OpenLB
Open Library of Bioscience
Advanced Search
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Sep, 2024;11 (36): e2400595.

Revolutionary Point-of-Care Wearable Diagnostics for Early Disease Detection and Biomarker Discovery through Intelligent Technologies.

Fatemeh Haghayegh, Alireza Norouziazad, Elnaz Haghani, Ariel Avraham Feygin, Reza Hamed Rahimi, Hamidreza Akbari Ghavamabadi, Deniz Sadighbayan, Faress Madhoun, Manos Papagelis, Tina Felfeli, Razieh Salahandish
Author Information
  1. Fatemeh Haghayegh: Laboratory of Advanced Biotechnologies for Health Assessments (Lab-HA), Biomedical Engineering Program, Lassonde School of Engineering, York University, Toronto, M3J 1P3, Canada.
  2. Alireza Norouziazad: Laboratory of Advanced Biotechnologies for Health Assessments (Lab-HA), Biomedical Engineering Program, Lassonde School of Engineering, York University, Toronto, M3J 1P3, Canada.
  3. Elnaz Haghani: Laboratory of Advanced Biotechnologies for Health Assessments (Lab-HA), Biomedical Engineering Program, Lassonde School of Engineering, York University, Toronto, M3J 1P3, Canada.
  4. Ariel Avraham Feygin: Laboratory of Advanced Biotechnologies for Health Assessments (Lab-HA), Biomedical Engineering Program, Lassonde School of Engineering, York University, Toronto, M3J 1P3, Canada.
  5. Reza Hamed Rahimi: Laboratory of Advanced Biotechnologies for Health Assessments (Lab-HA), Biomedical Engineering Program, Lassonde School of Engineering, York University, Toronto, M3J 1P3, Canada.
  6. Hamidreza Akbari Ghavamabadi: Laboratory of Advanced Biotechnologies for Health Assessments (Lab-HA), Biomedical Engineering Program, Lassonde School of Engineering, York University, Toronto, M3J 1P3, Canada.
  7. Deniz Sadighbayan: Department of Biology, Faculty of Science, York University, Toronto, ON, M3J 1P3, Canada.
  8. Faress Madhoun: Laboratory of Advanced Biotechnologies for Health Assessments (Lab-HA), Biomedical Engineering Program, Lassonde School of Engineering, York University, Toronto, M3J 1P3, Canada.
  9. Manos Papagelis: Department of Electrical Engineering and Computer Science (EECS), Lassonde School of Engineering, York University, Toronto, ON, M3J 1P3, Canada.
  10. Tina Felfeli: Department of Ophthalmology and Vision Sciences, University of Toronto, Ontario, M5T 3A9, Canada.
  11. Razieh Salahandish: Laboratory of Advanced Biotechnologies for Health Assessments (Lab-HA), Biomedical Engineering Program, Lassonde School of Engineering, York University, Toronto, M3J 1P3, Canada. ORCID
PMID: 38958517 DOI: 10.1002/advs.202400595

Abstract

Early-stage disease detection, particularly in Point-Of-Care (POC) wearable formats, assumes pivotal role in advancing healthcare services and precision-medicine. Public benefits of early detection extend beyond cost-effectively promoting healthcare outcomes, to also include reducing the risk of comorbid diseases. Technological advancements enabling POC biomarker recognition empower discovery of new markers for various health conditions. Integration of POC wearables for biomarker detection with intelligent frameworks represents ground-breaking innovations enabling automation of operations, conducting advanced large-scale data analysis, generating predictive models, and facilitating remote and guided clinical decision-making. These advancements substantially alleviate socioeconomic burdens, creating a paradigm shift in diagnostics, and revolutionizing medical assessments and technology development. This review explores critical topics and recent progress in development of 1) POC systems and wearable solutions for early disease detection and physiological monitoring, as well as 2) discussing current trends in adoption of smart technologies within clinical settings and in developing biological assays, and ultimately 3) exploring utilities of POC systems and smart platforms for biomarker discovery. Additionally, the review explores technology translation from research labs to broader applications. It also addresses associated risks, biases, and challenges of widespread Artificial Intelligence (AI) integration in diagnostics systems, while systematically outlining potential prospects, current challenges, and opportunities.

