ChatGPT in medicine: A cross-disciplinary systematic review of ChatGPT's (artificial intelligence) role in research, clinical practice, education, and patient interaction.

Afia Fatima, Muhammad Ashir Shafique, Khadija Alam, Tagwa Kalool Fadlalla Ahmed, Muhammad Saqlain Mustafa
Author Information
  1. Afia Fatima: Department of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.
  2. Muhammad Ashir Shafique: Department of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan. ORCID
  3. Khadija Alam: Department of Medicine, Liaquat National Medical College, Karachi, Pakistan.
  4. Tagwa Kalool Fadlalla Ahmed: Department of Medicine, Ahfad University for Women, Omdurman, Sudan. ORCID
  5. Muhammad Saqlain Mustafa: Department of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.

Abstract

BACKGROUND: ChatGPT, a powerful AI language model, has gained increasing prominence in medicine, offering potential applications in healthcare, clinical decision support, patient communication, and medical research. This systematic review aims to comprehensively assess the applications of ChatGPT in healthcare education, research, writing, patient communication, and practice while also delineating potential limitations and areas for improvement.
METHOD: Our comprehensive database search retrieved relevant papers from PubMed, Medline and Scopus. After the screening process, 83 studies met the inclusion criteria. This review includes original studies comprising case reports, analytical studies, and editorials with original findings.
RESULT: ChatGPT is useful for scientific research and academic writing, and assists with grammar, clarity, and coherence. This helps non-English speakers and improves accessibility by breaking down linguistic barriers. However, its limitations include probable inaccuracy and ethical issues, such as bias and plagiarism. ChatGPT streamlines workflows and offers diagnostic and educational potential in healthcare but exhibits biases and lacks emotional sensitivity. It is useful in inpatient communication, but requires up-to-date data and faces concerns about the accuracy of information and hallucinatory responses.
CONCLUSION: Given the potential for ChatGPT to transform healthcare education, research, and practice, it is essential to approach its adoption in these areas with caution due to its inherent limitations.

