OpenLB
Open Library of Bioscience
Advanced Search
Drug delivery
Dec, 2024;31 (1): 2400476.

Recent advances of injectable in situ-forming hydrogels for preventing postoperative tumor recurrence.

Zhanpeng Wang, Bingtao Zhai, Jing Sun, Xiaofei Zhang, Junbo Zou, Yajun Shi, Dongyan Guo
Author Information
  1. Zhanpeng Wang: School of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, People's Republic of China.
  2. Bingtao Zhai: School of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, People's Republic of China.
  3. Jing Sun: School of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, People's Republic of China.
  4. Xiaofei Zhang: School of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, People's Republic of China.
  5. Junbo Zou: School of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, People's Republic of China.
  6. Yajun Shi: School of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, People's Republic of China.
  7. Dongyan Guo: School of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, People's Republic of China.
PMID: 39252545 DOI: 10.1080/10717544.2024.2400476

Abstract

The unavoidable residual tumor tissue from surgery and the strong aggressiveness of tumor cells pose challenges to the postoperative treatment of tumor patients, accompanied by in situ tumor recurrence and decreased quality of life. Therefore, there is an urgent need to explore appropriate postoperative therapeutic strategies to remove residual tumor cells after surgery to inhibit tumor recurrence and metastasis after surgery. In recent years, with the rapid development of biomedical materials, the study of local delivery systems as postoperative delivery of therapeutic agents has gradually attracted the attention of researchers. Injectable in situ-forming hydrogel is a locally administered agent injected in situ as a solution that can be loaded with various therapeutic agents and rapidly gels to form a semi-solid gel at the treatment site. This type of hydrogel tightly fills the surgical site and covers irregular excision surfaces. In this paper, we review the recent advances in the application of injectable in situ-forming hydrogels in postoperative therapy, focusing on the matrix materials of this type of hydrogel and its application in the postoperative treatment of different types of tumors, as well as discussing the challenges and prospects of its clinical application.