Keywords

AI���assisted biomarker discovery high���throughput omics and clinical study intelligent diagnostics point���of���care biomarker detection platforms precision medicine remote disease detection wearable health monitoring

References

  1. Transl Oncol. 2021 Jan;14(1):100907 [PMID: 33217646]
  2. Sens Actuators B Chem. 2021 Apr 1;332: [PMID: 33542590]
  3. Nat Commun. 2021 Sep 24;12(1):5645 [PMID: 34561440]
  4. Sci Rep. 2021 Feb 25;11(1):4673 [PMID: 33633145]
  5. Sci Rep. 2017 Mar 20;7:44778 [PMID: 28317856]
  6. Microsyst Nanoeng. 2023 Jan 1;9:3 [PMID: 36597510]
  7. ACS Appl Bio Mater. 2020 Nov 16;3(11):7306-7325 [PMID: 35019473]
  8. Adv Sci (Weinh). 2022 Jan;9(1):e2103257 [PMID: 34713981]
  9. Alzheimers Res Ther. 2022 Jan 10;14(1):7 [PMID: 35012639]
  10. Biomedicines. 2020 Nov 30;8(12): [PMID: 33265898]
  11. PLoS Comput Biol. 2021 Nov 18;17(11):e1009477 [PMID: 34793435]
  12. Front Med (Lausanne). 2021 Sep 22;8:747333 [PMID: 34631760]
  13. Anal Chem. 2022 Aug 23;94(33):11619-11626 [PMID: 35943181]
  14. Front Med (Lausanne). 2021 Jul 01;8:662340 [PMID: 34277655]
  15. Biosens Bioelectron. 2020 Apr 1;153:112038 [PMID: 31989942]
  16. Sens Actuators B Chem. 2019 Oct 1;296: [PMID: 32831479]
  17. Nat Mach Intell. 2023 Apr;5(4):351-362 [PMID: 37693852]
  18. Sens Actuators B Chem. 2019 Jul 1;290:118-124 [PMID: 31777430]
  19. Adv Healthc Mater. 2019 Dec;8(24):e1901321 [PMID: 31714014]
  20. ACS Sens. 2020 Nov 25;5(11):3346-3364 [PMID: 33185417]
  21. Nat Biotechnol. 2019 Apr;37(4):389-406 [PMID: 30804534]
  22. Talanta. 2022 Nov 1;249:123695 [PMID: 35728453]
  23. Sci Rep. 2021 Feb 23;11(1):4388 [PMID: 33623096]
  24. Front Genet. 2020 Feb 05;11:19 [PMID: 32117438]
  25. Ann Lab Med. 2023 Sep 1;43(5):401-407 [PMID: 37080740]
  26. Anal Chem. 2019 May 21;91(10):6569-6576 [PMID: 31006229]
  27. Circulation. 2000 Jun 13;101(23):E215-20 [PMID: 10851218]
  28. ACS Nano. 2018 Jan 23;12(1):63-73 [PMID: 29303554]
  29. Phys Eng Sci Med. 2020 Jun;43(2):635-640 [PMID: 32524445]
  30. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4834-4842 [PMID: 30782834]
  31. Annu Rev Anal Chem (Palo Alto Calif). 2013;6:119-41 [PMID: 23495732]
  32. Biosens Bioelectron. 2019 Jul 1;136:60-75 [PMID: 31035028]
  33. Biosens Bioelectron. 2020 Mar 15;152:112015 [PMID: 32056735]
  34. Clin Lab Med. 2023 Mar;43(1):99-114 [PMID: 36764811]
  35. ACS Nano. 2022 Feb 22;16(2):2629-2639 [PMID: 35040314]
  36. Clin Epigenetics. 2020 Jul 6;12(1):100 [PMID: 32631437]
  37. Anal Chem. 2022 Oct 18;94(41):14331-14339 [PMID: 36190245]
  38. Int J Mol Sci. 2012;13(1):427-52 [PMID: 22312262]
  39. ACS Omega. 2021 Dec 02;6(49):33837-33845 [PMID: 34926930]
  40. Anal Chem. 2023 May 2;95(17):6940-6947 [PMID: 37083348]
  41. Sci Rep. 2020 Sep 16;10(1):15200 [PMID: 32938996]
  42. Adv Sci (Weinh). 2023 Nov;10(31):e2303234 [PMID: 37740417]
  43. Clin Chim Acta. 2019 Jun;493:138-147 [PMID: 30853460]
  44. Eur J Health Law. 2021 Sep 14;28(4):341-358 [PMID: 34610575]
