Modification of a Carboxymethyl Cellulose/Poly(vinyl alcohol) Hydrogel Film with Citric Acid and Glutaraldehyde Crosslink Agents to Enhance the Anti-Inflammatory Effectiveness of Triamcinolone Acetonide in Wound Healing.
Kanticha Pratinthong: Division of Packaging Technology, School of Agro-Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand.
Winita Punyodom: Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
Pensak Jantrawut: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Muang, Chiang Mai 50200, Thailand. ORCID
Kittisak Jantanasakulwong: Division of Packaging Technology, School of Agro-Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand.
Wirongrong Tongdeesoontorn: School of Agro-Industry, Mae Fah Luang University, 333 Moo 1 Tasud, Chiang Rai 57100, Thailand. ORCID
Montira Sriyai: Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand. ORCID
Rangsan Panyathip: Division of Packaging Technology, School of Agro-Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand. ORCID
Sarinthip Thanakkasaranee: Division of Packaging Technology, School of Agro-Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand. ORCID
Patnarin Worajittiphon: Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand. ORCID
Nuttapol Tanadchangsaeng: College of Biomedical Engineering, Rangsit University, Pathumthani 12000, Thailand. ORCID
Pornchai Rachtanapun: Division of Packaging Technology, School of Agro-Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand. ORCID
Anti-inflammatory wound healing involves targeted drug delivery to the wound site using hydrogel materials to prolong drug effectiveness. In this work, hydrogel films were fabricated using carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) crosslinked with citric acid (CA) and glutaraldehyde (GA) at different concentrations. The crosslinker densities were optimized with various CA (2-10% /) and GA (1-5% /) concentrations. The optimized crosslink densities in the hydrogel exhibited additional functional group peaks in the FT-IR spectra at 1740 cm for the C=O stretching of the ester linkage in CA and at 1060 cm for the C-O-C stretching of the ether group in GA. Significantly, the internal porous structures of hydrogel composite films improved density, swelling capacities, solubility percentage reduction, and decreased water retention capacities with optimized crosslinker densities. Therefore, these hydrogel composite films were utilized as drug carriers for controlled drug release within 24 h during medical treatment. Moreover, the hydrogel films demonstrated increased triamcinolone acetonide (TAA) absorption with higher crosslinker density, resulting in delayed drug release and improved TAA efficiency in anti-inflammatory activity. As a result, the modified hydrogel showed the capability of being an alternative material with enhanced anti-inflammatory efficiency with hydrogel films.
