SIADH and mixed delirium following the abrupt cessation of long-acting benzodiazepines: a case report.

Ahmad F Alenezi, Ahmed Alnuaimi, Dan Liberman
Author Information
  1. Ahmad F Alenezi: Department of Medicine, McGill University, 3605 Rue de la Montagne, Montreal, QC H3G 2M1, Canada. ORCID
  2. Ahmed Alnuaimi: Department of Medicine, McGill University, 3605 Rue de la Montagne, Montreal, QC H3G 2M1, Canada.
  3. Dan Liberman: Division of Geriatric Medicine, Jewish General Hospital, McGill University, 3755 Chem. de la Côte-Sainte-Catherine, Montreal, QC H3T 1E2, Canada.

Abstract

Benzodiazepines (BZDs) are among the most commonly used medications due to their efficacy and rapid onset of action. Although they offer significant therapeutic benefits in treating various psychiatric and neurological conditions, their clinical utility is limited by substantial risks, including dependency and withdrawal symptoms. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) has been linked to BZD withdrawal. In this case report, we examine the case of an elderly female presented with a mixed delirium and SIADH following the abrupt cessation of long-term clonazepam therapy. To our knowledge, this is the second case that documents a link between SIADH and BZD withdrawal.

Keywords

References

  1. Neuropharmacology. 2009 Jan;56(1):141-8 [PMID: 18760291]
  2. BMJ. 1988 Oct 1;297(6652):858 [PMID: 3140958]
  3. JAMA Psychiatry. 2015 Feb;72(2):136-42 [PMID: 25517224]
  4. Consult Pharm. 2008 Apr;23(4):324-34 [PMID: 18454589]
  5. Am Fam Physician. 2017 Nov 1;96(9):606-610 [PMID: 29094883]
  6. Neurol Int. 2022 Aug 22;14(3):648-663 [PMID: 35997362]
  7. J Am Soc Nephrol. 2017 May;28(5):1340-1349 [PMID: 28174217]

Word Cloud

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