrodermal activity in bipolar disorder.

Cl��udia Valenzuela-Pascual, Ariadna Mas, Roger Borr��s, Gerard Anmella, Miriam Sanabra, Meritxell Gonz��lez-Campos, Marc Valent��, Isabella Pacchiarotti, Antoni Benabarre, Iria Grande, Michele De Prisco, Vincenzo Oliva, Anna Bastidas, Isabel Agasi, Allan H Young, Marina Garriga, Andrea Murru, Filippo Corponi, Bryan M Li, Peter de Looff, Eduard Vieta, Diego Hidalgo-Mazzei
Author Information
  1. Cl��udia Valenzuela-Pascual: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
  2. Ariadna Mas: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
  3. Roger Borr��s: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
  4. Gerard Anmella: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
  5. Miriam Sanabra: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
  6. Meritxell Gonz��lez-Campos: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
  7. Marc Valent��: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
  8. Isabella Pacchiarotti: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
  9. Antoni Benabarre: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
  10. Iria Grande: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
  11. Michele De Prisco: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
  12. Vincenzo Oliva: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
  13. Anna Bastidas: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
  14. Isabel Agasi: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
  15. Allan H Young: Centre for Affective Disorders (CfAD), Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK. ORCID
  16. Marina Garriga: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
  17. Andrea Murru: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
  18. Filippo Corponi: School of Informatics, University of Edinburgh, Edinburgh, UK. ORCID
  19. Bryan M Li: School of Informatics, University of Edinburgh, Edinburgh, UK. ORCID
  20. Peter de Looff: Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands. ORCID
  21. Eduard Vieta: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
  22. Diego Hidalgo-Mazzei: Department of Psychiatry and Psychology, Hospital Cl��nic de Barcelona, Catalonia, Barcelona, Spain. ORCID
PMID: 38890010 DOI: 10.1111/acps.13718

Abstract

BACKGROUND: Affective states influence the sympathetic nervous system, inducing variations in electrodermal activity (EDA), however, EDA association with bipolar disorder (BD) remains uncertain in real-world settings due to confounders like physical activity and temperature. We analysed EDA separately during sleep and wakefulness due to varying confounders and potential differences in mood state discrimination capacities.
METHODS: We monitored EDA from 102 participants with BD including 35 manic, 29 depressive, 38 euthymic patients, and 38 healthy controls (HC), for 48���h. Fifteen EDA features were inferred by mixed-effect models for repeated measures considering sleep state, group and covariates.
RESULTS: Thirteen EDA feature models were significantly influenced by sleep state, notably including phasic peaks (p���<���0.001). During wakefulness, phasic peaks showed different values for mania (M [SD]���=���6.49 [5.74, 7.23]), euthymia (5.89 [4.83, 6.94]), HC (3.04 [1.65, 4.42]), and depression (3.00 [2.07, 3.92]). Four phasic features during wakefulness better discriminated between HC and mania or euthymia, and between depression and euthymia or mania, compared to sleep. Mixed symptoms, average skin temperature, and anticholinergic medication affected the models, while sex and age did not.
CONCLUSION: EDA measured from awake recordings better distinguished between BD states than sleep recordings, when controlled by confounders.

Keywords

bipolar disorder digital biomarker electrodermal activity precision psychiatry wakefulness

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Grants

  1. PI21/00340/Instituto de Salud Carlos III
  2. /Baszucki Brain Research Fund & Milken Institute
Journal Article
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Word Cloud

Created with Highcharts 10.0.0EDAsleepactivitywakefulnesselectrodermalbipolardisorderBDconfoundersstateHCmodelsphasicmaniaeuthymia3statesvariationsduetemperatureincluding38featurespeaksdepressionbetterrecordingsBACKGROUND:Affectiveinfluencesympatheticnervoussysteminducinghoweverassociationremainsuncertainreal-worldsettingslikephysicalanalysedseparatelyvaryingpotentialdifferencesmooddiscriminationcapacitiesMETHODS:monitored102participants35manic29depressiveeuthymicpatientshealthycontrols48���hFifteeninferredmixed-effectrepeatedmeasuresconsideringgroupcovariatesRESULTS:Thirteenfeaturesignificantlyinfluencednotablyp���<���0001showeddifferentvaluesM[SD]���=���649[574723]589[483694]04[165442]00[20792]FourdiscriminatedcomparedMixedsymptomsaverageskinanticholinergicmedicationaffectedsexagenotCONCLUSION:measuredawakedistinguishedcontrolledSleep-wakedigitalbiomarkerprecisionpsychiatry

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