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American journal of physiology. Renal physiology
Nov 01, 2024;327 (5): F726-F738.

Role of local angiotensin II signaling in bladder function.

Hannah A Anderson, Gabriella L Robilotto, Aaron D Mickle
Author Information
  1. Hannah A Anderson: Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
  2. Gabriella L Robilotto: Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States. ORCID
  3. Aaron D Mickle: Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, Wisconsin, United States. ORCID
PMID: 39265080 DOI: 10.1152/ajprenal.00204.2024

Abstract

Angiotensin II signaling plays a crucial role in many different diseases. Although it has been known for several decades that local angiotensin II signaling molecules are present in the bladder, the understanding of their functions there is still limited, especially compared with other organ systems such as cardiovascular and respiratory systems. This article reviews current literature regarding local angiotensin II signaling in the urinary bladder. By reviewing several decades of literature, the field has provided strong evidence to support the presence of local angiotensin II signaling in the bladder, including the expression of angiotensin type 1 receptor and angiotensin type 2 receptor in both human and animal tissues. In addition, evidence suggests a functional role of angiotensin type 1 receptor in mediating bladder contractions. In bladder disease models, angiotensin II signaling can be upregulated, and angiotensin type 1 receptor activity is associated with increases in inflammation, fibrosis, and oxidative stress. We also address the gaps in knowledge that remain in understanding local angiotensin II signaling in the bladder, including limitations on clinical translatability. Although there is a strong foundation regarding the local presence and role of angiotensin II signaling in the bladder, further research is needed to support translational applications.

