OpenLB
Open Library of Bioscience
Advanced Search
Veterinary sciences
Aug 05, 2024;11 (8):

Recent Advances in Oral Vaccines for Animals.

Kaining Zhong, Xinting Chen, Junhao Zhang, Xiaoyu Jiang, Junhui Zhang, Minyi Huang, Shuilian Bi, Chunmei Ju, Yongwen Luo
Author Information
  1. Kaining Zhong: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510640, China.
  2. Xinting Chen: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510640, China.
  3. Junhao Zhang: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510640, China.
  4. Xiaoyu Jiang: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510640, China.
  5. Junhui Zhang: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510640, China.
  6. Minyi Huang: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510640, China.
  7. Shuilian Bi: School of Food Science, Guangdong Pharmaceutical University, Zhongshan 528458, China.
  8. Chunmei Ju: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510640, China.
  9. Yongwen Luo: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510640, China. ORCID
PMID: 39195807 DOI: 10.3390/vetsci11080353

Abstract

Compared to traditional injected vaccines, oral vaccines offer significant advantages for the immunization of livestock and wildlife due to their ease of use, high compliance, improved safety, and potential to stimulate mucosal immune responses and induce systemic immunity against pathogens. This review provides an overview of the delivery methods for oral vaccines, and the factors that influence their immunogenicity. We also highlight the global progress and achievements in the development and use of oral vaccines for animals, shedding light on potential future applications in this field.