References

  1. NPJ Digit Med. 2023 Apr 26;6(1):75 [PMID: 37100871]
  2. Aesthet Surg J. 2023 Jul 15;43(8):NP658-NP662 [PMID: 37032521]
  3. Cureus. 2023 Apr 2;15(4):e37023 [PMID: 37143631]
  4. Immunol Lett. 2023 Apr-May;256-257:42-47 [PMID: 37031907]
  5. Ann Biomed Eng. 2023 May;51(5):870-874 [PMID: 37031289]
  6. Clin Chem Lab Med. 2023 Apr 24;61(7):1158-1166 [PMID: 37083166]
  7. Eur J Cardiovasc Nurs. 2023 Oct 19;22(7):e55-e59 [PMID: 36752788]
  8. Cureus. 2023 Mar 13;15(3):e36101 [PMID: 37065364]
  9. Radiology. 2023 Apr;307(2):e230171 [PMID: 36728749]
  10. Cureus. 2023 Feb 4;15(2):e34616 [PMID: 36895547]
  11. Am J Obstet Gynecol. 2023 Aug;229(2):172.e1-172.e12 [PMID: 37088277]
  12. Cureus. 2023 Feb 20;15(2):e35237 [PMID: 36968864]
  13. J Glob Health. 2023 Feb 17;13:01003 [PMID: 36798998]
  14. J Thorac Imaging. 2020 May;35 Suppl 1:S11-S16 [PMID: 32205816]
  15. Cureus. 2023 Aug 3;15(8):e42924 [PMID: 37667724]
  16. Resuscitation. 2023 Apr;185:109729 [PMID: 36773836]
  17. Maxillofac Plast Reconstr Surg. 2023 Mar 8;45(1):13 [PMID: 36882591]
  18. Eur Heart J Open. 2023 Feb 13;3(2):oead007 [PMID: 36915398]
  19. Syst Rev. 2023 Apr 29;12(1):72 [PMID: 37120563]
  20. Lancet Digit Health. 2023 Mar;5(3):e105-e106 [PMID: 36754725]
  21. Headache. 2023 May;63(5):694-696 [PMID: 37171282]
  22. Cureus. 2023 Mar 17;15(3):e36272 [PMID: 37073184]
  23. J Neurosurg. 2023 Mar 24;139(3):904-911 [PMID: 36964734]
  24. Radiology. 2023 Jun;307(5):e230582 [PMID: 37191485]
  25. Nature. 2023 Jan;613(7945):620-621 [PMID: 36653617]
  26. PLOS Digit Health. 2023 Feb 9;2(2):e0000205 [PMID: 36812618]
  27. JAMA Netw Open. 2023 Aug 1;6(8):e2330320 [PMID: 37606922]
  28. Cureus. 2023 Mar 8;15(3):e35894 [PMID: 37033522]
  29. Indian J Radiol Imaging. 2023 Oct 05;33(4):431-435 [PMID: 37811181]
  30. Ann Surg Treat Res. 2023 May;104(5):269-273 [PMID: 37179699]
  31. BJOG. 2024 Jul;131(8):1154-1156 [PMID: 38177090]
  32. J Stomatol Oral Maxillofac Surg. 2023 Oct;124(5):101471 [PMID: 37061037]
  33. J Am Coll Radiol. 2023 Oct;20(10):990-997 [PMID: 37356806]
  34. Cureus. 2023 Apr 11;15(4):e37432 [PMID: 37182055]
  35. Lancet Digit Health. 2023 Mar;5(3):e102 [PMID: 36754723]
  36. Neurosurgery. 2023 Apr 1;92(4):663-664 [PMID: 36757199]
  37. JACC Basic Transl Sci. 2023 Jan 18;8(2):221-223 [PMID: 36908674]
  38. Clin Mol Hepatol. 2023 Jul;29(3):721-732 [PMID: 36946005]
  39. Sci Rep. 2023 Mar 13;13(1):4164 [PMID: 36914821]
  40. Nature. 2023 Feb;614(7947):224-226 [PMID: 36737653]
  41. Cureus. 2023 Apr 28;15(4):e38249 [PMID: 37122982]
  42. Narra J. 2023 Apr;3(1):e103 [PMID: 38450035]
  43. J Educ Eval Health Prof. 2023;20:5 [PMID: 36718045]
  44. J Xray Sci Technol. 2022;30(2):221-230 [PMID: 34924433]
  45. JAMA Intern Med. 2023 Jun 1;183(6):589-596 [PMID: 37115527]
  46. Ann Biomed Eng. 2023 Sep;51(9):1898-1903 [PMID: 37179277]
  47. Cureus. 2023 Mar 23;15(3):e36581 [PMID: 37095800]
  48. Cureus. 2023 Mar 23;15(3):e36590 [PMID: 37095802]
  49. Cureus. 2023 Dec 21;15(12):e50881 [PMID: 38249202]
  50. Diagn Interv Imaging. 2023 Jun;104(6):269-274 [PMID: 36858933]
  51. Int J Environ Res Public Health. 2023 Mar 03;20(5): [PMID: 36901550]
  52. Cureus. 2023 Apr 8;15(4):e37306 [PMID: 37168205]
  53. Science. 2023 Jan 27;379(6630):313 [PMID: 36701446]
  54. Cureus. 2023 Mar 17;15(3):e36302 [PMID: 37073196]
  55. Nature. 2023 Feb;614(7947):214-216 [PMID: 36747115]
  56. Ann Biomed Eng. 2023 Jul;51(7):1371-1373 [PMID: 37071282]
  57. N Biotechnol. 2023 May 25;74:16-24 [PMID: 36754147]
  58. Cureus. 2023 Apr 4;15(4):e37106 [PMID: 37153307]
  59. Cureus. 2023 Mar 12;15(3):e36042 [PMID: 37056551]
  60. Emerg Med Australas. 2023 Oct;35(5):809-811 [PMID: 37142327]
  61. Aesthet Surg J. 2023 Jul 15;43(8):930-937 [PMID: 36943815]
  62. Eur Radiol. 2024 May;34(5):2817-2825 [PMID: 37794249]
  63. Nature. 2023 Jan;613(7945):612 [PMID: 36694020]
  64. Trop Med Health. 2024 Jan 2;52(1):2 [PMID: 38163868]
  65. Cureus. 2023 Mar 16;15(3):e36263 [PMID: 37073200]
  66. Int J Environ Res Public Health. 2023 Feb 15;20(4): [PMID: 36834073]
  67. Crit Care. 2023 Mar 8;27(1):99 [PMID: 36890525]
  68. Cureus. 2023 Mar 3;15(3):e35742 [PMID: 37025739]
  69. Indian J Radiol Imaging. 2023 Aug 21;33(4):440-449 [PMID: 37811189]
  70. Knee Surg Sports Traumatol Arthrosc. 2023 Apr;31(4):1190-1192 [PMID: 36894785]
  71. Gastroenterology. 2023 Aug;165(2):509-511.e7 [PMID: 37150470]