Keywords

angiotensin bladder physiology receptor signaling

References

  1. Int Urol Nephrol. 2015 Aug;47(8):1297-302 [PMID: 26049975]
  2. J Biol Chem. 2001 May 25;276(21):18551-6 [PMID: 11279033]
  3. BMC Urol. 2024 Jan 28;24(1):21 [PMID: 38281923]
  4. Hypertension. 2013 Jan;61(1):253-8 [PMID: 23150519]
  5. Exp Ther Med. 2022 Mar;23(3):216 [PMID: 35126719]
  6. PLoS One. 2016 Dec 21;11(12):e0168772 [PMID: 28002455]
  7. Eur Urol. 2009 Feb;55(2):482-9 [PMID: 18378069]
  8. Neurourol Urodyn. 2007;26(1):81-8; discussion 89 [PMID: 17029249]
  9. Kidney Int Suppl (2011). 2014 Nov;4(1):58-64 [PMID: 26312151]
  10. Curr Hypertens Rep. 2018 Mar 19;20(3):19 [PMID: 29556787]
  11. Nat Rev Drug Discov. 2011 Jun 24;10(7):536-55 [PMID: 21701502]
  12. Expert Opin Pharmacother. 2018 Aug;19(12):1369-1373 [PMID: 30074829]
  13. Rev Urol. 2005;7 Suppl 6:S3-S13 [PMID: 16986027]
  14. Inflammation. 2017 Dec;40(6):2033-2041 [PMID: 28799018]
  15. Can J Physiol Pharmacol. 1984 Apr;62(4):390-5 [PMID: 6329496]
  16. J Urol. 1990 Aug;144(2 Pt 1):390-2 [PMID: 2165184]
  17. J Urol. 2017 Feb;197(2):423-431 [PMID: 27565397]
  18. Int J Prev Med. 2021 Jan 19;12:4 [PMID: 34084301]
  19. J Urol. 1993 Sep;150(3):1056-9 [PMID: 8345584]
  20. Kidney Int. 2000 Nov;58(5):2018-27 [PMID: 11044222]
  21. Am J Respir Crit Care Med. 2012 Oct 15;186(8):780-9 [PMID: 22859525]
  22. Neurourol Urodyn. 2021 Jan;40(1):137-146 [PMID: 33606304]
  23. Neurourol Urodyn. 2014 Mar;33(3):350-7 [PMID: 23775684]
  24. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13607-12 [PMID: 15342908]
  25. Endocr J. 2007 Apr;54(2):211-9 [PMID: 17237611]
  26. Pediatr Res. 2009 Aug;66(2):121-7 [PMID: 19390491]
  27. J Urol. 1999 Nov;162(5):1779-84 [PMID: 10524934]
  28. BJU Int. 2012 Jun;109(11):1676-84 [PMID: 21951754]
  29. Neurourol Urodyn. 2014 Nov;33(8):1178-81 [PMID: 24038343]
  30. Endocr Rev. 2003 Jun;24(3):261-71 [PMID: 12788798]
  31. Urology. 2012 Jul;80(1):225.e13-8 [PMID: 22521193]
  32. Am J Physiol Renal Physiol. 2020 Aug 1;319(2):F345-F357 [PMID: 32715763]
  33. Organogenesis. 2013 Jul-Sep;9(3):224-33 [PMID: 23917648]
  34. Am J Hypertens. 2000 Jan;13(1 Pt 2):31S-38S [PMID: 10678286]
  35. Diagnostics (Basel). 2021 Dec 29;12(1): [PMID: 35054241]
  36. J Pain Palliat Care Pharmacother. 2018 Mar;32(1):49-58 [PMID: 30212267]
  37. Am J Physiol Renal Physiol. 2023 Aug 1;325(2):F150-F163 [PMID: 37318991]
  38. Physiol Rev. 2004 Jul;84(3):935-86 [PMID: 15269341]
  39. Front Physiol. 2023 Sep 04;14:1232017 [PMID: 37731545]
  40. Curr Biol. 2014 May 19;24(10):R453-62 [PMID: 24845678]
  41. Trends Pharmacol Sci. 2008 Jul;29(7):367-74 [PMID: 18579222]
  42. Biomed Res Int. 2017;2017:4269875 [PMID: 29124064]
  43. Muscle Nerve. 2012 Jan;45(1):2-8 [PMID: 22190298]
  44. Hypertens Res. 2024 Apr;47(4):987-997 [PMID: 38351189]
  45. Int J Urol. 2012 May;19(5):457-64 [PMID: 22320898]
  46. Am J Hypertens. 2000 Jan;13(1 Pt 2):18S-24S [PMID: 10678284]
  47. Br J Urol. 1997 Apr;79(4):516-24 [PMID: 9126078]
  48. Neurourol Urodyn. 2021 Jan;40(1):102-111 [PMID: 33074588]
  49. Braz J Med Biol Res. 2004 Aug;37(8):1263-73 [PMID: 15273829]
  50. BJU Int. 2012 Jun;109(12):1841-6 [PMID: 21939491]
  51. Sci Rep. 2016 Jun 08;6:27552 [PMID: 27271344]
  52. Front Pharmacol. 2022 Jan 28;12:743682 [PMID: 35153736]
  53. Arthritis Res Ther. 2012 Oct 18;14(5):R223 [PMID: 23079082]
  54. Pharmacol Ther. 2006 Dec;112(3):668-76 [PMID: 16837049]
  55. Sci Rep. 2016 Feb 17;6:19670 [PMID: 26883396]
  56. Am J Physiol Renal Physiol. 2021 May 1;320(5):F814-F825 [PMID: 33719572]
  57. EMBO Mol Med. 2010 Jul;2(7):247-57 [PMID: 20597104]