Keywords

Hydrogel local drug delivery postoperative tumor treatment

References

  1. Carbohydr Polym. 2022 Dec 15;298:120123 [PMID: 36241295]
  2. Int J Pharm. 2019 Mar 10;558:268-283 [PMID: 30611748]
  3. Carbohydr Polym. 2022 Feb 15;278:118943 [PMID: 34973761]
  4. Carbohydr Polym. 2024 Oct 1;341:122348 [PMID: 38876718]
  5. J Nanobiotechnology. 2021 Jul 3;19(1):198 [PMID: 34217325]
  6. Int J Pharm. 2020 Mar 30;578:119100 [PMID: 32014600]
  7. Future Oncol. 2020 May;16(15):975-989 [PMID: 32352320]
  8. Theranostics. 2020 Feb 10;10(7):3049-3063 [PMID: 32194854]
  9. Adv Sci (Weinh). 2022 Aug;9(24):e2200681 [PMID: 35751467]
  10. Eur J Pharm Sci. 2021 Dec 1;167:105992 [PMID: 34517104]
  11. J Tissue Eng Regen Med. 2018 Dec;12(12):2234-2247 [PMID: 30334613]
  12. Chin Clin Oncol. 2022 Jun;11(3):19 [PMID: 35695055]
  13. Front Neurol. 2022 Jun 23;13:884158 [PMID: 35812101]
  14. Macromol Rapid Commun. 2020 Apr;41(7):e1900650 [PMID: 32078206]
  15. Biosci Trends. 2021 Jul 6;15(3):138-141 [PMID: 33746184]
  16. Adv Exp Med Biol. 2020;1268:123-139 [PMID: 32918216]
  17. J Control Release. 2020 Mar 10;319:311-321 [PMID: 31911154]
  18. Carbohydr Polym. 2014 Jan 30;101:171-8 [PMID: 24299762]
  19. Int J Biol Macromol. 2019 May 1;128:957-964 [PMID: 30685304]
  20. Biomaterials. 2019 Mar;195:100-110 [PMID: 30623788]
  21. Carbohydr Polym. 2019 Oct 15;222:115039 [PMID: 31320053]
  22. J Mater Chem B. 2024 May 22;12(20):4909-4921 [PMID: 38682601]
  23. J Control Release. 2023 Apr;356:205-218 [PMID: 36870543]
  24. Front Surg. 2021 Aug 09;8:666400 [PMID: 34434955]
  25. Cureus. 2020 Jul 15;12(7):e9211 [PMID: 32821563]
  26. Bioeng Transl Med. 2020 Apr 03;5(2):e10158 [PMID: 32440563]
  27. Int J Bioprint. 2021 Jun 29;7(3):389 [PMID: 34286155]
  28. ACS Omega. 2019 Feb 28;4(2):4040-4048 [PMID: 30842986]
  29. Front Med. 2021 Apr;15(2):155-169 [PMID: 33754281]
  30. Gels. 2022 Aug 19;8(8): [PMID: 36005122]
  31. Mater Sci Eng C Mater Biol Appl. 2021 Oct;129:112390 [PMID: 34579909]
  32. Pharmaceutics. 2019 Dec 10;11(12): [PMID: 31835628]
  33. Biomed Pharmacother. 2024 Aug;177:117118 [PMID: 39002440]
  34. Int J Biol Macromol. 2024 May;266(Pt 1):131179 [PMID: 38552698]
  35. Biomater Sci. 2021 Feb 23;9(4):1466 [PMID: 33570070]
  36. Cancer Biother Radiopharm. 2020 Feb;35(1):1-9 [PMID: 31621382]
  37. Carbohydr Polym. 2019 Dec 1;225:115207 [PMID: 31521293]
  38. Ann Biomed Eng. 2020 Jan;48(1):9-25 [PMID: 31576501]
  39. Onco Targets Ther. 2021 Nov 12;14:5249-5260 [PMID: 34803385]
  40. Bioact Mater. 2024 May 14;39:14-24 [PMID: 38783926]
  41. Br J Radiol. 2023 Dec;96(1152):20230717 [PMID: 37750832]
  42. Biomed Pharmacother. 2022 Jun;150:113017 [PMID: 35483193]
  43. Polymers (Basel). 2022 Aug 18;14(16): [PMID: 36015626]
  44. Asian J Pharm Sci. 2021 May;16(3):280-306 [PMID: 34276819]
  45. Int J Biol Macromol. 2024 Mar;260(Pt 2):129553 [PMID: 38246439]
  46. Int J Biol Macromol. 2018 Apr 15;110:17-29 [PMID: 29169942]
  47. Biomater Sci. 2019 Feb 26;7(3):860-866 [PMID: 30698593]