  45. J Inflamm Res. 2021 May 14;14:1933-1943 [PMID: 34017190]
  46. Nat Med. 2022 Jan;28(1):31-38 [PMID: 35058619]
  47. Nat Rev Chem. 2022 Dec;6(12):899-915 [PMID: 37117704]
  48. Adv Sci (Weinh). 2022 May;9(16):e2201059 [PMID: 35362243]
  49. JMIR Med Inform. 2022 Feb 15;10(2):e33063 [PMID: 35166679]
  50. Nat Commun. 2023 Aug 21;14(1):5080 [PMID: 37604821]
  51. J Transl Med. 2022 Mar 26;20(1):143 [PMID: 35346252]
  52. Biosens Bioelectron. 2022 Aug 15;210:114351 [PMID: 35569269]
  53. Sci Rep. 2022 Jan 10;12(1):328 [PMID: 35013370]
  54. Int J Pharm. 2018 Aug 25;547(1-2):244-249 [PMID: 29879505]
  55. Adv Mater. 2023 Aug;35(34):e2107986 [PMID: 35332957]
  56. Sensors (Basel). 2022 Dec 15;22(24): [PMID: 36560227]
  57. Biomark Res. 2023 Mar 29;11(1):35 [PMID: 36991494]
  58. Nature. 2003 Mar 13;422(6928):198-207 [PMID: 12634793]
  59. Nat Commun. 2021 Jan 27;12(1):634 [PMID: 33504775]
  60. Transl Psychiatry. 2022 Sep 8;12(1):372 [PMID: 36075922]
  61. Proteomics. 2023 Apr;23(7-8):e2200031 [PMID: 36086888]
  62. J Biol Eng. 2019 Feb 19;13:16 [PMID: 30828380]
  63. ACS Appl Bio Mater. 2022 May 16;5(5):2046-2068 [PMID: 35473316]
  64. Sensors (Basel). 2022 Feb 04;22(3): [PMID: 35161928]
  65. ACS Sens. 2019 Apr 26;4(4):1048-1054 [PMID: 30860365]
  66. Adv Drug Deliv Rev. 2021 Sep;176:113844 [PMID: 34182017]
  67. Expert Opin Drug Discov. 2014 Jan;9(1):93-104 [PMID: 24304044]
  68. Lab Chip. 2022 Apr 12;22(8):1542-1555 [PMID: 35297932]
  69. Sci Rep. 2021 Jan 21;11(1):1986 [PMID: 33479284]
  70. RSC Adv. 2023 Jan 5;13(2):1301-1311 [PMID: 36686949]
  71. Adv Sci (Weinh). 2023 Sep;10(27):e2301930 [PMID: 37485618]
  72. Cancers (Basel). 2023 Apr 30;15(9): [PMID: 37174039]
  73. Biosens Bioelectron. 2022 Sep 15;212:114429 [PMID: 35671693]
  74. Biosens Bioelectron. 2022 Oct 1;213:114459 [PMID: 35728365]
  75. Digit Biomark. 2017 Aug 17;1(1):73-81 [PMID: 32095747]
  76. Adv Mater. 2019 Nov;31(45):e1805033 [PMID: 30345586]
  77. Nat Commun. 2021 May 26;12(1):3168 [PMID: 34039967]
  78. Analyst. 2018 Mar 12;143(6):1326-1348 [PMID: 29469148]
  79. Anal Chim Acta. 2022 May 22;1208:339843 [PMID: 35525593]
  80. Biosens Bioelectron. 2022 Feb 1;197:113761 [PMID: 34800926]
  81. Sci Adv. 2017 Mar 22;3(3):e1501645 [PMID: 28345028]
  82. Curr Protoc. 2023 Jun;3(6):e801 [PMID: 37358238]
  83. Anal Bioanal Chem. 2022 Jan;414(2):759-789 [PMID: 34432105]
  84. PLoS One. 2024 Mar 8;19(3):e0299516 [PMID: 38457401]
  85. Lancet Digit Health. 2023 Sep;5(9):e618-e626 [PMID: 37625896]
  86. Nat Rev Cardiol. 2021 Jul;18(7):465-478 [PMID: 33526938]
  87. Oncology. 2020;98(12):889-892 [PMID: 32882692]
  88. J Clin Virol. 2017 Dec;97:22-25 [PMID: 29096389]
  89. Eye Vis (Lond). 2023 Apr 1;10(1):14 [PMID: 37004107]
  90. J Lab Autom. 2013 Oct;18(5):350-66 [PMID: 23757343]
  91. J Clin Virol Plus. 2021 Sep;1(3):100030 [PMID: 35262016]
  92. Chem Soc Rev. 2020 Mar 21;49(6):1812-1866 [PMID: 32100760]
  93. Adv Sci (Weinh). 2022 Apr;9(12):e2104738 [PMID: 35195359]
  94. Brain Sci. 2021 Nov 16;11(11): [PMID: 34827518]