  58. Am J Surg Pathol. 1987 Sep;11(9):668-73 [PMID: 3631381]
  59. Curr Probl Cardiol. 2023 Jan;48(1):101414 [PMID: 36155200]
  60. Gut. 2020 May;69(5):841-851 [PMID: 31409604]
  61. Curr Bladder Dysfunct Rep. 2020 Mar;15(1):9-14 [PMID: 33456639]
  62. Regul Pept. 2010 Jun 8;162(1-3):79-83 [PMID: 20153783]
  63. Adv Exp Med Biol. 1999;462:183-91 [PMID: 10599423]
  64. Low Urin Tract Symptoms. 2013 May;5(2):90-5 [PMID: 26663376]
  65. Am J Physiol Renal Physiol. 2022 Oct 1;323(4):F411-F424 [PMID: 35979968]
  66. Pharmacol Res. 2008 Sep-Oct;58(3-4):196-201 [PMID: 18639638]
  67. Sci Rep. 2024 Jul 12;14(1):16134 [PMID: 38997336]
  68. Cell Death Differ. 2015 Nov;22(11):1764-74 [PMID: 26434982]
  69. Hypertension. 2015 Nov;66(5):920-6 [PMID: 26324508]
  70. Br J Pharmacol. 1997 Jul;121(6):1081-6 [PMID: 9249242]
  71. Hypertens Res. 2008 Feb;31(2):175-84 [PMID: 18360035]
  72. J Urol. 1998 Nov;160(5):1812-9 [PMID: 9783965]
  73. Adv Clin Exp Med. 2017 Oct;26(7):1047-1051 [PMID: 29211350]
  74. Int Urol Nephrol. 2023 Dec;55(12):3065-3075 [PMID: 37594700]
  75. Urol Int. 2012;89(2):241-5 [PMID: 22777104]
  76. Inflammation. 2017 Jun;40(3):861-870 [PMID: 28233078]
  77. Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1315-20 [PMID: 18202178]
  78. Low Urin Tract Symptoms. 2012 Mar;4 Suppl 1:81-6 [PMID: 26676705]
  79. PLoS One. 2013 May 15;8(5):e63760 [PMID: 23691091]
  80. Neurourol Urodyn. 2013 Jan;32(1):70-4 [PMID: 22693136]
  81. Int Neurourol J. 2018 Jun;22(2):77-82 [PMID: 29991228]
  82. Urology. 2004 Mar;63(3 Suppl 1):11-6 [PMID: 15013647]
  83. Pediatr Nephrol. 2004 Aug;19(8):853-7 [PMID: 15179569]
  84. Am J Physiol Renal Physiol. 2019 Jul 1;317(1):F90-F98 [PMID: 31091120]
  85. Life Sci. 2021 Aug 15;279:119690 [PMID: 34111460]
  86. Urology. 2007 Apr;69(4 Suppl):34-40 [PMID: 17462477]
  87. J Urol. 2012 Jul;188(1):183-9 [PMID: 22591967]
  88. Histopathology. 2010 Sep;57(3):371-83 [PMID: 20840668]
  89. J Urol. 2001 May;165(5):1735-8 [PMID: 11342966]
  90. Diagnostics (Basel). 2022 Dec 21;13(1): [PMID: 36611307]
  91. Am J Physiol Cell Physiol. 2023 Mar 1;324(3):C787-C797 [PMID: 36689673]
  92. Int J Mol Sci. 2020 Dec 30;22(1): [PMID: 33396702]
  93. Eur Urol. 2012 Jan;61(1):29-53 [PMID: 21920661]
  94. Histopathology. 2017 Sep;71(3):415-424 [PMID: 28394416]
  95. Eur J Pharmacol. 1984 Apr 6;99(4):287-93 [PMID: 6145601]
  96. Hypertension. 2010 Apr;55(4):924-31 [PMID: 20157051]
  97. Urology. 2012 Nov;80(5):1163.e1-7 [PMID: 22795377]
  98. Am J Physiol Renal Physiol. 2020 Jun 1;318(6):F1400-F1408 [PMID: 32308022]
  99. J Neurosci. 2018 Aug 8;38(32):7032-7057 [PMID: 29976627]
  100. Am J Respir Crit Care Med. 2000 Nov;162(5):1783-8 [PMID: 11069813]
  101. Eur J Pharmacol. 2022 May 5;922:174911 [PMID: 35337813]
  102. Am J Physiol. 1994 Jun;266(6 Pt 2):R1861-7 [PMID: 8024040]
  103. J Am Soc Nephrol. 2019 Nov;30(11):2159-2176 [PMID: 31462402]
  104. Mol Immunol. 2010 Jul;47(11-12):1943-55 [PMID: 20537709]
  105. Circ Res. 1998 Dec 14-28;83(12):1182-91 [PMID: 9851935]
  106. Curr Protein Pept Sci. 2004 Aug;5(4):267-73 [PMID: 15320733]
  107. Acta Physiol Scand. 1992 Jul;145(3):253-9 [PMID: 1519483]
  108. J Exp Clin Cancer Res. 2017 Jun 9;36(1):77 [PMID: 28599664]
  109. Am J Physiol. 1996 Nov;271(5 Pt 2):R1186-92 [PMID: 8945952]
  110. J Neurosci. 2017 Mar 29;37(13):3478-3490 [PMID: 28219987]
  111. Am J Physiol Renal Physiol. 2020 Mar 1;318(3):F683-F688 [PMID: 31904285]
  112. Neurourol Urodyn. 2014 Jan;33(1):9-16 [PMID: 23847015]
  113. Am J Kidney Dis. 1996 Oct;28(4):603-9 [PMID: 8840953]