  48. Adv Drug Deliv Rev. 2024 Jul;210:115331 [PMID: 38729264]
  49. Front Immunol. 2021 Jun 21;12:697362 [PMID: 34234785]
  50. BMJ. 2021 Jul 14;374:n1560 [PMID: 34261630]
  51. Adv Sci (Weinh). 2024 Jan;11(3):e2304053 [PMID: 38029340]
  52. Colloids Surf B Biointerfaces. 2021 Apr;200:111591 [PMID: 33548893]
  53. Colloids Surf B Biointerfaces. 2022 Oct;218:112747 [PMID: 35961115]
  54. Nano Lett. 2022 Mar 23;22(6):2251-2260 [PMID: 35254836]
  55. ACS Appl Mater Interfaces. 2019 Jun 19;11(24):21381-21390 [PMID: 31141335]
  56. Biomater Sci. 2024 Feb 27;12(5):1151-1170 [PMID: 38319379]
  57. J Clin Oncol. 2019 Dec 1;37(34):3212-3222 [PMID: 31150315]
  58. J Mater Chem B. 2024 Jul 17;12(28):6968-6980 [PMID: 38915270]
  59. J Nanobiotechnology. 2022 Aug 11;20(1):366 [PMID: 35953821]
  60. Int J Pharm. 2020 Mar 15;577:119048 [PMID: 31978462]
  61. Int J Biol Macromol. 2023 Feb 15;228:111-122 [PMID: 36563819]
  62. Biomaterials. 2023 Aug;299:122162 [PMID: 37257401]
  63. J Mater Chem B. 2024 Mar 20;12(12):2938-2949 [PMID: 38426380]
  64. ACS Appl Mater Interfaces. 2023 Jan 18;15(2):2639-2655 [PMID: 36603840]
  65. Bioact Mater. 2022 Nov 08;23:1-15 [PMID: 36406247]
  66. Sci Adv. 2020 Jan 17;6(3):eaay0065 [PMID: 32010768]
  67. N Engl J Med. 2021 Nov 25;385(22):2066-2076 [PMID: 34818481]
  68. J Nanobiotechnology. 2024 Jun 21;22(1):355 [PMID: 38902678]
  69. Theranostics. 2019 Apr 13;9(9):2572-2594 [PMID: 31131054]
  70. J Nanobiotechnology. 2023 Feb 10;21(1):50 [PMID: 36765361]
  71. Oncogene. 2021 Feb;40(8):1503-1515 [PMID: 33452455]
  72. Biomaterials. 2021 Dec;279:121182 [PMID: 34688987]
  73. Adv Drug Deliv Rev. 2021 Oct;177:113957 [PMID: 34481032]
  74. J Tissue Eng Regen Med. 2020 Nov;14(11):1549-1569 [PMID: 32841503]
  75. Adv Exp Med Biol. 2020;1250:35-48 [PMID: 32601936]
  76. Adv Healthc Mater. 2017 Nov;6(21): [PMID: 28758712]
  77. Mar Drugs. 2023 Feb 24;21(3): [PMID: 36976196]
  78. Pharmaceutics. 2019 Aug 12;11(8): [PMID: 31408954]
  79. Semin Cancer Biol. 2022 Nov;86(Pt 3):408-419 [PMID: 35066156]
  80. Biomater Sci. 2022 Mar 2;10(5):1257-1266 [PMID: 35080214]
  81. Biotechnol Bioeng. 2009 Mar 1;102(4):1259-67 [PMID: 18949749]
  82. BMC Cancer. 2010 May 18;10:211 [PMID: 20482808]
  83. Adv Sci (Weinh). 2024 Mar;11(9):e2305508 [PMID: 38145957]
  84. Oncology. 2018;95(3):147-155 [PMID: 29847835]
  85. Biomaterials. 2021 Aug;275:120992 [PMID: 34218050]
  86. Nat Rev Gastroenterol Hepatol. 2019 Oct;16(10):589-604 [PMID: 31439937]
  87. Mol Cancer. 2023 Jan 12;22(1):10 [PMID: 36635761]
  88. Adv Drug Deliv Rev. 2022 Jun;185:114308 [PMID: 35472398]
  89. J Mater Chem B. 2022 Oct 5;10(38):7717-7731 [PMID: 35920389]
  90. J Biomed Mater Res B Appl Biomater. 2020 Apr;108(3):619-628 [PMID: 31087625]
  91. Asian J Pharm Sci. 2024 Apr;19(2):100901 [PMID: 38645467]
  92. Pharmaceutics. 2022 Mar 16;14(3): [PMID: 35336026]
  93. Biomater Adv. 2023 Feb;145:213224 [PMID: 36516618]
  94. Adv Sci (Weinh). 2021 Nov;8(21):e2101796 [PMID: 34519180]
  95. Exp Biol Med (Maywood). 2021 Aug;246(16):1791-1801 [PMID: 33820469]