  72. Belitung Nurs J. 2023 Feb 12;9(1):1-5 [PMID: 37469634]
  73. Cureus. 2023 Apr 14;15(4):e37587 [PMID: 37193434]
  74. Aesthet Surg J. 2023 Jun 14;43(7):NP587-NP590 [PMID: 36840479]
  75. Z Gesundh Wiss. 2023 May 26;:1-36 [PMID: 37361298]
  76. Cureus. 2023 Feb 26;15(2):e35484 [PMID: 36999111]
  77. Eur J Clin Pharmacol. 2023 Oct;79(10):1375-1384 [PMID: 37566133]
  78. Cureus. 2023 Feb 15;15(2):e35029 [PMID: 36819954]
  79. Drug Saf. 2023 Aug;46(8):711-713 [PMID: 37306853]
  80. J Chin Med Assoc. 2023 Apr 1;86(4):351-353 [PMID: 36791246]
  81. Cureus. 2023 Mar 19;15(3):e36350 [PMID: 37082496]
  82. Chronic Dis Transl Med. 2021 Mar 03;7(1):35-40 [PMID: 34013178]
  83. Oncoscience. 2022 Dec 21;9:82-84 [PMID: 36589923]
  84. Front Public Health. 2023 Apr 25;11:1166120 [PMID: 37181697]
  85. Microb Biotechnol. 2023 Jun;16(6):1131-1173 [PMID: 36786388]
  86. Semin Ophthalmol. 2023 Jul;38(5):503-507 [PMID: 37133418]
  87. Cureus. 2023 Feb 19;15(2):e35179 [PMID: 36811129]
  88. Lancet Digit Health. 2023 Mar;5(3):e107-e108 [PMID: 36754724]
  89. Arthroscopy. 2023 May;39(5):1121-1122 [PMID: 36797148]
  90. Neurosurg Rev. 2023 Apr 14;46(1):86 [PMID: 37059815]
  91. Med Health Care Philos. 2023 Mar;26(1):1-2 [PMID: 36656495]
  92. Cureus. 2023 Mar 1;15(3):e35649 [PMID: 36875254]
  93. Aesthet Surg J. 2023 Aug 17;43(9):NP715-NP717 [PMID: 37185632]
  94. JNCI Cancer Spectr. 2023 Mar 1;7(2): [PMID: 36808255]
  95. Radiology. 2023 Apr;307(2):e230163 [PMID: 36700838]
  96. Aesthetic Plast Surg. 2023 Oct;47(5):1985-1993 [PMID: 37095384]
  97. Lancet Digit Health. 2023 Apr;5(4):e179-e181 [PMID: 36894409]
  98. JNCI Cancer Spectr. 2023 Mar 1;7(2): [PMID: 36929393]
  99. J Educ Eval Health Prof. 2023;20:1 [PMID: 36627845]
  100. Stem Cell Reports. 2023 Jan 10;18(1):1-2 [PMID: 36630899]
  101. Ann Surg Oncol. 2023 Jul;30(7):3875-3878 [PMID: 37017834]
  102. Ann Biomed Eng. 2023 Jun;51(6):1130-1135 [PMID: 37074486]
  103. Cureus. 2023 Mar 20;15(3):e36390 [PMID: 37090367]
  104. Cureus. 2023 Feb 7;15(2):e34752 [PMID: 36909067]
  105. Ophthalmic Plast Reconstr Surg. 2023 May-Jun 01;39(3):221-225 [PMID: 37166289]
  106. Pediatr Radiol. 2023 May;53(5):813-815 [PMID: 37017719]
  107. Cureus. 2023 Mar 17;15(3):e36290 [PMID: 37073180]
  108. Cureus. 2023 Mar 18;15(3):e36326 [PMID: 37077585]
  109. Ann R Coll Surg Engl. 2004 Sep;86(5):334-8 [PMID: 15333167]
  110. Trends Pharmacol Sci. 2019 Sep;40(9):624-635 [PMID: 31383376]
  111. Epilepsia. 2023 May;64(5):1195-1199 [PMID: 36869421]
  112. JMIR Med Educ. 2023 Apr 21;9:e46599 [PMID: 37083633]
  113. Diabetes Metab Syndr. 2023 Apr;17(4):102744 [PMID: 36989584]
  114. Clin Ther. 2023 Feb;45(2):117-133 [PMID: 36732152]
  115. Eur J Nucl Med Mol Imaging. 2023 May;50(6):1549-1552 [PMID: 36892666]
  116. Cureus. 2023 Mar 24;15(3):e36655 [PMID: 37009366]
  117. Cureus. 2023 Mar 9;15(3):e35946 [PMID: 37038572]
  118. Drug Saf. 2022 May;45(5):439-448 [PMID: 35579809]
  119. JMIR Med Educ. 2023 Feb 8;9:e45312 [PMID: 36753318]
  120. Cureus. 2023 Mar 28;15(3):e36830 [PMID: 37123797]
  121. Ann Biomed Eng. 2023 Aug;51(8):1654-1656 [PMID: 37129780]
  122. Pak J Med Sci. 2023 Mar-Apr;39(2):605-607 [PMID: 36950398]
  123. PLOS Digit Health. 2023 Feb 9;2(2):e0000198 [PMID: 36812645]
  124. Aesthet Surg J. 2023 Nov 16;43(12):NP1085-NP1089 [PMID: 37140001]
  125. Biol Sport. 2023 Apr;40(2):615-622 [PMID: 37077800]
  126. JAMA Netw Open. 2023 Oct 2;6(10):e2336483 [PMID: 37782499]
  127. J Am Med Inform Assoc. 2023 Jun 20;30(7):1237-1245 [PMID: 37087108]
  128. Front Artif Intell. 2023 May 04;6:1169595 [PMID: 37215063]
  129. Eur J Hum Genet. 2024 Apr;32(4):466-468 [PMID: 37246194]
  130. Can Assoc Radiol J. 2024 Feb;75(1):69-73 [PMID: 37078489]
  131. Cureus. 2023 Apr 4;15(4):e37087 [PMID: 37168194]
  132. Skeletal Radiol. 2023 Sep;52(9):1755-1758 [PMID: 37059827]
  133. Resuscitation. 2023 Apr;185:109732 [PMID: 36775020]
  134. Cureus. 2023 Mar 6;15(3):e35850 [PMID: 37033498]
  135. Eur J Hosp Pharm. 2023 Dec 27;31(1):85-86 [PMID: 37339863]
  136. JAMA Ophthalmol. 2023 Jun 1;141(6):589-597 [PMID: 37103928]
  137. Clin Med (Lond). 2023 May;23(3):278-279 [PMID: 37085182]
  138. Nurse Educ. 2023 Sep-Oct 01;48(5):231-233 [PMID: 37130197]
  139. Nurse Educ Pract. 2023 Jan;66:103537 [PMID: 36549229]
  140. Cureus. 2023 Apr 10;15(4):e37401 [PMID: 37181985]