  95. Nat Biotechnol. 2020 Feb;38(2):217-224 [PMID: 31768044]
  96. NPJ Digit Med. 2019;2: [PMID: 31119199]
  97. Bioanalysis. 2020 Oct;12(20):1469-1481 [PMID: 33006485]
  98. Trends Pharmacol Sci. 2023 Jul;44(7):411-424 [PMID: 37268540]
  99. Sci Rep. 2018 Oct 26;8(1):15890 [PMID: 30367078]
  100. Front Microbiol. 2023 Sep 07;14:1243987 [PMID: 37744906]
  101. J Neuropathol Exp Neurol. 2012 Dec;71(12):1075-85 [PMID: 23147505]
  102. Nanoscale. 2023 Aug 17;15(32):13466-13472 [PMID: 37548371]
  103. Respir Res. 2017 Jun 13;18(1):117 [PMID: 28610627]
  104. Nat Commun. 2022 Jul 26;13(1):4057 [PMID: 35882841]
  105. RSC Adv. 2023 Aug 8;13(34):23788-23795 [PMID: 37560618]
  106. Diagnostics (Basel). 2021 Jan 01;11(1): [PMID: 33401392]
  107. Genome Med. 2019 Nov 19;11(1):70 [PMID: 31744524]
  108. Lancet Glob Health. 2022 Sep;10(9):e1336-e1346 [PMID: 35878625]
  109. Sensors (Basel). 2019 Nov 08;19(22): [PMID: 31717442]
  110. Mol Neurodegener. 2021 Aug 12;16(1):55 [PMID: 34384464]
  111. Biosens Bioelectron. 2022 May 1;203:114018 [PMID: 35114466]
  112. Anal Bioanal Chem. 2021 Oct;413(24):6037-6057 [PMID: 34389877]
  113. Nat Biomed Eng. 2022 Nov;6(11):1214-1224 [PMID: 35534575]
  114. BMC Med Genomics. 2020 Nov 23;13(1):178 [PMID: 33228632]
  115. Lab Chip. 2020 Jun 21;20(12):2122-2135 [PMID: 32391827]
  116. Cancer Biomark. 2022;33(2):173-184 [PMID: 35213360]
  117. Brief Bioinform. 2011 Nov;12(6):714-22 [PMID: 21242203]
  118. Anal Chem. 2020 Jul 21;92(14):10153-10161 [PMID: 32588617]
  119. Sci Adv. 2021 May 21;7(21): [PMID: 34020961]
  120. Talanta. 2021 Apr 1;225:122002 [PMID: 33592810]
  121. Open Heart. 2019 May 13;6(1):e000955 [PMID: 31217993]
  122. Bioengineering (Basel). 2023 Apr 20;10(4): [PMID: 37106679]
  123. Cogn Neurodyn. 2023 Jun;17(3):647-659 [PMID: 37265658]
  124. Analyst. 2021 Feb 7;146(3):889-895 [PMID: 33237051]
  125. Adv Sci (Weinh). 2023 Mar;10(7):e2204171 [PMID: 36461733]
  126. ACS Appl Mater Interfaces. 2022 Mar 16;14(10):12630-12639 [PMID: 35230095]
  127. Sci Adv. 2020 Apr 24;6(17):eaba3252 [PMID: 32426469]
  128. Sci Rep. 2016 Jun 02;6:25696 [PMID: 27254731]
  129. Pharmaceutics. 2023 May 31;15(6): [PMID: 37376078]
  130. J Am Coll Cardiol. 2019 May 7;73(17):2195-2205 [PMID: 31047008]
  131. Adv Sci (Weinh). 2020 Aug 28;7(20):2001116 [PMID: 33101851]
  132. Lab Chip. 2021 Dec 21;22(1):108-120 [PMID: 34860233]
  133. Anal Chem. 2022 Feb 22;94(7):3418-3426 [PMID: 35148076]
  134. Sci Adv. 2022 Mar 25;8(12):eabn1736 [PMID: 35319971]
  135. Lab Chip. 2022 Dec 6;22(24):4860-4870 [PMID: 36377409]
  136. Clin Lab Med. 2024 Mar;44(1):23-32 [PMID: 38280795]
  137. Nat Med. 2022 Jun;28(6):1131-1132 [PMID: 35710988]
  138. Regul Toxicol Pharmacol. 2018 Apr;94:8-15 [PMID: 29337192]
  139. Med Phys. 2018 Apr;45(4):e40-e52 [PMID: 29405298]
  140. PLoS One. 2020 Apr 24;15(4):e0232391 [PMID: 32330208]
  141. Metabolites. 2020 Jan 26;10(2): [PMID: 31991929]
  142. Anal Chem. 2023 Apr 4;95(13):5542-5552 [PMID: 36944135]