Keywords

animal health infectious disease mucosal immunity oral vaccines

References

  1. NPJ Vaccines. 2020 Jul 10;5:59 [PMID: 32685200]
  2. Viruses. 2021 Apr 23;13(5): [PMID: 33922562]
  3. J Immunol. 2003 May 15;170(10):5165-75 [PMID: 12734364]
  4. Front Pharmacol. 2021 Apr 30;12:653064 [PMID: 33995068]
  5. Sci Rep. 2017 Mar 09;7:43339 [PMID: 28277549]
  6. Sci Rep. 2018 Aug 17;8(1):12360 [PMID: 30120326]
  7. Front Immunol. 2015 Oct 19;6:519 [PMID: 26539192]
  8. Vaccine. 2013 Oct 25;31(45):5210-5 [PMID: 24021312]
  9. Prev Vet Med. 2023 Dec;221:106080 [PMID: 38029645]
  10. Antiviral Res. 2015 Sep;121:9-15 [PMID: 26093157]
  11. Infect Immun. 2008 Sep;76(9):4137-44 [PMID: 18625740]
  12. Science. 2000 Jun 2;288(5471):1593-4 [PMID: 10858138]
  13. Vaccines (Basel). 2023 Feb 16;11(2): [PMID: 36851331]
  14. Clin Exp Vaccine Res. 2021 Sep;10(3):217-228 [PMID: 34703804]
  15. Oncotarget. 2015 Nov 17;6(36):38504-16 [PMID: 26436700]
  16. Front Physiol. 2022 Jul 18;13:920777 [PMID: 35923229]
  17. Adv Drug Deliv Rev. 2021 Oct;177:113928 [PMID: 34411689]
  18. Viruses. 2023 Jun 20;15(6): [PMID: 37376704]
  19. Porcine Health Manag. 2021 Jan 4;7(1):1 [PMID: 33397477]
  20. Lancet. 2021 Jan 9;397(10269):99-111 [PMID: 33306989]
  21. Vaccines (Basel). 2022 Jul 04;10(7): [PMID: 35891237]
  22. Signal Transduct Target Ther. 2023 Apr 7;8(1):149 [PMID: 37029123]
  23. Lancet Glob Health. 2017 Mar;5(3):e324-e334 [PMID: 28017642]
  24. Vaccine. 2020 Jul 6;38(32):5021-5026 [PMID: 32513512]
  25. J Fish Dis. 2012 Mar;35(3):203-14 [PMID: 22324344]
  26. Cell Tissue Res. 2019 Sep;377(3):289-292 [PMID: 31478136]
  27. Vet Microbiol. 2021 Mar;254:109012 [PMID: 33611126]
  28. Vaccine. 2019 Aug 2;37(33):4743-4749 [PMID: 29054727]
  29. Biotechnol Lett. 2020 Oct;42(10):1907-1917 [PMID: 32385744]
  30. Vaccine. 2009 Nov 5;27(47):6619-26 [PMID: 19698811]
  31. Vaccine. 2020 Oct 27;38(46):7284-7291 [PMID: 33012608]
  32. Res Vet Sci. 2021 May;136:89-96 [PMID: 33592449]
  33. Viruses. 2019 Aug 27;11(9): [PMID: 31461981]
  34. Biosci Rep. 2019 Mar 15;39(3): [PMID: 30808716]
  35. Nat Commun. 2019 Jan 21;10(1):361 [PMID: 30664644]
  36. J Aquat Anim Health. 2015 Jun;27(2):135-43 [PMID: 26030354]
  37. Science. 2021 Nov 26;374(6571):1087-1092 [PMID: 34822299]
  38. Immunol Invest. 1989 Jan-May;18(1-4):583-96 [PMID: 2659521]
  39. Microb Cell Fact. 2020 Mar 2;19(1):53 [PMID: 32122351]
  40. Viral Immunol. 2016 Nov;29(9):526-531 [PMID: 27598459]
  41. Acta Vet Scand. 2021 Oct 13;63(1):40 [PMID: 34645487]
  42. Microb Pathog. 2020 Jan;138:103857 [PMID: 31705999]
  43. Biomaterials. 2010 Oct;31(30):7738-47 [PMID: 20656343]
  44. Virusdisease. 2014 Jan;25(1):1-17 [PMID: 24426306]
  45. Transbound Emerg Dis. 2019 Jul;66(4):1597-1601 [PMID: 30912869]
  46. Viruses. 2022 Apr 25;14(5): [PMID: 35632632]
  47. Fish Shellfish Immunol. 2024 Jun;149:109572 [PMID: 38636739]
  48. BMC Microbiol. 2013 Feb 13;13:35 [PMID: 23402325]
  49. Dev Comp Immunol. 2016 Nov;64:118-37 [PMID: 27018298]
  50. Nature. 1971 Mar 12;230(5289):97-9 [PMID: 4927022]
  51. J Control Release. 2012 Jul 20;161(2):505-22 [PMID: 22353619]
  52. Infect Immun. 2021 Sep 16;89(10):e0008721 [PMID: 34310885]
  53. Vet Res. 2017 Sep 22;48(1):57 [PMID: 28938920]
  54. Sci Rep. 2021 Apr 26;11(1):8977 [PMID: 33903693]
  55. Int J Pharm. 2021 May 15;601:120571 [PMID: 33812967]
  56. Emerg Microbes Infect. 2021 Dec;10(1):913-928 [PMID: 33905300]
  57. Vet Immunol Immunopathol. 2021 Oct;240:110318 [PMID: 34479105]
  58. Fish Shellfish Immunol. 2015 Aug;45(2):955-63 [PMID: 26087276]
  59. Int J Gen Med. 2011 Apr 12;4:299-311 [PMID: 21556316]
  60. J Wildl Dis. 2014 Apr;50(2):374-7 [PMID: 24506428]