  96. CA Cancer J Clin. 2024 May-Jun;74(3):224-226 [PMID: 38572764]
  97. Polymers (Basel). 2022 Dec 07;14(24): [PMID: 36559720]
  98. J Am Chem Soc. 2021 Jun 2;143(21):8116-8128 [PMID: 33928777]
  99. J Control Release. 2016 Dec 10;243:29-42 [PMID: 27693428]
  100. Sci Adv. 2021 Oct 08;7(41):eabg5841 [PMID: 34613775]
  101. Langmuir. 2020 Nov 10;36(44):13263-13273 [PMID: 33124835]
  102. ACS Appl Mater Interfaces. 2024 Feb 28;16(8):9656-9668 [PMID: 38377529]
  103. Acta Biomater. 2023 Mar 1;158:228-238 [PMID: 36563777]
  104. Shock. 2021 Apr 1;55(4):455-464 [PMID: 32881756]
  105. No Shinkei Geka. 2021 May;49(3):588-596 [PMID: 34092564]
  106. Int J Nanomedicine. 2024 Jun 11;19:5605-5618 [PMID: 38882547]
  107. J Nanobiotechnology. 2021 Oct 7;19(1):307 [PMID: 34620160]
  108. Mater Today Bio. 2022 Sep 05;16:100416 [PMID: 36105677]
  109. J Control Release. 2022 Sep;349:565-579 [PMID: 35835399]
  110. Carbohydr Polym. 2023 Feb 15;302:120349 [PMID: 36604043]
  111. World J Surg Oncol. 2022 Mar 4;20(1):69 [PMID: 35246145]
  112. Medicina (Kaunas). 2022 Feb 20;58(2): [PMID: 35208642]
  113. Biotechnol Adv. 2017 Sep;35(5):530-544 [PMID: 28558979]
  114. Chin Med J (Engl). 2022 Feb 9;135(5):584-590 [PMID: 35143424]
  115. Nat Nanotechnol. 2021 May;16(5):538-548 [PMID: 33526838]
  116. J Nanobiotechnology. 2022 May 28;20(1):245 [PMID: 35643505]
  117. J Pineal Res. 2018 Oct;65(3):e12507 [PMID: 29766567]
  118. Biomacromolecules. 2019 Sep 9;20(9):3375-3384 [PMID: 31389691]
  119. J Control Release. 2024 Jul;371:406-428 [PMID: 38849093]
  120. ACS Appl Polym Mater. 2023 Feb 21;5(3):2154-2165 [PMID: 36935654]
  121. J Minim Access Surg. 2019 Jul-Sep;15(3):214-218 [PMID: 29794359]
  122. Adv Drug Deliv Rev. 2018 Mar 1;127:167-184 [PMID: 29567395]
  123. Nano Lett. 2021 Apr 14;21(7):2926-2931 [PMID: 33769824]
  124. Molecules. 2020 Jun 06;25(11): [PMID: 32517278]
  125. Adv Sci (Weinh). 2024 Jul;11(26):e2402208 [PMID: 38704692]
  126. Polymers (Basel). 2020 Mar 05;12(3): [PMID: 32150904]
  127. Gels. 2022 Jul 20;8(7): [PMID: 35877539]
  128. ACS Appl Mater Interfaces. 2024 Apr 10;16(14):17267-17284 [PMID: 38556996]
  129. Carbohydr Polym. 2022 Feb 15;278:118994 [PMID: 34973798]
  130. Acta Biomater. 2022 Jan 15;138:168-181 [PMID: 34755605]
  131. Adv Mater. 2024 May;36(21):e2313188 [PMID: 38362813]
  132. Cir Cir. 2021;89(5):574-582 [PMID: 34665164]
  133. J Tissue Eng. 2023 Aug 14;14:20417314231190288 [PMID: 37588339]
  134. Eur J Pharm Biopharm. 2020 Dec;157:154-164 [PMID: 33222768]
  135. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2024 Jan-Feb;16(1):e1937 [PMID: 38072393]
  136. J Control Release. 2019 Mar 10;297:60-70 [PMID: 30684513]
  137. Ann Surg Oncol. 2022 Oct;29(11):6497-6500 [PMID: 35838905]
  138. Neurooncol Adv. 2022 Jan 12;4(1):vdab189 [PMID: 35118382]
  139. Int J Clin Oncol. 2022 Aug;27(8):1238-1246 [PMID: 35226235]
  140. Polymers (Basel). 2021 Mar 30;13(7): [PMID: 33808492]
  141. Neurol Med Chir (Tokyo). 2021 Sep 15;61(9):536-548 [PMID: 34092748]
  142. Acta Biomater. 2019 Sep 15;96:281-294 [PMID: 31319202]