  143. Anal Bioanal Chem. 2011 Jul;401(1):17-27 [PMID: 21541816]
  144. Front Med Technol. 2023 Feb 20;5:1101476 [PMID: 36891483]
  145. Anal Chem. 2023 Mar 14;95(10):4605-4611 [PMID: 36859794]
  146. Biosensors (Basel). 2023 Jan 29;13(2): [PMID: 36831968]
  147. ACS Infect Dis. 2017 Oct 13;3(10):767-776 [PMID: 28875696]
  148. PeerJ. 2014 Aug 14;2:e524 [PMID: 25165633]
  149. Front Bioinform. 2023 Jul 14;3:1228989 [PMID: 37521315]
  150. J Ren Care. 2024 Jun;50(2):104-111 [PMID: 36786046]
  151. Lab Chip. 2019 Feb 12;19(4):674-681 [PMID: 30657509]
  152. ACS Nano. 2021 Mar 23;15(3):4054-4065 [PMID: 33296173]
  153. Metabolites. 2020 May 29;10(6): [PMID: 32485899]
  154. Sci Adv. 2021 Jan 22;7(4): [PMID: 33523953]
  155. Anal Chem. 2023 Feb 14;95(6):3434-3441 [PMID: 36719948]
  156. NPJ Precis Oncol. 2021 Jun 18;5(1):54 [PMID: 34145374]
  157. Talanta. 2016 May 15;152:269-76 [PMID: 26992520]
  158. Nat Biomed Eng. 2022 Jan;6(1):76-93 [PMID: 34992270]
  159. Bioengineering (Basel). 2023 Oct 18;10(10): [PMID: 37892946]
  160. Circulation. 2017 Nov 7;136(19):1784-1794 [PMID: 28851729]
  161. J Pathol. 2019 Oct;249(2):143-150 [PMID: 31144302]
  162. Cancer Rep (Hoboken). 2023 Feb;6(2):e1764 [PMID: 36607830]
  163. Mod Pathol. 2022 Dec;35(12):1791-1803 [PMID: 36198869]
  164. J Am Coll Cardiol. 2022 Aug 9;80(6):613-626 [PMID: 35926935]
  165. Clin Biochem. 2022 May;103:1-7 [PMID: 35227670]
  166. Langmuir. 2023 Mar 7;39(9):3420-3430 [PMID: 36880227]
  167. Cell Tissue Res. 2023 Oct;394(1):17-31 [PMID: 37498390]
  168. Talanta. 2022 May 1;241:123187 [PMID: 35030501]
  169. Anal Chem. 2022 Jun 21;94(24):8659-8667 [PMID: 35656772]
  170. Comput Biol Med. 2021 Dec;139:104947 [PMID: 34678481]
  171. J Anal Test. 2022;6(3):247-273 [PMID: 35039787]
  172. ACS Sens. 2023 May 26;8(5):1989-1999 [PMID: 37129234]
  173. EBioMedicine. 2022 May;79:104001 [PMID: 35439677]
  174. Malar J. 2022 Apr 12;21(1):122 [PMID: 35413904]
  175. Adv Sci (Weinh). 2018 Aug 02;5(10):1800880 [PMID: 30356971]
  176. Comput Biol Med. 2022 Apr;143:105296 [PMID: 35149458]
  177. Bol Med Hosp Infant Mex. 2017 May - Jun;74(3):219-226 [PMID: 29382490]
  178. BMJ Health Care Inform. 2024 Apr 08;31(1): [PMID: 38589213]
  179. ACS Sens. 2020 Jun 26;5(6):1689-1698 [PMID: 32466640]
  180. ACS Nano. 2023 Jul 25;17(14):13700-13714 [PMID: 37458511]
  181. Lab Chip. 2022 Aug 9;22(16):2925-2937 [PMID: 35904162]
  182. Curr Opin Electrochem. 2020 Oct;23:174-184 [PMID: 32984642]
  183. Nat Biomed Eng. 2023 Oct;7(10):1293-1306 [PMID: 37349389]
  184. Epilepsia. 2021 Mar;62 Suppl 2:S116-S124 [PMID: 32712958]
  185. Small. 2024 Feb;20(6):e2305110 [PMID: 37752776]
  186. Sci Rep. 2022 May 19;12(1):8360 [PMID: 35589837]
  187. Pac Symp Biocomput. 2021;26:232-243 [PMID: 33691020]
  188. Nat Med. 2021 Jan;27(1):73-77 [PMID: 33122860]
  189. Anal Chem. 2023 May 16;95(19):7552-7559 [PMID: 37139959]
  190. Exp Biol Med (Maywood). 2018 Feb;243(3):213-221 [PMID: 29405771]
  191. Arch Oral Biol. 2018 Mar;87:15-34 [PMID: 29247855]