  61. Res Vet Sci. 2012 Oct;93(2):675-81 [PMID: 22019192]
  62. Vaccine. 2018 Aug 6;36(32 Pt B):4919-4926 [PMID: 30037482]
  63. BMC Vet Res. 2018 Feb 13;14(1):48 [PMID: 29439696]
  64. Vaccine. 2012 Jan 5;30(2):142-54 [PMID: 22085556]
  65. Sci Rep. 2021 Nov 17;11(1):22377 [PMID: 34789792]
  66. J Wildl Dis. 2016 Oct;52(4):893-901 [PMID: 27505038]
  67. Front Plant Sci. 2021 Oct 04;12:726910 [PMID: 34675949]
  68. J Am Vet Med Assoc. 2012 Jan 15;240(2):163-8 [PMID: 22217024]
  69. Parasit Vectors. 2024 Jun 28;17(1):277 [PMID: 38943202]
  70. Vaccine. 2014 Jun 17;32(29):3675-9 [PMID: 24814554]
  71. Vaccine. 2017 Feb 7;35(6):987-992 [PMID: 28077246]
  72. Clin Exp Vaccine Res. 2015 Jan;4(1):107-13 [PMID: 25648184]
  73. Vet Immunol Immunopathol. 2006 Aug 15;112(3-4):253-63 [PMID: 16701905]
  74. Biotechnol J. 2018 May;13(5):e1700324 [PMID: 29453861]
  75. Vet Microbiol. 2015 May 15;177(1-2):214-8 [PMID: 25759291]
  76. Front Plant Sci. 2021 Nov 18;12:741469 [PMID: 34868126]
  77. Vaccine. 2001 Apr 6;19(20-22):2965-74 [PMID: 11282208]
  78. Virol J. 2011 Jan 09;8:7 [PMID: 21214955]
  79. Adv Drug Deliv Rev. 2021 Dec;179:114021 [PMID: 34710529]
  80. Vet Microbiol. 2017 Sep;208:195-202 [PMID: 28888638]
  81. PLoS One. 2018 Nov 9;13(11):e0206136 [PMID: 30412584]
  82. J Wildl Dis. 2012 Oct;48(4):1010-20 [PMID: 23060502]
  83. Vet Med (Auckl). 2016 Jan 19;7:9-18 [PMID: 30050833]
  84. PLoS One. 2011;6(9):e24905 [PMID: 21935486]
  85. Front Immunol. 2023 Jun 29;14:1192715 [PMID: 37457692]
  86. Lancet. 2020 Aug 15;396(10249):479-488 [PMID: 32702299]
  87. Carbohydr Polym. 2020 Sep 1;243:116434 [PMID: 32532387]
  88. Vet Microbiol. 2011 May 5;149(3-4):295-7 [PMID: 21435804]
  89. J Wildl Dis. 2009 Apr;45(2):363-74 [PMID: 19395746]
  90. Immunobiology. 2019 Mar;224(2):262-269 [PMID: 30579628]
  91. J Appl Microbiol. 2010 Nov;109(5):1632-42 [PMID: 20602654]
  92. Vaccine. 2017 Jul 13;35(32):3938-3944 [PMID: 28641888]
  93. Vaccines (Basel). 2023 Dec 14;11(12): [PMID: 38140252]
  94. Viruses. 2021 Jul 15;13(7): [PMID: 34372588]
  95. J Vet Res. 2022 Nov 15;66(4):473-477 [PMID: 36846029]
  96. Vaccines (Basel). 2021 Nov 30;9(12): [PMID: 34960163]
  97. Vaccines (Basel). 2023 Jul 12;11(7): [PMID: 37515047]
  98. Bioengineered. 2021 Dec;12(1):8325-8335 [PMID: 34592900]
  99. Environ Sci Pollut Res Int. 2013 May;20(5):2893-904 [PMID: 23001758]
  100. Front Vet Sci. 2018 May 18;5:91 [PMID: 29868616]
  101. Acta Vet Scand. 2021 Mar 20;63(1):12 [PMID: 33743780]
  102. J Fish Dis. 2013 Sep;36(9):763-8 [PMID: 23488597]
  103. Pol J Microbiol. 2019;68(2):173-183 [PMID: 31257790]
  104. Vet Microbiol. 2000 Apr 13;73(2-3):93-102 [PMID: 10785320]
  105. Vaccine. 2015 Apr 15;33(16):1959-67 [PMID: 25738814]
  106. Adv Drug Deliv Rev. 2017 May 15;114:116-131 [PMID: 28438674]
  107. Vaccine. 2016 Sep 14;34(40):4792-8 [PMID: 27543453]
  108. Int J Biol Macromol. 2014 Mar;64:6-10 [PMID: 24296407]
  109. BMC Vet Res. 2022 Jan 3;18(1):3 [PMID: 34980121]
  110. Vet Microbiol. 2020 Dec;251:108906 [PMID: 33160196]
  111. Vet Immunol Immunopathol. 2015 Jun 15;165(3-4):127-37 [PMID: 25892368]
  112. Vet Immunol Immunopathol. 2022 Nov;253:110501 [PMID: 36332427]
  113. Adv Drug Deliv Rev. 2015 Aug 30;91:52-69 [PMID: 25817337]
  114. Plant Biotechnol J. 2016 Nov;14(11):2079-2099 [PMID: 27442628]
  115. Vet Microbiol. 2012 Dec 28;161(1-2):20-5 [PMID: 22832373]
  116. Vaccine. 2018 Jul 16;36(30):4433-4439 [PMID: 29909134]
  117. J Clin Invest. 1993 Jan;91(1):123-32 [PMID: 7678599]
  118. Front Immunol. 2024 Jan 12;14:1307621 [PMID: 38283338]
  119. Vaccines (Basel). 2024 Jan 28;12(2): [PMID: 38400118]
  120. Nat Immunol. 2004 Feb;5(2):190-8 [PMID: 14716310]
  121. Appl Environ Microbiol. 2021 Jan 4;87(2): [PMID: 33158889]