  143. ACS Biomater Sci Eng. 2024 Mar 11;10(3):1207-1234 [PMID: 38416058]
  144. Biomedicines. 2021 Mar 22;9(3): [PMID: 33810154]
  145. Int J Biol Macromol. 2021 Nov 1;190:693-699 [PMID: 34520776]
  146. Int J Biol Macromol. 2020 Nov 1;162:1414-1428 [PMID: 32777428]
  147. Lancet. 2022 Oct 15;400(10360):1345-1362 [PMID: 36084663]
  148. Adv Radiat Oncol. 2021 Nov 21;7(2):100858 [PMID: 35387424]
  149. Biomaterials. 2019 Oct;219:119182 [PMID: 31415954]
  150. Pharmaceutics. 2021 Aug 28;13(9): [PMID: 34575432]
  151. Cells. 2022 Dec 28;12(1): [PMID: 36611908]
  152. Cancer. 2021 Aug 15;127(16):3029-3030 [PMID: 34086348]
  153. Biomater Sci. 2018 Feb 27;6(3):661-671 [PMID: 29423489]
  154. Gels. 2020 May 08;6(2): [PMID: 32397180]
  155. Small. 2021 Sep;17(38):e2101356 [PMID: 34382336]
  156. Nat Biomed Eng. 2020 Nov;4(11):1090-1101 [PMID: 32778697]
  157. Crit Rev Eukaryot Gene Expr. 2020;30(4):291-297 [PMID: 32894659]
  158. Mater Sci Eng C Mater Biol Appl. 2020 Sep;114:111046 [PMID: 32993992]
  159. ACS Biomater Sci Eng. 2022 Jun 13;8(6):2518-2525 [PMID: 35522951]
  160. Mar Drugs. 2021 May 10;19(5): [PMID: 34068547]
  161. ACS Nano. 2022 Apr 26;16(4):6064-6079 [PMID: 35344338]
  162. ACS Macro Lett. 2020 Apr 21;9(4):512-524 [PMID: 35648497]
  163. Adv Sci (Weinh). 2022 Apr;9(10):e2104165 [PMID: 35142093]
  164. Carbohydr Polym. 2019 Jan 1;203:302-309 [PMID: 30318217]
  165. Curr Pharm Des. 2022;28(11):910-921 [PMID: 34879797]
  166. Macromol Rapid Commun. 2022 Sep;43(18):e2200203 [PMID: 35477942]
  167. Acta Biomater. 2022 Nov;153:204-215 [PMID: 36108967]
  168. Biomaterials. 2022 May;284:121506 [PMID: 35390709]
  169. Polymers (Basel). 2018 Jan 31;10(2): [PMID: 30966173]
  170. J Mater Chem B. 2018 May 14;6(18):2821-2830 [PMID: 32254235]
  171. Nanoscale. 2019 Nov 28;11(46):22182-22195 [PMID: 31728467]
  172. Carbohydr Polym. 2021 Aug 15;266:118100 [PMID: 34044919]
  173. Carbohydr Polym. 2022 Dec 15;298:120081 [PMID: 36241273]
  174. Adv Healthc Mater. 2021 Jan;10(1):e2001239 [PMID: 32935937]
  175. Adv Mater. 2016 May;28(19):3669-76 [PMID: 26991248]

MeSH Term

Humans
Hydrogels
Neoplasm Recurrence, Local
Animals
Injections
Drug Delivery Systems
Antineoplastic Agents
Neoplasms

Chemicals

Hydrogels
Antineoplastic Agents
Journal Article Review

Word Cloud

Created with Highcharts 10.0.0tumorpostoperativetreatmentsurgeryrecurrencetherapeuticdeliverysitu-forminghydrogelapplicationresidualcellschallengessiturecentmaterialslocalagentssitetypeadvancesinjectablehydrogelsunavoidabletissuestrongaggressivenessposepatientsaccompanieddecreasedqualitylifeThereforeurgentneedexploreappropriatestrategiesremoveinhibitmetastasisyearsrapiddevelopmentbiomedicalstudysystemsgraduallyattractedattentionresearchersInjectablelocallyadministeredagentinjectedsolutioncanloadedvariousrapidlygelsformsemi-solidgeltightlyfillssurgicalcoversirregularexcisionsurfacespaperreviewtherapyfocusingmatrixdifferenttypestumorswelldiscussingprospectsclinicalRecentpreventingHydrogeldrug

Similar Articles

Cited By