  192. Clin Oral Investig. 2023 Oct;27(10):5719-5736 [PMID: 37698630]
  193. Adv Sci (Weinh). 2024 Sep;11(36):e2400595 [PMID: 38958517]
  194. Adv Sci (Weinh). 2021 Oct;8(19):e2100640 [PMID: 34363354]
  195. Adv Sci (Weinh). 2020 Jan 10;7(6):1902673 [PMID: 32195091]
  196. Small. 2023 May;19(20):e2207381 [PMID: 36799198]
  197. ACS Appl Mater Interfaces. 2020 Jul 29;12(30):34337-34361 [PMID: 32579332]
  198. Adv Sci (Weinh). 2023 Nov;10(31):e2303285 [PMID: 37587020]
  199. N Engl J Med. 2020 Dec 17;383(25):2477-2478 [PMID: 33326721]
  200. Talanta. 2022 Nov 1;249:123375 [PMID: 35738204]
  201. Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22727-22735 [PMID: 32868442]
  202. Neuroimage. 2006 Apr 1;30(2):400-16 [PMID: 16360320]
  203. Nano Lett. 2023 Jan 11;23(1):98-106 [PMID: 36573824]
  204. Nature. 2022 May;605(7910):464-469 [PMID: 35585345]
  205. Int J Nanomedicine. 2021 Jan 14;16:383-402 [PMID: 33488077]
  206. ACS Sens. 2021 Jul 23;6(7):2763-2771 [PMID: 34228919]
  207. Sci Rep. 2017 May 25;7(1):2427 [PMID: 28546534]
  208. Trends Analyt Chem. 2021 Apr;137:116205 [PMID: 33531721]
  209. Biomed Opt Express. 2021 Mar 22;12(4):2204-2220 [PMID: 33996224]
  210. Analyst. 2021 Apr 21;146(8):2449-2462 [PMID: 33899053]
  211. Semin Radiat Oncol. 2019 Oct;29(4):354-361 [PMID: 31472738]
  212. Am J Law Med. 2021 Dec;47(4):427-454 [PMID: 35297753]
  213. Sci Adv. 2023 May 3;9(18):eadg4272 [PMID: 37134158]
  214. Adv Sci (Weinh). 2019 Jul 02;6(16):1900925 [PMID: 31453071]
  215. Trends Mol Med. 2023 Sep;29(9):765-776 [PMID: 37474378]
  216. Adv Mater. 2022 Mar;34(10):e2108607 [PMID: 34918409]
  217. Biomed Pharmacother. 2022 Sep;153:113538 [PMID: 36076617]
  218. J Lipid Atheroscler. 2021 Sep;10(3):282-290 [PMID: 34621699]
  219. Diagnostics (Basel). 2023 Aug 16;13(16): [PMID: 37627951]
  220. Biosens Bioelectron. 2023 Oct 15;238:115582 [PMID: 37572409]
  221. CA Cancer J Clin. 2021 Jul;71(4):333-358 [PMID: 33982817]
  222. Front Endocrinol (Lausanne). 2022 Oct 27;13:1037164 [PMID: 36387907]
  223. Front Cell Infect Microbiol. 2022 Jul 06;12:882855 [PMID: 35873146]
  224. Anal Chem. 2023 Oct 24;95(42):15690-15699 [PMID: 37830461]
  225. Sci Transl Med. 2016 Nov 23;8(366):366ra165 [PMID: 27881826]
  226. Nat Med. 2021 Dec;27(12):2176-2182 [PMID: 34893776]
  227. Comput Methods Programs Biomed. 2019 Oct;179:104992 [PMID: 31443858]
  228. Adv Sci (Weinh). 2022 Jan;9(2):e2103331 [PMID: 34747140]
  229. J Invest Dermatol. 2019 Oct;139(10):2068-2074.e1 [PMID: 31543209]
  230. NPJ Digit Med. 2022 Mar 25;5(1):36 [PMID: 35338234]
  231. Small. 2023 Dec;19(51):e2207658 [PMID: 37046181]
  232. Adv Sci (Weinh). 2022 Oct;9(28):e2203597 [PMID: 35975449]
  233. Sensors (Basel). 2019 Oct 18;19(20): [PMID: 31635378]
  234. Proteomes. 2023 Jan 10;11(1): [PMID: 36648960]
  235. J Med Internet Res. 2023 Jan 19;25:e42672 [PMID: 36656625]
  236. Cytometry A. 2021 Dec;99(12):1176-1186 [PMID: 34089228]
  237. Analyst. 2017 Mar 13;142(6):858-882 [PMID: 28217778]

