Plant natural compounds in the cancer treatment: A systematic bibliometric analysis.

Mengting Wang, Yinshuai Li, Tiejun Pan, Nan Jia
Author Information
  1. Mengting Wang: Ningbo Key Laboratory of Agricultural Germplasm Resources Mining and Environmental Regulation, College of Science and Technology, Ningbo University, Cixi, China.
  2. Yinshuai Li: School of Design, Shanghai Jiao Tong University, Shanghai, China.
  3. Tiejun Pan: Ningbo Key Laboratory of Agricultural Germplasm Resources Mining and Environmental Regulation, College of Science and Technology, Ningbo University, Cixi, China.
  4. Nan Jia: Center for Systems Integration and Sustainability, Department of Fisheries and Wildlife, Environmental Science and Policy Program, Michigan State University, East Lansing, MI, USA.

Abstract

Plant-derived natural compounds are significant resources for the discovery of potential anticancer drugs. While research in the plant-based anticancer field has surged in recent years, systematic bibliometric analyses covering a longer period and containing up-to-date publications remain scarce. Here, we conducted a bibliometric analysis of literature on the anticancer properties of plant natural compounds over the past three decades, leveraging the bibliometric framework and open-access platform, KNIME. Our findings showed that the number of plant anticancer-related publications underwent an accelerating growth from 1992 to 2023. The country and institution analyses revealed that countries with traditional medical systems contributed a large portion of publications in the plant anticancer field, such as India, China, and South Korea. This study also highlighted the top ten eminent researchers and publications, assisting researchers in identifying pivotal literature. The primary publications were domains of chemistry and biology-related fields, such as Pharmacology & Pharmacy, Plant Sciences, and Biochemistry & Molecular Biology. Additionally, we noted that flavonoids have been focal plant compounds in anticancer, with strong anticancer potential. Our study provides new insights into the progress and trends in the plant anticancer field and will assist researchers in grasping the future research direction.

