OpenLB
Open Library of Bioscience
Advanced Search
Scientific reports
08 07, 2024;14 (1): 18337.

Unravelling the impact of active and passive contributors to arterial stiffness in male mice and their role in vascular aging.

Callan D Wesley, Cedric H G Neutel, Guido R Y De Meyer, Wim Martinet, Pieter-Jan Guns
Author Information
  1. Callan D Wesley: Laboratory of Physiopharmacology, Faculty of Medicine and Health Sciences and Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Campus Drie Eiken, Antwerp, Belgium. callan.wesley@uantwerpen.be. ORCID
  2. Cedric H G Neutel: Laboratory of Physiopharmacology, Faculty of Medicine and Health Sciences and Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Campus Drie Eiken, Antwerp, Belgium. ORCID
  3. Guido R Y De Meyer: Laboratory of Physiopharmacology, Faculty of Medicine and Health Sciences and Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Campus Drie Eiken, Antwerp, Belgium. ORCID
  4. Wim Martinet: Laboratory of Physiopharmacology, Faculty of Medicine and Health Sciences and Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Campus Drie Eiken, Antwerp, Belgium. ORCID
  5. Pieter-Jan Guns: Laboratory of Physiopharmacology, Faculty of Medicine and Health Sciences and Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Campus Drie Eiken, Antwerp, Belgium. ORCID
PMID: 39112507 DOI: 10.1038/s41598-024-68725-9

Abstract

Arterial stiffness, a key indicator of vascular health, encompassing active (vascular tone) and passive (extracellular matrix) components. This study aims to address how these different components affect arterial stiffness along the aorta and the influence of aging. Aortic segments of 12 week and 24 month old (both n���=���6) male C57BL/6J mice were mounted in a Rodent Oscillatory Set-up to study Arterial Compliance, in order to measure arterial stiffness and vascular reactivity. Regional variations in arterial stiffness were evident, with abdominal infrarenal aorta (AIA) exhibiting highest stiffness and smallest diameters. AIA displayed both the highest amount of collagen and collagen:elastin ratio. Regional ex vivo vascular reactivity revealed heightened AIA contractions and lowered NO availability. Aging is a significant factor contributing towards vessel remodelling and arterial stiffness. Aging increased arterial stiffness, aortic diameters, collagen content, and reduced VSMC contraction. The results of this study could identify specific regions or mechanisms to target in the development of innovative therapeutic interventions aimed at enhancing overall vascular health.

References

  1. Am J Hypertens. 2004 Aug;17(8):654-9 [PMID: 15288882]
  2. Cardiovasc Res. 2012 Jul 15;95(2):194-204 [PMID: 22467316]
  3. Adv Cardiol. 2007;44:76-95 [PMID: 17075200]
  4. J Clin Med. 2021 Jan 14;10(2): [PMID: 33466830]
  5. Rev Esp Cardiol. 2005 Feb;58(2):167-74 [PMID: 15743563]
  6. Diabet Med. 2019 Sep;36(9):1125-1132 [PMID: 30920676]
  7. Placenta. 2014 Feb;35 Suppl:S86-92 [PMID: 24411702]
  8. Int J Mol Sci. 2019 Nov 14;20(22): [PMID: 31739395]
  9. Cell Commun Signal. 2022 Nov 21;20(1):180 [PMID: 36411459]
  10. Front Genet. 2015 Mar 30;6:112 [PMID: 25926844]
  11. Ann Thorac Surg. 2013 Dec;96(6):2147-54 [PMID: 24021768]
  12. Eur J Pharmacol. 2012 Dec 5;696(1-3):111-9 [PMID: 23022329]
  13. J Hypertens. 1998 Dec;16(12 Pt 2):2079-84 [PMID: 9886900]
  14. Open Cardiovasc Med J. 2010 Dec 23;4:302-12 [PMID: 21339899]
  15. Circ Res. 2007 Jun 8;100(11):1659-66 [PMID: 17478731]
  16. Exp Mol Med. 2019 Dec 19;51(12):1-15 [PMID: 31857579]
  17. Br J Pharmacol. 2006 Mar;147(5):569-74 [PMID: 16415908]
  18. J Am Coll Cardiol. 2010 Mar 30;55(13):1318-27 [PMID: 20338492]
  19. Acta Pharmacol Sin. 2010 Oct;31(10):1267-76 [PMID: 20802505]
  20. J Physiol. 2016 Nov 1;594(21):6105-6115 [PMID: 27256450]
  21. Cardiovasc Res. 2018 Mar 15;114(4):513-528 [PMID: 29514201]
  22. Hypertension. 2001 Aug;38(2):274-9 [PMID: 11509489]
  23. Commun Biol. 2023 Nov 9;6(1):1137 [PMID: 37945735]
  24. Vascul Pharmacol. 2023 Oct;152:107212 [PMID: 37619798]
  25. Hypertens Res. 2017 Apr;40(4):311-323 [PMID: 27784889]
  26. Br J Pharmacol. 2005 Sep;146(2):288-95 [PMID: 15997227]
  27. J Clin Med. 2023 Mar 16;12(6): [PMID: 36983321]
  28. J R Soc Interface. 2013 Mar 27;10(83):20121004 [PMID: 23536538]
  29. Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H189-H205 [PMID: 29631368]
  30. Commun Biol. 2022 Jun 17;5(1):605 [PMID: 35710942]
  31. J Am Heart Assoc. 2019 Sep 17;8(18):e012670 [PMID: 31512551]
  32. J Anat. 2020 Jan;236(1):142-155 [PMID: 31512228]
  33. Purinergic Signal. 2008 Sep;4(3):267-85 [PMID: 18443747]
  34. Compr Physiol. 2019 Mar 15;9(2):873-904 [PMID: 30873580]
  35. Front Pharmacol. 2020 Jan 21;10:1568 [PMID: 32038245]
  36. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1055-1062 [PMID: 32075419]
  37. Biochim Biophys Acta. 2013 Jul;1832(7):866-75 [PMID: 23220448]
  38. Circulation. 2010 Feb 2;121(4):505-11 [PMID: 20083680]
  39. Antioxid Redox Signal. 2008 Jul;10(7):1185-98 [PMID: 18331202]

Grants

  1. No858070/European Union's Horizon 2020 Research and Innovation Program (H2020-MSCA-ITN program)
  2. BOF/SEP 49 194/Research Council of the University of Antwerp

MeSH Term

Animals
Vascular Stiffness
Male
Aging
Mice
Mice, Inbred C57BL
Collagen
Elastin
Extracellular Matrix
Aorta
Muscle, Smooth, Vascular
Aorta, Abdominal

Chemicals

Collagen
Elastin
Journal Article
Article has an altmetric score of 15

Word Cloud

Created with Highcharts 10.0.0stiffnessvasculararterialAIAhealthactivepassivecomponentsstudyaortaagingmalemicereactivityRegionalhighestdiameterscollagenAgingArterialkeyindicatorencompassingtoneextracellularmatrixaimsaddressdifferentaffectalonginfluenceAorticsegments of12 week24 montholdn���=���6C57BL/6JmountedRodentOscillatorySet-upstudy ArterialComplianceordermeasurevariationsevidentabdominalinfrarenalexhibitingsmallestdisplayedamountcollagen:elastinratioexvivorevealedheightenedcontractionsloweredNOavailabilitysignificantfactorcontributingtowardsvesselremodellingincreasedaorticcontentreducedVSMCcontractionresultsidentifyspecificregionsmechanismstargetdevelopmentinnovativetherapeuticinterventionsaimedenhancingoverallUnravellingimpactcontributorsrole

Similar Articles

Cited By

No available data.