MeSH Term

Humans
Artificial Intelligence
Biomedical Research
Communication

Word Cloud

Created with Highcharts 10.0.0ChatGPTresearchpotentialhealthcarepatientcommunicationrevieweducationpracticelimitationsstudiesapplicationsclinicalsystematicwritingareasoriginalusefulBACKGROUND:powerfulAIlanguagemodelgainedincreasingprominencemedicineofferingdecisionsupportmedicalaimscomprehensivelyassessalsodelineatingimprovementMETHOD:comprehensivedatabasesearchretrievedrelevantpapersPubMedMedlineScopusscreeningprocess83metinclusioncriteriaincludescomprisingcasereportsanalyticaleditorialsfindingsRESULT:scientificacademicassistsgrammarclaritycoherencehelpsnon-EnglishspeakersimprovesaccessibilitybreakinglinguisticbarriersHoweverincludeprobableinaccuracyethicalissuesbiasplagiarismstreamlinesworkflowsoffersdiagnosticeducationalexhibitsbiaseslacksemotionalsensitivityinpatientrequiresup-to-datedatafacesconcernsaccuracyinformationhallucinatoryresponsesCONCLUSION:Giventransformessentialapproachadoptioncautiondueinherentmedicine:cross-disciplinaryChatGPT'sartificialintelligenceroleinteraction

Similar Articles

Cited By