  114. Neurourol Urodyn. 2015 Jan;34(1):72-8 [PMID: 25646557]
  115. Aging (Albany NY). 2020 Jan 22;12(2):1545-1562 [PMID: 31968309]
  116. Physiol Rep. 2014 Mar 27;2(3):e00260 [PMID: 24760514]
  117. Regul Pept. 2000 Jul 28;91(1-3):21-7 [PMID: 10967199]
  118. Nat Rev Urol. 2018 Dec;15(12):750-776 [PMID: 30361493]
  119. Hypertens Res. 2009 Jul;32(7):533-6 [PMID: 19461648]
  120. BJU Int. 2007 Sep;100(3):664-7 [PMID: 17550411]
  121. Arch Physiol Biochem. 2021 Feb;127(1):1-5 [PMID: 30739509]
  122. Urology. 2001 Jun;57(6 Suppl 1):47-55 [PMID: 11378050]
  123. Am J Hypertens. 2013 Oct;26(10):1224-33 [PMID: 23761490]
  124. Front Physiol. 2022 Jul 19;13:920636 [PMID: 35928558]
  125. Life Sci. 1998;63(19):PL289-95 [PMID: 9806232]
  126. Nat Commun. 2023 Aug 4;14(1):4690 [PMID: 37542033]
  127. Front Physiol. 2022 Mar 31;13:841181 [PMID: 35431993]
  128. J Gerontol A Biol Sci Med Sci. 2012 Dec;67(12):1373-8 [PMID: 22972942]
  129. Nat Rev Nephrol. 2020 May;16(5):269-288 [PMID: 32060481]
  130. Life Sci. 2015 Aug 15;135:77-86 [PMID: 26006040]
  131. J Biol Chem. 2008 Jun 6;283(23):15611-8 [PMID: 18408003]
  132. Am J Hypertens. 2022 Jan 5;35(1):22-30 [PMID: 33899909]
  133. Pain. 2014 Jul;155(7):1280-1287 [PMID: 24704367]
  134. Gen Hosp Psychiatry. 2011 Mar-Apr;33(2):143-9 [PMID: 21596207]
  135. Am J Physiol. 1998 Nov;275(5):C1247-54 [PMID: 9814973]
  136. Clin Cancer Res. 2001 Apr;7(4):1073-8 [PMID: 11309359]
  137. Life Sci. 2013 Nov 19;93(22):820-9 [PMID: 24050930]
  138. Eur Respir J. 2018 Jun 21;51(6): [PMID: 29929959]
  139. J Urol. 2002 Apr;167(4):1763-7 [PMID: 11912405]
  140. Expert Opin Emerg Drugs. 2015;20(4):555-70 [PMID: 26535808]
  141. Nature. 2017 Apr 20;544(7650):327-332 [PMID: 28379944]
  142. Arterioscler Thromb Vasc Biol. 2002 Aug 1;22(8):1257-66 [PMID: 12171785]
  143. Kidney Int. 1999 Nov;56(5):1654-61 [PMID: 10571773]
  144. Hypertension. 2008 Aug;52(2):256-63 [PMID: 18541733]
  145. Mol Cancer Ther. 2010 Nov;9(11):2982-92 [PMID: 20978160]
  146. Molecules. 2015 Mar 02;20(3):3868-97 [PMID: 25738535]
  147. Am J Physiol Renal Physiol. 2021 Apr 1;320(4):F644-F653 [PMID: 33615887]
  148. Nephrology (Carlton). 2005 Aug;10(4):377-81 [PMID: 16109085]
  149. Sci Rep. 2023 Oct 23;13(1):18062 [PMID: 37872186]
  150. Front Endocrinol (Lausanne). 2013 Oct 18;4:150 [PMID: 24151488]
  151. Pediatr Nephrol. 2008 Jul;23(7):1037-51 [PMID: 18481112]
  152. Curr Urol. 2012 Sep;6(2):62-6 [PMID: 24917715]
  153. Eur Urol. 2019 Jun;75(6):988-1000 [PMID: 30922690]
  154. Tissue Cell. 2022 Oct;78:101877 [PMID: 35930992]
  155. J Med Chem. 2020 Mar 12;63(5):1978-1995 [PMID: 32030982]
  156. Neurourol Urodyn. 2016 Nov;35(8):908-913 [PMID: 26250880]
  157. Neurourol Urodyn. 2018 Mar;37(3):926-941 [PMID: 28990698]
  158. Biomedicines. 2022 Sep 23;10(10): [PMID: 36289642]
  159. Hypertension. 2021 Jun;77(6):1845-1856 [PMID: 33840201]
  160. Expert Opin Pharmacother. 2019 Aug;20(12):1417-1419 [PMID: 31070933]
  161. Naunyn Schmiedebergs Arch Pharmacol. 2018 Aug;391(8):883-889 [PMID: 29868927]
  162. J Pharmacol Sci. 2023 Oct;153(2):69-72 [PMID: 37640471]

Grants

  1. R01 DK132003/NIDDK NIH HHS
  2. none/Rita Allen Foundation (RAF)
  3. DK132003/HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

MeSH Term

Humans
Angiotensin II
Urinary Bladder
Animals
Signal Transduction
Receptor, Angiotensin, Type 1
Receptor, Angiotensin, Type 2
Muscle Contraction
Urinary Bladder Diseases

Chemicals

Angiotensin II
Receptor, Angiotensin, Type 1
Receptor, Angiotensin, Type 2
Journal Article Review

Word Cloud

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