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May, 2023;2 (2): e20220019.

Stimuli-responsive silk fibroin for on-demand drug delivery.

Xiang Lin, Lijun Cai, Xinyue Cao, Yuanjin Zhao
Author Information
  1. Xiang Lin: Department of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering, Southeast University Nanjing China. ORCID
  2. Lijun Cai: Department of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering, Southeast University Nanjing China.
  3. Xinyue Cao: Department of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering, Southeast University Nanjing China.
  4. Yuanjin Zhao: Department of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering, Southeast University Nanjing China.
PMID: 39188280 DOI: 10.1002/SMMD.20220019

Abstract

Stimuli-responsive "smart" hydrogel biomaterials have attracted great attention in the biomedical field, especially in designing novel on-demand drug delivery systems. As a handful natural biomaterial approved by US Food and Drug Administration, silk fibroin (SF) has unique high temperature resistance as well as tunable structural composition. These properties make it one of the most ideal candidates for on-demand drug delivery. Meanwhile, recent advances in polymer modification and nanomaterials have fostered the development of various stimuli-responsive delivery systems. Here, we first review the recent advance in designing responsive SF-based delivery systems in different stimulus sources. These systems are able to release mediators in a desired manner in response to specific stimuli in active or passive manners. We then describe applications of these specially designed responsive delivery systems in wound healing, tumor therapy, as well as immunomodulation. We also discuss the future challenges and prospects of stimuli-responsive SF-based delivery systems.

Keywords

biomedical hydrogel on‐demand drug delivery silk fibroin stimuli‐responsive

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