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Schizophrenia (Heidelberg, Germany)
Sep 02, 2024;10 (1): 75.

Gut microbiome and schizophrenia: insights from two-sample Mendelian randomization.

Keer Zhou, Ancha Baranova, Hongbao Cao, Jing Sun, Fuquan Zhang
Author Information
  1. Keer Zhou: Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
  2. Ancha Baranova: School of Systems Biology, George Mason University, Manassas, VA, USA.
  3. Hongbao Cao: School of Systems Biology, George Mason University, Manassas, VA, USA.
  4. Jing Sun: Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China. jingsun2007@163.com.
  5. Fuquan Zhang: Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China. zfqeee@126.com. ORCID
PMID: 39223235 DOI: 10.1038/s41537-024-00497-7

Abstract

Growing evidence suggests a potential link between the gut microbiome and schizophrenia. However, it is unclear whether the gut microbiome is causally associated with schizophrenia. We performed two-sample bidirectional Mendelian randomization to detect bidirectional causal relationships between gut microbiome and schizophrenia. Summary genome-wide association study (GWAS) datasets of the gut microbiome from the MiBioGen consortium (n = 18,340) and schizophrenia (n = 130,644) were utilized in our study. Then a cohort of sensitive analyses was followed to validate the robustness of MR results. We identified nine taxa that exerted positive causal effects on schizophrenia (OR: 1.08-1.16) and six taxa that conferred negative causal effects on schizophrenia (OR: 0.88-0.94). On the other hand, the reverse MR analysis showed that schizophrenia may increase the abundance of nine taxa (OR: 1.03-1.08) and reduce the abundance of two taxa (OR: 0.94). Our study unveiled mutual causal relationships between gut microbiome and schizophrenia. The findings may provide evidence for the treatment potential of gut microbiomes in schizophrenia.

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Journal Article
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