Ozone Therapy in the Integrated Treatment of Female Dogs with Mammary Cancer: Oxidative Profile and Quality of Life.
Laís Pereira Silva, Ricardo Wagner Portela, Marília Carneiro Machado, Gisele André Baptista Canuto, João Moreira Costa-Neto, Vitor de Moraes Pina de Carvalho, Hanna Carvalho de Sá, Karine Araújo Damasceno, Vinicius Ricardo Cuña de Souza, Clarisse Simões Coelho, Alessandra Estrela-Lima
Author Information
Laís Pereira Silva: Research Center on Mammary Oncology (NPqOM), Federal University of Bahia, Salvador 40170-110, Brazil.
Ricardo Wagner Portela: Laboratory of Immunology and Molecular Biology (LABIMUNO), Institute of Health Sciences, Federal University of Bahia, Salvador 40110-100, Brazil. ORCID
Marília Carneiro Machado: Research Center on Mammary Oncology (NPqOM), Federal University of Bahia, Salvador 40170-110, Brazil.
Gisele André Baptista Canuto: Department of Analytical Chemistry, Institute of Chemistry, Federal University of Bahia, Salvador 40170-110, Brazil. ORCID
João Moreira Costa-Neto: Research Center on Mammary Oncology (NPqOM), Federal University of Bahia, Salvador 40170-110, Brazil. ORCID
Vitor de Moraes Pina de Carvalho: Research Center on Mammary Oncology (NPqOM), Federal University of Bahia, Salvador 40170-110, Brazil. ORCID
Hanna Carvalho de Sá: Department of Analytical Chemistry, Institute of Chemistry, Federal University of Bahia, Salvador 40170-110, Brazil.
Karine Araújo Damasceno: Research Center on Mammary Oncology (NPqOM), Federal University of Bahia, Salvador 40170-110, Brazil.
Vinicius Ricardo Cuña de Souza: Faculty of Veterinary Medicine, Lusofona University, 1749-024 Lisbon, Portugal. ORCID
Considering the high frequency of malignant breast tumors, there is a growing search for new therapeutic strategies that control neoplastic growth and dissemination, combined with fewer adverse reactions. Therefore, this study evaluated the effects of ozone therapy in female dogs with mammary cancer undergoing chemotherapy treatment. Twenty-five canines diagnosed with malignant mammary neoplasia were divided into two groups: one treated with carboplatin alone ( = 11) and the other with carboplatin associated with ozone therapy ( = 14). Clinical and laboratory evaluations, mastectomy, analysis of the oxidative profile based on total antioxidant capacity (TAC) and serum concentrations of malondialdehyde (MDA), survival rate, and quality of life were performed. Animals in the ozone therapy group had higher concentrations of red blood cells and platelets, significantly improving the survival rate and quality of life. Furthermore, adverse reactions were less intense and frequent in this group, which was associated with an increase in TAC and a reduction in MDA. These results indicate that the combination of carboplatin and ozone therapy represents a promising complementary treatment for female dogs with mammary cancer, as it was associated with fewer adverse reactions and a better oxidative profile.