Grants

  1. /York University
  2. /Lassonde Innovation Fund
  3. RGPIN-2023-05091/Natural Sciences and Engineering Research Council of Canada

MeSH Term

Humans
Wearable Electronic Devices
Biomarkers
Point-of-Care Systems
Early Diagnosis
Artificial Intelligence
Monitoring, Physiologic

Chemicals

Biomarkers
Journal Article Review
Article has an altmetric score of 11

Word Cloud

Created with Highcharts 10.0.0detectionPOCbiomarkerdiseasewearablediscoveryclinicaldiagnosticssystemshealthcareearlyalsoadvancementsenablinghealthintelligentremotetechnologydevelopmentreviewexploresmonitoringcurrentsmartplatformschallengesEarly-stageparticularlyPoint-Of-Careformatsassumespivotalroleadvancingservicesprecision-medicinePublicbenefitsextendbeyondcost-effectivelypromotingoutcomesincludereducingriskcomorbiddiseasesTechnologicalrecognitionempowernewmarkersvariousconditionsIntegrationwearablesframeworksrepresentsground-breakinginnovationsautomationoperationsconductingadvancedlarge-scaledataanalysisgeneratingpredictivemodelsfacilitatingguideddecision-makingsubstantiallyalleviatesocioeconomicburdenscreatingparadigmshiftrevolutionizingmedicalassessmentscriticaltopicsrecentprogress1solutionsphysiologicalwell2discussingtrendsadoptiontechnologieswithinsettingsdevelopingbiologicalassaysultimately3exploringutilitiesAdditionallytranslation fromresearchlabsbroaderapplicationsaddressesassociatedrisksbiaseswidespreadArtificialIntelligenceAIintegrationsystematicallyoutliningpotentialprospectsopportunitiesRevolutionaryPoint-of-CareWearableDiagnosticsEarlyDiseaseDetectionBiomarkerDiscoveryIntelligentTechnologiesAI���assistedhigh���throughputomicsstudypoint���of���careprecisionmedicine

Similar Articles

Cited By