Disparate trajectories of cognitive aging among American Indian and Alaskan Native people with and without HIV.
Micah J Savin, Desiree Byrd, Lucette Cysique, Sean Rourke, Steven P Verney, Kylie Radford, Tedd Judd, Maral Aghvinian, Cara Crook, Denise Oleas, Alex Slaughter, Richard Armenta, Donald Franklin, Thomas Marcotte, Heining Cham, Monica Rivera Mindt
Author Information
Micah J Savin: Department of Psychology, Fordham University. ORCID
Desiree Byrd: Department of Psychology, Queen's College, City University of New York.
Lucette Cysique: Kirby Institute, School of Psychology, University of New South Whales.
Sean Rourke: MAP Centre for Urban Health Solutions, St. Michael's Hospital.
Steven P Verney: Department of Psychology, Transdisciplinary Research, Equity and Engagement Center, University of New Mexico.
Kylie Radford: Neuroscience Research Australia, School of Psychology, University of New South Whales.
Tedd Judd: Department of Psychology, Universidad del Valle de Guatemala.
Maral Aghvinian: Department of Psychology, Fordham University.
Cara Crook: Department of Psychology, Fordham University.
Denise Oleas: Department of Psychology, Fordham University.
Alex Slaughter: Department of Psychology, Fordham University.
Richard Armenta: Department of Kinesiology, Center for Training, Research, and Educational Excellence, California State University, San Marcos.
Donald Franklin: HIV Neurobehavioral Research Program, Department of Psychiatry, UC San Diego Medical Center.
Thomas Marcotte: HIV Neurobehavioral Research Program, Department of Psychiatry, UC San Diego Medical Center.
Heining Cham: Department of Psychology, Fordham University.
Monica Rivera Mindt: Department of Psychology, Fordham University.
OBJECTIVE: This study describes trajectories of cognitive aging among American Indian/Alaskan Native (AI/AN) adults with and without HIV and the role of immunosenescence longitudinally. METHOD: We characterized trajectories of cognitive aging in a sample of 333 AI/AN and 309 non-Hispanic White (NHW) adults who were followed longitudinally for up to 20 years by the HIV Neurobehavioral Research Program (HNRP) across six U.S. research sites. We used growth curve modeling with autoregressive Lag-1 structures and heterogeneous residual variances to assess the role of ethnoracial identity and HIV grouping upon decline in trajectories of cognitive aging. RESULTS: HIV- AI/AN adults demonstrated earlier and steeper decline in normative trajectories of cognitive aging on tasks of processing speed, timed tasks of attention/working memory, executive function, and psychomotor speed in comparison to HIV- NHW adults. Accentuated trajectories of cognitive aging were evident in both HIV+ and HIV+ immunosuppressed groups in comparison to HIV- peers and were primarily driven by the role of immunosenescence. CONCLUSIONS: AI/AN disparities in trajectories of cognitive aging are evident and are likely explained by the interplay of biopsychosociocultural factors, including immunosenescence. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
References
Clin Infect Dis. 2009 Nov 15;49(10):1570-8
[PMID: 19845472]
Neurology. 2010 Dec 7;75(23):2087-96
[PMID: 21135382]
