This review suggests that shamans were in charge of the healing process in pre-dynastic Egypt. After the unification of Lower and Upper Egypt by Narmer in 3100 BC, shamans evolved into the Sem priests, who were responsible for the king's health. With the change in Egyptian religion in the fourth dynasty (2613-2494 BC), Ra, the sun god, was revered as the supreme power, replacing the king. The emergence of mass festivities to celebrate Ra led to the priests of Sekhmet in the fifth dynasty (2494-2345 BC) checking the sanitation of bull meat that was provided to the populace in an attempt to avoid infectious epidemics. This seems to be the first recognition that disease might be transmitted from animals to humans. They used medical folklore, incantations, spells, and charms available at the House of Life, previously used by the lector priest. By 2487 BC, the first medical curative procedure was performed by Ni-Ankh-Sekhmet who cured the bleeding of a king's nose.
