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2024;12 e17615.

The effects of exercise on FGF21 in adults: a systematic review and meta-analysis.

Chuannan Liu, Xujie Yan, Yue Zong, Yanan He, Guan Yang, Yue Xiao, Songtao Wang
Author Information
  1. Chuannan Liu: School of Physical Education and Sports Science, South China Normal University, Guangzhou, China.
  2. Xujie Yan: School of Physical Education and Sports Science, South China Normal University, Guangzhou, China.
  3. Yue Zong: School of Physical Education and Sports Science, South China Normal University, Guangzhou, China.
  4. Yanan He: School of Physical Education and Sports Science, South China Normal University, Guangzhou, China.
  5. Guan Yang: School of Physical Education, South China University of Technology, Guangzhou, China.
  6. Yue Xiao: School of Physical Education and Sports Science, South China Normal University, Guangzhou, China.
  7. Songtao Wang: School of Physical Education and Sports Science, South China Normal University, Guangzhou, China.
PMID: 38948228 DOI: 10.7717/peerj.17615

Abstract

Background: Fibroblast growth factor 21 (FGF21) is a key hormone factor that regulates glucose and lipid homeostasis. Exercise may regulate its effects and affect disease states. Therefore, we sought to determine how exercise affects FGF21 concentrations in adults.
Methods: The review was registered in the International Prospective Systematic Review (PROSPERO, CRD42023471163). The Cochrane Library, PubMed, and Web of Science databases were searched for studies through July 2023. Studies that assessed the effects of exercise training on FGF21 concentration in adults were included. The random effect model, data with standardized mean difference (SMD), and 95% confidence intervals (CI) were used to evaluate the pooled effect size of exercise training on FGF21. The risk of heterogeneity and bias were evaluated. A total of 12 studies involving 401 participants were included.
Results: The total effect size was 0.3 (95% CI [-0.3-0.89], = 0.33) when comparing participants who exercised to those who were sedentary. However, subgroup analysis indicated that concurrent exercise and a duration ≥10 weeks significantly decreased FGF21 concentrations with an effect size of -0.38 (95% CI [-0.74--0.01], < 0.05) and -0.38 (95% CI [-0.63--0.13], < 0.01), respectively.
Conclusion: Concurrent exercise and longer duration may be more efficient way to decrease FGF21 concentrations in adults with metabolic disorder.

Keywords

Exercise training FGF-21 Meta-analysis Metabolic disorder adults

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MeSH Term

Fibroblast Growth Factors
Humans
Exercise
Adult

Chemicals

Fibroblast Growth Factors
FGF21 protein, human
fibroblast growth factor 21
Journal Article Systematic Review Meta-Analysis
Article has an altmetric score of 1

Word Cloud

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