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Frontiers in endocrinology
2024;15 1422752.

Environmental endocrine disruptor-induced mitochondrial dysfunction: a potential mechanism underlying diabetes and its complications.

Kunhui He, Rumeng Chen, Shuling Xu, Yining Ding, Zhu Wu, Meihua Bao, Binsheng He, Sen Li
Author Information
  1. Kunhui He: The 1st Affiliate Hospital of Changsha Medical University, Changsha Medical University, Changsha, China.
  2. Rumeng Chen: School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
  3. Shuling Xu: School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
  4. Yining Ding: School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
  5. Zhu Wu: The Hunan Provincial Key Laboratory of the TCM Agricultural Biogenomics, Changsha Medical University, Changsha, China.
  6. Meihua Bao: Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, School of Pharmaceutical Science, Changsha Medical University, Changsha, China.
  7. Binsheng He: The Hunan Provincial Key Laboratory of the TCM Agricultural Biogenomics, Changsha Medical University, Changsha, China.
  8. Sen Li: School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
PMID: 39211449 DOI: 10.3389/fendo.2024.1422752

Abstract

Diabetes and its complications significantly affect individuals' quality of life. The etiology of diabetes mellitus and its associated complications is complex and not yet fully understood. There is an increasing emphasis on investigating the effects of endocrine disruptors on diabetes, as these substances can impact cellular processes, energy production, and utilization, ultimately leading to disturbances in energy homeostasis. Mitochondria play a crucial role in cellular energy generation, and any impairment in these organelles can increase susceptibility to diabetes. This review examines the most recent epidemiological and pathogenic evidence concerning the link between endocrine disruptors and diabetes, including its complications. The analysis suggests that endocrine disruptor-induced mitochondrial dysfunction-characterized by disruptions in the mitochondrial electron transport chain, dysregulation of calcium ions (Ca), overproduction of reactive oxygen species (ROS), and initiation of signaling pathways related to mitochondrial apoptosis-may be key mechanisms connecting endocrine disruptors to the development of diabetes and its complications.

Keywords

diabetic complications endocrine disruptor mitochondrial dysfunction reactive oxygen species type 2 diabetes mellitus

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MeSH Term

Humans
Endocrine Disruptors
Mitochondria
Diabetes Mellitus
Animals
Diabetes Complications
Reactive Oxygen Species
Environmental Exposure

Chemicals

Endocrine Disruptors
Reactive Oxygen Species
Journal Article Review
Article has an altmetric score of 2

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