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International journal of dermatology
Dec, 2024;63 (12): e383-e389.

Characteristics of late-onset Beh��et's disease and comparison with juvenile and adult-onset Beh��et's disease.

K��bra Nursel B��l��k, Afet Akda�� K��se
Author Information
  1. K��bra Nursel B��l��k: Department of Dermatology and Venereology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. ORCID
  2. Afet Akda�� K��se: Department of Dermatology and Venereology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
PMID: 39215427 DOI: 10.1111/ijd.17456

Abstract

BACKGROUND: The course of late-onset Beh��et's disease (LBD) is unknown. This study aimed to determine the characteristics and systemic involvement of LBD.
METHODS: In this retrospective, cross-sectional, and comparative study, 700 patient files from 4100 patients diagnosed with Beh��et's disease (BD) were selected and divided into three groups: LBD, adult BD (ABD), and juvenile BD (JBD). The age limits for LBD and JBD were determined to be 42 and 16, respectively. LBD patients were compared to ABD and JBD patients in terms of demographics, systemic involvement, and disease duration.
RESULTS: The LBD rate among BD patients was 4.7% (183/4,100). The time from initial symptom occurrence to the age at which the BD criteria were met was longer in LBD than in ABD or JBD. Except for genital ulcers, the frequencies of involvement in LBD were similar to those in ABD and JBD. The frequency of family history was significantly lower in LBD (12%) than in ABD (15.9%) or JBD (18.2%). The time from the initial symptom to oral aphthae, genital ulcers, and eye involvement was longer in LBD than in ABD or JBD. Furthermore, erythema nodosum was observed after a longer duration in LBD than in ABD.
CONCLUSION: Considering that involvement occurs much later in LBD and there are no differences in the frequencies of involvement except for genital ulcers, LBD patients should be followed up as closely as ABD and JBD patients.

Keywords

Beh��et's disease adult���onset Beh��et's disease juvenile Beh��et's disease late���onset Beh��et's disease

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MeSH Term

Humans
Behcet Syndrome
Male
Adult
Female
Retrospective Studies
Age of Onset
Cross-Sectional Studies
Young Adult
Adolescent
Middle Aged
Stomatitis, Aphthous
Erythema Nodosum
Time Factors
Oral Ulcer
Eye Diseases
Journal Article Comparative Study

Word Cloud

Created with Highcharts 10.0.0LBDdiseaseBeh��et'sABDJBDinvolvementpatientsBDjuvenilelongergenitalulcerslate-onsetstudysystemicagedurationtimeinitialsymptomfrequenciesBACKGROUND:courseunknownaimeddeterminecharacteristicsMETHODS:retrospectivecross-sectionalcomparative700patientfiles4100diagnosedselecteddividedthreegroups:adultlimitsdetermined4216respectivelycomparedtermsdemographicsRESULTS:rateamong47%183/4100occurrencecriteriametExceptsimilarfrequencyfamilyhistorysignificantlylower12%159%182%oralaphthaeeyeFurthermoreerythemanodosumobservedCONCLUSION:ConsideringoccursmuchlaterdifferencesexceptfollowedcloselyCharacteristicscomparisonadult-onsetadult���onsetlate���onset

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