  122. J Microbiol. 2019 Jan;57(1):64-73 [PMID: 30552632]
  123. Fish Shellfish Immunol. 2015 Aug;45(2):877-88 [PMID: 26054788]
  124. Infect Immun. 2023 May 16;91(5):e0004323 [PMID: 37036335]
  125. PLoS One. 2015 Jun 17;10(6):e0129276 [PMID: 26083421]
  126. PLoS One. 2017 Jan 25;12(1):e0168851 [PMID: 28121981]
  127. Microbiol Immunol. 1994;38(10):831-6 [PMID: 7532782]
  128. Acta Trop. 2021 Oct;222:106071 [PMID: 34331898]
  129. Vet Microbiol. 2020 Feb;241:108549 [PMID: 31928698]
  130. Zoonoses Public Health. 2009 Aug;56(6-7):262-9 [PMID: 19486317]
  131. Vaccines (Basel). 2022 Aug 27;10(9): [PMID: 36146484]
  132. Vaccine. 2018 Jan 8;36(3):388-394 [PMID: 29223488]
  133. Vaccine. 2019 Aug 2;37(33):4750-4757 [PMID: 29042202]
  134. J Immunol Res. 2016;2016:4131324 [PMID: 28078309]
  135. Front Immunol. 2022 Feb 02;13:809711 [PMID: 35185896]
  136. Expert Rev Vaccines. 2005 Feb;4(1):89-101 [PMID: 15757476]
  137. Viruses. 2018 Apr 06;10(4): [PMID: 29642401]
  138. PLoS One. 2013 May 20;8(5):e63384 [PMID: 23700422]
  139. Vet Microbiol. 2019 Mar;230:49-55 [PMID: 30827404]
  140. Vet Q. 2023 Dec;43(1):1-9 [PMID: 37074390]
  141. J Appl Microbiol. 2018 Feb;124(2):368-378 [PMID: 29178509]
  142. PLoS Negl Trop Dis. 2024 Feb 26;18(2):e0011639 [PMID: 38408125]
  143. Mol Ther. 2016 Aug;24(8):1342-50 [PMID: 27378236]
  144. Antiviral Res. 2010 May;86(2):180-7 [PMID: 20153776]
  145. J Control Release. 2012 Jul 10;161(1):116-23 [PMID: 22549012]
  146. Expert Rev Vaccines. 2023 Jan-Dec;22(1):885-899 [PMID: 37817433]
  147. Fish Shellfish Immunol. 2018 Dec;83:223-231 [PMID: 30217507]
  148. J Drug Target. 2013 Apr;21(3):291-299 [PMID: 30952177]
  149. J Immunol. 2009 May 15;182(10):6061-70 [PMID: 19414757]
  150. Vaccine. 2019 Jul 18;37(31):4310-4317 [PMID: 31248686]
  151. Vaccine. 2016 May 27;34(25):2798-805 [PMID: 27131285]
  152. Immunol Rev. 2008 Oct;225:140-62 [PMID: 18837781]
  153. Pathogens. 2014 Apr 29;3(2):390-403 [PMID: 25437806]
  154. Viruses. 2021 Oct 09;13(10): [PMID: 34696469]
  155. Vaccines (Basel). 2021 Mar 03;9(3): [PMID: 33802556]
  156. J Wildl Dis. 2019 Jan;55(1):200-205 [PMID: 30016214]
  157. Expert Rev Vaccines. 2009 Mar;8(3):347-65 [PMID: 19249976]
  158. Biochim Biophys Acta. 1980 Feb 21;628(1):57-68 [PMID: 6243999]
  159. Front Plant Sci. 2023 Sep 15;14:1251046 [PMID: 37790785]
  160. Vet Microbiol. 2017 Oct;210:83-90 [PMID: 29103702]
  161. Nanomedicine. 2014 Feb;10(2):431-40 [PMID: 24036099]
  162. Front Immunol. 2022 Nov 10;13:1040336 [PMID: 36439092]
  163. Pathogens. 2021 May 18;10(5): [PMID: 34069796]
  164. Arch Virol. 2020 Mar;165(3):609-618 [PMID: 31950289]
  165. Fish Shellfish Immunol. 2020 May;100:18-26 [PMID: 32142871]
  166. Vaccine. 2022 Feb 16;40(8):1065-1073 [PMID: 35086742]
  167. Vaccine. 2014 Feb 12;32(8):984-9 [PMID: 24374501]
  168. Vaccine. 2018 Feb 1;36(6):811-817 [PMID: 29325820]
  169. Mucosal Immunol. 2011 Nov;4(6):603-11 [PMID: 21975936]
  170. BMC Vet Res. 2023 Jan 19;19(1):13 [PMID: 36658534]
  171. Fish Shellfish Immunol. 2013 Dec;35(6):1759-68 [PMID: 23769873]

Grants

  1. 2024A1515010961/Guangdong Basic and Applied Basic Research Foundation
Journal Article Review

Word Cloud

Created with Highcharts 10.0.0vaccinesoralusepotentialmucosalimmunityComparedtraditionalinjectedoffersignificantadvantagesimmunizationlivestockwildlifedueeasehighcomplianceimprovedsafetystimulateimmuneresponsesinducesystemicpathogensreviewprovidesoverviewdeliverymethodsfactorsinfluenceimmunogenicityalsohighlightglobalprogressachievementsdevelopmentanimalssheddinglightfutureapplicationsfieldRecentAdvancesOralVaccinesAnimalsanimalhealthinfectiousdisease

Similar Articles

Cited By