Innovations in Early Lung Cancer Detection: Tracing the Evolution and Advancements in Screening.
Lindsey B Cotton, Peter B Bach, Chris Cisar, Caitlin A Schonewolf, Demetria Tennefoss, Anil Vachani, Lisa Carter-Bawa, Ali H Zaidi
Author Information
Lindsey B Cotton: DELFI Diagnostics, Inc., Baltimore, MD 21224, USA. ORCID
Peter B Bach: DELFI Diagnostics, Inc., Baltimore, MD 21224, USA. ORCID
Chris Cisar: DELFI Diagnostics, Inc., Baltimore, MD 21224, USA. ORCID
Caitlin A Schonewolf: DELFI Diagnostics, Inc., Baltimore, MD 21224, USA.
Demetria Tennefoss: DELFI Diagnostics, Inc., Baltimore, MD 21224, USA.
Anil Vachani: Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. ORCID
Lisa Carter-Bawa: Center for Discovery & Innovation at Hackensack Meridian Health, Cancer Prevention Precision Control Institute, Nutley, NJ 07110, USA. ORCID
Ali H Zaidi: Allegheny Health Network Cancer Institute, Pittsburgh, PA 15224, USA. ORCID
Lung cancer mortality rates, particularly non-small cell lung cancer (NSCLC), continue to present a significant global health challenge, and the adoption of lung cancer screening remains limited, often influenced by inequities in access to healthcare. Despite clinical evidence demonstrating the efficacy of annual screening with low-dose computed tomography (LDCT) and recommendations from medical organizations including the U.S. Preventive Services Task Force (USPSTF), the national lung cancer screening uptake remains around 5% among eligible individuals. Advancements in the clinical management of NSCLC have recently become more personalized with the implementation of blood-based biomarker testing. Extensive research into tumor-derived cell-free DNA (cfDNA) through fragmentation offers a novel method for improving early lung cancer detection. This review assesses the screening landscape, explores obstacles to lung cancer screening, and discusses how a plasma whole genome fragmentome test (pWGFrag-Lung) can improve lung cancer screening participation and adherence.