Keywords

References

  1. Nutr Cancer. 2019;71(4):676-687 [PMID: 30265812]
  2. J Cell Physiol. 2015 Aug;230(8):1729-39 [PMID: 25204891]
  3. Front Pharmacol. 2020 Aug 07;11:1211 [PMID: 32848800]
  4. J Ethnopharmacol. 2000 Dec;73(3):347-77 [PMID: 11090989]
  5. J Ethnopharmacol. 2005 Aug 22;100(1-2):72-9 [PMID: 16009521]
  6. Nat Commun. 2016 Oct 05;7:12992 [PMID: 27703150]
  7. Med Oncol. 2015 Apr;32(4):101 [PMID: 25737432]
  8. Front Cell Dev Biol. 2021 Aug 10;9:709075 [PMID: 34447752]
  9. Tumour Biol. 2016 Mar;37(3):3451-9 [PMID: 26449828]
  10. Phytother Res. 2005 Jan;19(1):1-22 [PMID: 15799007]
  11. J Evid Based Complementary Altern Med. 2014 Jul;19(3):216-219 [PMID: 24789912]
  12. J BUON. 2016 Sept-Oct;21(5):1050-1060 [PMID: 27837604]
  13. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4601-8 [PMID: 18216259]
  14. ACS Synth Biol. 2023 Jan 20;12(1):27-34 [PMID: 36516122]
  15. J Cancer Res Clin Oncol. 2021 Sep;147(9):2507-2534 [PMID: 34259916]
  16. Front Med (Lausanne). 2021 Oct 26;8:740710 [PMID: 34765618]
  17. Molecules. 2016 Apr 29;21(5): [PMID: 27136524]
  18. Trends Cell Biol. 2013 Dec;23(12):620-33 [PMID: 23958396]
  19. Bioinformatics. 2011 Oct 15;27(20):2907-9 [PMID: 21873641]
  20. J Tradit Complement Med. 2016 Jun 28;7(2):234-244 [PMID: 28417092]
  21. Afr J Tradit Complement Altern Med. 2013 Nov 02;11(1):67-72 [PMID: 24653555]
  22. Saudi Pharm J. 2019 May;27(4):565-573 [PMID: 31061626]
  23. Food Chem Toxicol. 2003 Oct;41(10):1291-8 [PMID: 12909261]
  24. Nat Prod Rep. 2021 Sep 23;38(9):1618-1633 [PMID: 33511969]
  25. Biomed Pharmacother. 2019 Aug;116:109004 [PMID: 31128404]
  26. Biosci Trends. 2019 Jan 22;12(6):526-536 [PMID: 30606977]
  27. Phytother Res. 2021 Mar;35(3):1176-1186 [PMID: 33000538]
  28. Biomedicines. 2021 Apr 27;9(5): [PMID: 33925750]
  29. J Agric Food Chem. 1999 Jan;47(1):36-41 [PMID: 10563845]
  30. Cancer Lett. 2015 Oct 1;366(2):141-9 [PMID: 26185003]
  31. Biochem Pharmacol. 2017 Sep 1;139:82-93 [PMID: 28483461]
  32. Pak J Pharm Sci. 2014 Jul;27(4):793-800 [PMID: 25015442]
  33. Mol Aspects Med. 2018 Jun;61:41-49 [PMID: 29317252]
  34. Phytochemistry. 2000 Nov;55(5):447-56 [PMID: 11140606]
  35. Int J Dermatol. 2010 Sep;49(9):978-86 [PMID: 20883261]
  36. Curr Pharm Des. 2000 Dec;6(18):1811-39 [PMID: 11102564]
  37. J Ethnopharmacol. 2017 Feb 2;197:10-24 [PMID: 27633405]
  38. Int J Food Sci Nutr. 2019 Dec;70(8):941-949 [PMID: 30945577]
  39. Oncogene. 1996 Oct 17;13(8):1605-14 [PMID: 8895505]
  40. J Cancer Epidemiol. 2019 Nov 11;2019:9841295 [PMID: 31827515]
  41. J Med Internet Res. 2021 Aug 10;23(8):e25789 [PMID: 34014832]
  42. J Clin Diagn Res. 2017 Jun;11(6):OD21-OD22 [PMID: 28764232]
  43. Int J Mol Sci. 2022 May 20;23(10): [PMID: 35628532]
  44. Thorac Cancer. 2015 Sep;6(5):561-9 [PMID: 26445604]
  45. Nat Rev Cancer. 2012 Nov;12(11):767-75 [PMID: 23051844]
  46. Biomed Res Int. 2014;2014:906239 [PMID: 24791006]
  47. J Ethnopharmacol. 2010 May 27;129(2):208-13 [PMID: 20307637]
  48. J Clin Oncol. 2020 Feb 10;38(5):423-433 [PMID: 31841354]
  49. Cancer. 2021 Aug 15;127(16):3029-3030 [PMID: 34086348]
  50. Evid Based Complement Alternat Med. 2014;2014:525340 [PMID: 24872833]
  51. Front Pharmacol. 2022 Jan 25;12:824531 [PMID: 35145409]
  52. J Nutr. 2003 Sep;133(9):2812-9 [PMID: 12949370]
  53. Int J Mol Sci. 2020 Dec 22;22(1): [PMID: 33374919]

Word Cloud

Created with Highcharts 10.0.0anticancercompoundspublicationsplantbibliometricnaturalfieldanalysisresearcherspotentialresearchsystematicanalysesliteratureKNIMEstudy&PlantPlant-derivedsignificantresourcesdiscoverydrugsplant-basedsurgedrecentyearscoveringlongerperiodcontainingup-to-dateremainscarceconductedpropertiespastthreedecadesleveragingframeworkopen-accessplatformfindingsshowednumberanticancer-relatedunderwentacceleratinggrowth19922023countryinstitutionrevealedcountriestraditionalmedicalsystemscontributedlargeportionIndiaChinaSouthKoreaalsohighlightedtopteneminentassistingidentifyingpivotalprimarydomainschemistrybiology-relatedfieldsPharmacologyPharmacySciencesBiochemistryMolecularBiologyAdditionallynotedflavonoidsfocalstrongprovidesnewinsightsprogresstrendswillassistgraspingfuturedirectioncancertreatment:AnticancerBibliometricMedicinalplantsNatural

Similar Articles

Cited By

No available data.