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Antibiotics (Basel, Switzerland)
Aug 14, 2024;13 (8):

Multidrug-Resistant Colonizing Pigs and Farm Workers in Rio de Janeiro State, Brazil: Potential Interspecies Transmission of Livestock-Associated MRSA (LA-MRSA) ST398.

Joana Talim, Ianick Martins, Cassio Messias, Hellen Sabino, Laura Oliveira, Tatiana Pinto, Julia Albuquerque, Aloysio Cerqueira, Ítalo Dolores, Beatriz Moreira, Renato Silveira, Felipe Neves, Renata Rabello
Author Information
  1. Joana Talim: Department of Microbiology and Parasitology, Instituto Biomédico, Universidade Federal Fluminense, Niterói 24020-150, RJ, Brazil. ORCID
  2. Ianick Martins: Faculty of Medicine, Universidade Federal Fluminense, Niterói 24033-900, RJ, Brazil. ORCID
  3. Cassio Messias: Centro de Ciências Biológicas e da Natureza, Universidade Federal do Acre, Rio Branco 69915-900, AC, Brazil. ORCID
  4. Hellen Sabino: Department of Microbiology and Parasitology, Instituto Biomédico, Universidade Federal Fluminense, Niterói 24020-150, RJ, Brazil. ORCID
  5. Laura Oliveira: Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil. ORCID
  6. Tatiana Pinto: Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil. ORCID
  7. Julia Albuquerque: Department of Microbiology and Parasitology, Instituto Biomédico, Universidade Federal Fluminense, Niterói 24020-150, RJ, Brazil. ORCID
  8. Aloysio Cerqueira: Department of Microbiology and Parasitology, Instituto Biomédico, Universidade Federal Fluminense, Niterói 24020-150, RJ, Brazil. ORCID
  9. Ítalo Dolores: Departament of Clinical Medicine, Faculty of Medicine, Universidade de São Paulo, São Paulo 01246-903, SP, Brazil. ORCID
  10. Beatriz Moreira: Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil. ORCID
  11. Renato Silveira: Department of Morphology, Instituto Biomédico, Universidade Federal Fluminense, Niterói 24210-130, RJ, Brazil. ORCID
  12. Felipe Neves: Department of Microbiology and Parasitology, Instituto Biomédico, Universidade Federal Fluminense, Niterói 24020-150, RJ, Brazil. ORCID
  13. Renata Rabello: Department of Microbiology and Parasitology, Instituto Biomédico, Universidade Federal Fluminense, Niterói 24020-150, RJ, Brazil. ORCID
PMID: 39200067 DOI: 10.3390/antibiotics13080767

Abstract

Multidrug-resistant (MDR) has been increasingly isolated from pigs and people in close contact with them, especially livestock-associated methicillin-resistant (LA-MRSA). In this cross-sectional study, we investigated colonization in pigs and farm workers, their resistance profile, and genetic background to estimate interspecies transmission potential within farms from Rio de Janeiro state, Brazil, between 2014 and 2019. We collected nasal swabs from 230 pigs and 27 workers from 16 and 10 farms, respectively. Five MDR strains were subjected to whole genome sequencing. Fourteen (6.1%) pigs and seven (25.9%) humans were colonized with , mostly (64-71%) MDR strains. Resistance to clindamycin, erythromycin, penicillin, and tetracycline was the most common among the pig and human strains investigated. MDR strains shared several resistance genes [, G, , (E), and (M)]. Pig and human strains recovered from the same farm shared the same genetic background and antimicrobial resistance profile. LA-MRSA ST398-SCCV-t011 was isolated from pigs in two farms and from a farm worker in one of them, suggesting interspecies transmission. The association between pig management practices and MDR colonization might be investigated in additional studies.

Keywords

LA-MRSA Staphylococcus aureus farm worker livestock multidrug resistance pig

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Grants

  1. #E-26/211.554/2019-Programa Rede de Pesquisa em Saúde and #E-26/200.855/2021/Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
  2. Finance Code 001/Coordenação de Aperfeicoamento de Pessoal de Nível Superior
  3. Scholarship/National Council for Scientific and Technological Development
Journal Article

Word Cloud

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